Hydroderm Plus (Chlorhexidine Gluconate)

Hydroderm Plus is indicated for several external antiseptic applications where reduction of microbial load is required.

• Skin antisepsis before minor procedures such as catheter insertion or venipuncture.
• Cleaning of superficial wounds, abrasions, or burns to prevent infection.
• Pre‑operative skin preparation for surgical sites in accordance with standard protocols.
• Disinfection of intact skin prior to the application of medical devices or dressings.
• Use as a rinse for hand hygiene in clinical or home settings when a stronger antiseptic is desired.

• Chlorhexidine gluconate exerts its antiseptic effect by binding to negatively charged bacterial cell walls and disrupting membrane integrity. The cationic molecules insert into phospholipid bilayers, causing increased permeability, leakage of intracellular constituents, and ultimately cell lysis. This broad‑spectrum activity affects Gram‑positive and Gram‑negative bacteria, some fungi, and enveloped viruses, providing rapid reduction of microbial populations on the skin. The action is concentration‑dependent and persists for several hours after application.

Topical application of Hydroderm Plus may be associated with local skin reactions; while most users experience only mild or transient effects, occasional more pronounced responses have been reported.

Common

• Mild erythema or redness at the application site.
• Transient itching or tingling sensation.
• Slight stinging or burning during initial contact.
• Dryness or peeling of the treated skin.
• Localized swelling that resolves within hours.
• Temporary discoloration that fades without treatment.
• Mild scaling of the skin surface.

Serious

• Severe allergic dermatitis with swelling, blistering, or intense itching.
• Contact urticaria presenting as hives beyond the treated area.
• Chemical burns or necrosis with prolonged exposure.
• Systemic hypersensitivity reactions, though rare.
• Persistent ulceration at the site of application.
• Delayed hypersensitivity reaction appearing days after use.
• Anaphylactic symptoms such as difficulty breathing.

When using Hydroderm Plus, several precautions should be observed to minimize the risk of irritation, allergic response, or reduced effectiveness.

• Avoid application on mucous membranes, eyes, or broken skin unless directed by a healthcare professional.
• Do not use on patients with known hypersensitivity to chlorhexidine or related compounds.
• Limit the duration of continuous exposure; rinse off after the recommended contact time for surgical preparation.
• Keep the product away from open wounds that are deep or heavily contaminated without medical supervision.
• Store at room temperature, protected from light and moisture, and keep the container tightly closed.
• Discontinue use and seek medical advice if any sign of severe irritation or allergic reaction develops.

Hydroderm Plus may interact with other topical agents or systemic medications that affect skin integrity or immune response.

Avoid

• Avoid simultaneous use with other chlorhexidine‑containing products to prevent cumulative irritation.
• Do not apply over topical antibiotics or antiseptics that contain alcohol, as this can increase skin dryness and burning.
• Avoid use on extensive body surface areas in infants or young children without professional guidance.

Use with caution

• Use with caution when combined with skin‑sensitizing agents such as retinoids or benzoyl peroxide; monitor for increased irritation.
• Caution is advised in patients receiving systemic antihistamines or immunosuppressants, as altered skin reactions may occur.
• When used before surgical procedures, ensure that residual product is adequately removed if incompatible with the planned antiseptic protocol.