Product image of Hydrokortison Tiofarma (Hydrocortisone) supplied by GNH India

Hydrokortison Tiofarma

Active Ingredient:
Hydrocortisone
Origin:
EU

Hydrokortison Tiofarma (Hydrocortisone)

Hydrocortisone, the active ingredient in Hydrokortison Tiofarma, is a corticosteroid presented as an oral tablet for oral use. It replaces deficient cortisol in adrenal insufficiency and reduces inflammation in a range of disorders such as allergic reactions and autoimmune conditions. It is indicated for patients with primary or secondary adrenal failure, for control of acute inflammatory episodes, and for management of severe allergic responses.

GNH India supplies Hydrokortison Tiofarma as a licensed, GDP‑compliant international pharmaceutical supplier, providing reliable bulk shipments to hospitals, pharmacies and clinics worldwide, with adherence to EU quality standards.

Manufacturer / TM Owner

Tiofarma B.V.

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Indications & Clinical Uses

Hydrocortisone is a glucocorticoid that modulates inflammatory and immune pathways, providing therapeutic benefit in several endocrine and inflammatory conditions.

  • Adrenal insufficiency: Restores cortisol levels, helping maintain blood pressure, metabolism and stress response.
  • Inflammatory disorders: Reduces tissue inflammation and swelling, improving symptoms in conditions such as arthritis or dermatitis.
  • Allergic reactions: Suppresses immune over‑reaction, alleviating severe allergy symptoms like hives, edema or airway inflammation.

How It Works

  • Hydrocortisone penetrates cell membranes and binds to intracellular glucocorticoid receptors. The drug‑receptor complex translocates to the nucleus, where it interacts with glucocorticoid response elements on DNA, altering transcription of multiple genes. This results in decreased production of pro‑inflammatory cytokines, inhibition of leukocyte migration, and suppression of immune cell activation, collectively producing anti‑inflammatory and immunosuppressive effects.

Side Effects

Hydrocortisone may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Increased appetite: May lead to weight gain.
  • Fluid retention: Can cause mild edema.
  • Mood changes: Irritability or mild anxiety.
  • Gastrointestinal discomfort: Nausea or abdominal pain.
  • Skin thinning: Easy bruising or stretch marks.

Serious or Rare Side Effects

  • Severe infection: Suppressed immunity may predispose to opportunistic infections.
  • Hyperglycemia: Elevated blood sugar, especially in diabetic patients.
  • Adrenal suppression: Reduced endogenous cortisol production after abrupt discontinuation.
  • Osteoporosis: Decreased bone mineral density with long‑term use.
  • Psychiatric disturbances: Psychosis or severe mood swings.

Precautions & Warnings

Before prescribing hydrocortisone, clinicians should evaluate several safety considerations.

  • Assess adrenal function: Confirm diagnosis of insufficiency before initiating therapy.
  • Monitor blood glucose: Check glucose levels in diabetic or at‑risk patients.
  • Evaluate infection risk: Use caution in patients with active infections.
  • Review concomitant medications: Identify drugs that may enhance corticosteroid effects.
  • Consider bone health: Implement calcium and vitamin D supplementation for long‑term use.
  • Store at ambient temperature: Keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Hydrocortisone can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole): May increase systemic corticosteroid exposure.
  • Anticoagulants (warfarin): Enhanced anticoagulant effect, requiring monitoring.
  • Live vaccines: Immunosuppression can reduce vaccine efficacy and increase infection risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: May exacerbate electrolyte imbalances.
  • Antidiabetic agents: May require dose adjustments due to hyperglycemia.
  • NSAIDs: Combined use can increase risk of gastrointestinal ulceration.
  • Antihistamines: May mask signs of adrenal crisis.

Frequently Asked Questions

Hydrokortison Tiofarma contains hydrocortisone, a glucocorticoid used to replace deficient cortisol in adrenal insufficiency, to reduce inflammation in disorders such as arthritis or dermatitis, and to control severe allergic reactions by suppressing excessive immune activity.

Hydrocortisone binds to intracellular glucocorticoid receptors, forming a complex that moves into the cell nucleus. There it interacts with specific DNA sequences, modifying gene transcription to lower production of inflammatory cytokines, inhibit leukocyte migration, and dampen immune cell activation, resulting in anti‑inflammatory and immunosuppressive effects.

The appropriate dose of Hydrokortison Tiofarma is individualized by the prescribing clinician based on the patient’s condition, severity, age, weight, and response to therapy. Dosage regimens are not standardized and should follow the prescriber’s instructions.

Safety data for hydrocortisone in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should discuss individual circumstances and consider alternative therapies when appropriate.

To place an enquiry, visit the product page on gnhindia.com, enter the required quantity, and submit the request. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydrocortisone has a relatively short half‑life and mimics natural cortisol, making it suitable for replacement therapy and short‑term anti‑inflammatory use. Other glucocorticoids such as prednisolone or dexamethasone are more potent and have longer durations, which may be preferred for chronic conditions requiring fewer daily doses.

Hydrokortison Tiofarma should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

The medication is taken orally, usually with water. The exact timing (e.g., with meals or on an empty stomach) and frequency are determined by the prescribing clinician based on the therapeutic indication and patient-specific factors.

Serious risks include severe infections due to immune suppression, hyperglycemia especially in diabetic patients, adrenal suppression after abrupt discontinuation, osteoporosis with long‑term use, and rare psychiatric disturbances such as psychosis. Patients should be monitored regularly for these complications.

Hydrokortison Tiofarma is contraindicated in patients with known hypersensitivity to hydrocortisone or any excipients, in those with systemic fungal infections, and in individuals where corticosteroid therapy is deemed unsafe by their physician. Caution is also advised for patients with uncontrolled infections, uncontrolled diabetes, or severe osteoporosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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