Product image of Hydrokortison Tiofarma (Hydrocortisone) supplied by GNH India

Hydrokortison Tiofarma

Active Ingredient:
Hydrocortisone
Origin:
EU

Hydrokortison Tiofarma (Hydrocortisone)

Hydrocortisone, the active ingredient in Hydrokortison Tiofarma, is a corticosteroid (glucocorticoid) presented as an oral dosage form for systemic use. It is employed to replace deficient cortisol in adrenal insufficiency and to modulate immune‑mediated inflammation in various disorders.
GNH India supplies Hydrokortison Tiofarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tiofarma B.V.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Hydrocortisone acts on the hypothalamic‑pituitary‑adrenal axis and immune pathways, providing hormone replacement and anti‑inflammatory effects.

  • Adrenal insufficiency: restores physiologic cortisol levels and prevents adrenal crisis.
  • Congenital adrenal hyperplasia: supplies glucocorticoid needed to suppress excess androgen production.
  • Inflammatory and autoimmune disorders: reduces inflammation and immune activity in conditions such as rheumatoid arthritis or ulcerative colitis.

How It Works

  • Hydrocortisone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and interacts with glucocorticoid response elements. This modulates gene transcription, up‑regulating anti‑inflammatory proteins (e.g., annexin‑1) and down‑regulating pro‑inflammatory cytokines (e.g., IL‑1, TNF‑α), thereby decreasing inflammation and providing glucocorticoid hormone replacement.

Side Effects

Hydrocortisone may cause a range of adverse reactions, from mild to severe, depending on dose and duration of therapy.

Common Side Effects

  • Increased appetite or weight gain
  • Fluid retention and mild edema
  • Elevated blood glucose levels
  • Mood changes such as irritability or euphoria
  • Gastrointestinal discomfort or dyspepsia
  • Minor skin thinning or bruising

Serious or Rare Side Effects

  • Severe infection due to immunosuppression
  • Osteoporosis or pathological fractures
  • Adrenal suppression on abrupt discontinuation
  • Hypertension or cardiovascular events
  • Psychiatric disturbances including psychosis
  • Allergic reactions such as rash or anaphylaxis

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for potential complications.

  • Assess adrenal function: confirm diagnosis of insufficiency before replacement.
  • Screen for infections: avoid use in uncontrolled systemic infections.
  • Monitor glucose: patients with diabetes may require dose adjustments.
  • Evaluate bone health: long‑term use can reduce bone mineral density.
  • Review concomitant medications: potential for drug interactions.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Hydrocortisone can influence the pharmacokinetics or pharmacodynamics of several agents, requiring clinical vigilance.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase systemic exposure.
  • Anticoagulants (e.g., warfarin): enhanced anticoagulant effect, risk of bleeding.
  • Live vaccines: immunosuppression may reduce vaccine efficacy and increase infection risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): additive risk of gastrointestinal ulceration.
  • Diuretics: may potentiate hypokalemia.
  • Antidiabetic agents: glucocorticoid‑induced hyperglycemia may require dose adjustments.

Frequently Asked Questions

Hydrokortison Tiofarma contains hydrocortisone, a glucocorticoid used to replace deficient cortisol in primary or secondary adrenal insufficiency, to manage congenital adrenal hyperplasia, and to treat inflammatory or autoimmune disorders such as rheumatoid arthritis or ulcerative colitis by reducing inflammation.

Hydrocortisone binds to intracellular glucocorticoid receptors, altering gene transcription. This up‑regulates anti‑inflammatory proteins and suppresses pro‑inflammatory cytokines, while also providing the physiological glucocorticoid activity needed for normal metabolic and stress responses.

The specific dose of Hydrokortison Tiofarma is determined by the prescribing clinician based on the patient’s diagnosis, severity, age, weight, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for hydrocortisone in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician in consultation with the patient.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Hydrocortisone has a relatively short half‑life and mimics natural cortisol, making it suitable for physiologic replacement. Other glucocorticoids like prednisolone or dexamethasone have longer durations and greater potency, which may be preferred for certain inflammatory conditions but are less ideal for precise hormone replacement.

Store Hydrokortison Tiofarma at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Hydrokortison Tiofarma is taken orally, usually with water. The exact timing (e.g., morning or divided doses) and whether it should be taken with food depend on the prescriber’s guidance and the specific indication being treated.

Serious risks include severe infection due to immunosuppression, adrenal suppression if the drug is stopped abruptly, osteoporosis with long‑term use, hypertension, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for these complications.

Hydrokortison Tiofarma should be avoided in patients with known hypersensitivity to hydrocortisone or any excipients, in those with uncontrolled systemic infections, and in individuals where glucocorticoid therapy is contraindicated without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Hydrocortisone

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT