Product image of Hydrokortisoni Tiofarma (Hydrocortisone) supplied by GNH India

Hydrokortisoni Tiofarma

Active Ingredient:
Hydrocortisone
Origin:
EU

Hydrokortisoni Tiofarma (Hydrocortisone)

Hydrocortisone, the active ingredient in Hydrokortisoni Tiofarma, is a corticosteroid presented as an oral formulation for oral use. It is employed to replace deficient cortisol in adrenal insufficiency and to reduce inflammation in various autoimmune and inflammatory disorders.

GNH India supplies Hydrokortisoni Tiofarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Tiofarma B.V.

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Indications & Clinical Uses

Hydrocortisone acts on the glucocorticoid pathway to modulate inflammation and replace cortisol.

  • Adrenal insufficiency: restores physiologic cortisol levels and prevents adrenal crisis.
  • Congenital adrenal hyperplasia: suppresses excess androgen production and supports normal growth.
  • Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
  • Severe allergic dermatitis: diminishes skin inflammation and pruritus.

How It Works

  • Hydrocortisone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and regulates gene transcription. This action up‑regulates anti‑inflammatory proteins and down‑regulates pro‑inflammatory cytokines, leading to reduced immune cell activation, decreased vascular permeability, and suppression of adrenal cortisol production when administered exogenously.

Side Effects

Hydrocortisone may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Increased appetite and weight gain.
  • Fluid retention and mild edema.
  • Elevated blood glucose levels.
  • Mood changes such as irritability or euphoria.
  • Insomnia or difficulty sleeping.
  • Gastro‑intestinal discomfort.

Serious or Rare Side Effects

  • Adrenal suppression leading to crisis on abrupt withdrawal.
  • Severe infections due to immunosuppression.
  • Cushingoid appearance with facial rounding and striae.
  • Osteoporosis and increased fracture risk.
  • Peptic ulcer disease or gastrointestinal bleeding.
  • Psychosis or severe mood disorders.

Precautions & Warnings

When prescribing hydrocortisone, clinicians should consider several safety measures.

  • Assess adrenal function: evaluate baseline cortisol before initiating therapy.
  • Monitor blood glucose: adjust antidiabetic treatment as needed.
  • Use the lowest effective dose: limit duration to reduce systemic exposure.
  • Avoid abrupt discontinuation: taper gradually to prevent adrenal crisis.
  • Caution in active infection: evaluate risk‑benefit before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Hydrocortisone can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase glucocorticoid levels.
  • Anticoagulants (e.g., warfarin): enhanced anticoagulant effect, risk of bleeding.
  • NSAIDs: additive risk of gastrointestinal ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce hydrocortisone exposure.
  • Antidiabetic agents: possible need for dose adjustment due to hyperglycaemia.
  • ACE inhibitors or ARBs: monitor for sodium retention and hypertension.

Frequently Asked Questions

Hydrokortisoni Tiofarma contains hydrocortisone, which is prescribed to treat adrenal insufficiency, congenital adrenal hyperplasia, rheumatoid arthritis, and severe allergic skin conditions. It works by replacing deficient cortisol and reducing inflammation in these disorders.

Hydrocortisone binds to glucocorticoid receptors inside cells, influencing gene expression. This results in increased production of anti‑inflammatory proteins and suppression of pro‑inflammatory cytokines, thereby decreasing immune activation, reducing swelling, and providing cortisol replacement when endogenous production is insufficient.

The exact dosage of Hydrokortisoni Tiofarma is determined by the prescribing clinician based on the patient’s condition, severity, age, and response to therapy. Only a qualified healthcare professional should set the dose and schedule.

Safety data for hydrocortisone in pregnancy and lactation are limited. The prescriber must weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To request Hydrokortisoni Tiofarma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydrocortisone has a relatively short half‑life and mimics natural cortisol, making it suitable for physiologic replacement. Other glucocorticoids such as prednisolone or dexamethasone are more potent and have longer durations, often chosen for stronger anti‑inflammatory effects but requiring careful tapering.

Store Hydrokortisoni Tiofarma at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability.

Hydrokortisoni Tiofarma is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The exact method of administration (e.g., with water, timing relative to meals) should follow the healthcare professional’s instructions.

Serious risks include adrenal suppression leading to crisis if the drug is stopped abruptly, severe infections due to immunosuppression, Cushingoid changes, osteoporosis, and rare psychiatric effects such as psychosis. Patients should be monitored closely for these events.

Hydrokortisoni Tiofarma is contraindicated in patients with known hypersensitivity to hydrocortisone or any excipients, and in those with systemic fungal infections that require antifungal therapy. Caution is also advised for individuals with uncontrolled diabetes, active severe infections, or recent gastrointestinal ulceration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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