Product image of Hydrokortyzon Allefin (Hydrocortisone Acetate) supplied by GNH India

Hydrokortyzon Allefin

Active Ingredient:
Hydrocortisone Acetate
Origin:
EU

Hydrokortyzon Allefin (Hydrocortisone Acetate)

Hydrocortisone Acetate, the active ingredient in Hydrokortyzon Allefin, is a corticosteroid presented as a topical formulation for skin application. It treats inflammatory skin conditions such as eczema, dermatitis and psoriasis in adults and children.

GNH India supplies Hydrokortyzon Allefin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

  • Hydrocortisone Acetate is used to manage inflammatory skin disorders by reducing local inflammation.
  • Eczema: reduces redness, itching and swelling.
  • Dermatitis: alleviates symptoms and promotes healing.
  • Psoriasis: decreases plaque formation and inflammation.
  • Other inflammatory skin conditions: provides symptomatic relief.

How It Works

  • Hydrocortisone acetate penetrates the epidermis and binds to intracellular glucocorticoid receptors. The receptor complex translocates to the nucleus, where it modulates gene transcription, suppressing the synthesis of pro‑inflammatory cytokines, prostaglandins and leukotrienes, thereby decreasing local inflammation and immune activation.

Side Effects

Topical hydrocortisone acetate can cause a range of local and systemic reactions.

Common Side Effects

  • Skin irritation or burning sensation at the application site.
  • Pruritus or mild itching.
  • Dryness or peeling of the treated skin.
  • Folliculitis or acne‑like eruptions.
  • Mild erythema.

Serious or Rare Side Effects

  • Allergic contact dermatitis with severe redness and swelling.
  • Skin atrophy or thinning with prolonged use.
  • Hypopigmentation of the treated area.
  • Systemic absorption leading to adrenal suppression.
  • Secondary bacterial or fungal infection of the skin.
  • Anaphylactic reaction in highly sensitised individuals.

Precautions & Warnings

  • Use hydrocortisone acetate with attention to patient‑specific factors and application conditions.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown; consider potential exposure to infant.
  • Age: apply cautiously in children; monitor for systemic effects.
  • Application area: avoid extensive use on large body surfaces or broken skin to limit systemic absorption.
  • Concurrent infection: do not apply to infected skin without medical advice.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Topical hydrocortisone acetate may interact with other systemic or topical agents, altering efficacy or safety.

Major Interactions (Avoid)

  • Systemic corticosteroids: increased risk of systemic glucocorticoid effects.
  • Potent CYP3A4 inhibitors: may raise systemic exposure from skin absorption.
  • Live vaccines: topical steroids can diminish immune response.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., azoles): may increase local irritation.
  • Antibiotic ointments: may alter normal skin flora and affect healing.
  • Other topical immunosuppressants: combined use may enhance immunosuppression.

Frequently Asked Questions

Hydrokortyzon Allefin contains hydrocortisone acetate, a topical corticosteroid indicated for inflammatory skin disorders such as eczema, dermatitis and psoriasis. It helps reduce redness, itching, swelling and plaque formation by modulating local immune responses.

Hydrocortisone acetate penetrates the epidermis and binds to intracellular glucocorticoid receptors. This complex alters gene transcription, decreasing the production of inflammatory mediators like cytokines, prostaglandins and leukotrienes, which results in reduced inflammation and immune activity at the site of application.

The appropriate dose and frequency of Hydrokortyzon Allefin are determined by the prescribing healthcare professional based on the severity of the skin condition, patient age, and treatment area. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety data for hydrocortisone acetate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and import documentation.

Hydrokortyzon Allefin delivers hydrocortisone acetate, a low‑ to medium‑potency glucocorticoid. Compared with higher‑potency steroids such as betamethasone or clobetasol, it offers a milder anti‑inflammatory effect with a lower risk of skin atrophy, making it suitable for sensitive areas and long‑term use under medical supervision.

Store Hydrokortyzon Allefin at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Apply a thin layer of the topical preparation to the affected skin area as directed by the prescriber, usually 1–2 times daily. Gently massage until the product is absorbed, and wash hands before and after application unless the hands are the treatment site.

Serious risks include skin atrophy, hypopigmentation, systemic absorption leading to adrenal suppression, secondary infections, and rare allergic reactions such as anaphylaxis. Patients should report any severe skin changes, signs of infection, or systemic symptoms to their healthcare provider promptly.

Hydrokortyzon Allefin should be avoided in individuals with known hypersensitivity to hydrocortisone acetate or any formulation excipients, in patients with untreated fungal, bacterial or viral skin infections, and in those where systemic corticosteroid therapy is contraindicated without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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