Product image of Hydromed (Hydrochlorothiazide) supplied by GNH India

Hydromed

Active Ingredient:
Hydrochlorothiazide
Origin:
EU

Hydromed (Hydrochlorothiazide)

Hydrochlorothiazide, the active ingredient in Hydromed, is a thiazide diuretic presented as an oral tablet for oral administration. It works by promoting the excretion of sodium and water, thereby helping to lower elevated blood pressure and to decrease fluid retention associated with edema and related cardiovascular conditions.

GNH India supplies Hydromed as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics across global markets while adhering to stringent quality and regulatory standards and supporting reliable medication access for patients worldwide.

Manufacturer / TM Owner

Medilink A/S

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Indications & Clinical Uses

Hydrochlorothiazide is a thiazide diuretic that reduces extracellular fluid volume, making it useful in several cardiovascular conditions.

  • Hypertension: lowers systemic blood pressure by decreasing plasma volume.
  • Edema: reduces fluid accumulation in peripheral tissues, improving swelling.
  • Congestive heart failure: assists in fluid management and symptom relief.

How It Works

  • Hydrochlorothiazide inhibits the Na+/Cl- symporter located in the distal convoluted tubule of the nephron. By blocking this transporter, sodium and chloride reabsorption are reduced, leading to increased urinary excretion of sodium, chloride, and water. The resulting decrease in extracellular fluid volume lowers cardiac output and systemic vascular resistance, contributing to blood pressure reduction and edema resolution.

Side Effects

Hydrochlorothiazide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Increased urination: more frequent need to void.
  • Dizziness or light‑headedness, especially on standing.
  • Electrolyte imbalance: low potassium or sodium levels.
  • Elevated blood glucose: may affect diabetic control.
  • Gout flare: increased uric acid concentrations.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Severe dehydration: marked fluid loss leading to hypotension.
  • Acute kidney injury: sudden decline in renal function.
  • Life‑threatening electrolyte disturbances: severe hypokalemia or hyponatremia.
  • Pancreatitis: inflammation of the pancreas.
  • Anaphylactic reaction: rare but potentially fatal allergy.
  • Blood dyscrasias: abnormal blood cell counts such as agranulocytosis.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Monitor electrolytes: check serum potassium, sodium, and magnesium regularly.
  • Assess renal function: evaluate creatinine clearance and adjust use if impaired.
  • Use caution in diabetes: may worsen glycemic control, requiring closer monitoring.
  • Adjust dose in the elderly: start low and titrate slowly due to increased sensitivity.
  • Avoid in severe hepatic impairment: risk of accumulation and toxicity.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Hydrochlorothiazide can affect the pharmacokinetics or pharmacodynamics of several medicines.

Major Interactions (Avoid)

  • Lithium: concurrent use can increase lithium levels and toxicity.
  • Cyclosporine: combined therapy may heighten nephrotoxic risk.
  • NSAIDs (e.g., ibuprofen): may reduce diuretic efficacy and impair renal function.
  • ACE inhibitors/ARBs: can cause unpredictable potassium shifts.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents (insulin, sulfonylureas): may require dose reduction due to enhanced hypoglycaemic effect.
  • Digoxin: risk of toxicity may increase with electrolyte disturbances.
  • Warfarin: potentiation of anticoagulant effect may occur.
  • Quinolone antibiotics: may increase seizure risk in susceptible patients.

Frequently Asked Questions

Hydromed contains hydrochlorothiazide, a thiazide diuretic that is prescribed to lower high blood pressure and to reduce excess fluid accumulation in conditions such as peripheral edema. It is commonly used in patients with hypertension and in those who need to manage swelling caused by heart, liver, or kidney disorders.

Hydrochlorothiazide acts on the distal convoluted tubule of the kidney by blocking the sodium‑chloride symporter. This inhibition reduces reabsorption of sodium and chloride, leading to increased urinary excretion of these ions together with water. The resulting decrease in extracellular fluid volume lowers cardiac output and systemic vascular resistance, helping to control blood pressure and edema.

The appropriate dose of Hydromed is individualized by the prescribing clinician based on the patient’s medical condition, response to therapy, renal function, and electrolyte status. Dosage may be started low and adjusted as needed, but exact strength and frequency should only be set by a qualified healthcare professional.

Safety data for hydrochlorothiazide in pregnancy are limited, and the drug is generally used only if the potential benefit outweighs the risk to the fetus. It is excreted in breast milk, so caution is advised for nursing mothers. Physicians should evaluate each case carefully and discuss possible alternatives.

To request Hydromed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing a formal quotation that includes pricing, availability, shipping terms, and any necessary import documentation.

Hydromed (hydrochlorothiazide) belongs to the thiazide diuretic class, which lowers blood pressure primarily by reducing fluid volume. Compared with ACE inhibitors or calcium‑channel blockers, thiazides are often less expensive and can be combined with other agents for additive effect. However, they may cause electrolyte disturbances that are less common with some alternative classes.

Hydromed should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments to maintain tablet integrity.

Hydromed is taken orally, usually as a tablet swallowed whole with a full glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any specific dietary considerations.

The most critical risks include severe electrolyte imbalances such as hypokalemia or hyponatremia, which can lead to cardiac arrhythmias, and acute kidney injury, especially in patients with pre‑existing renal impairment. Rare but serious reactions may involve anaphylaxis, pancreatitis, or profound dehydration requiring immediate medical attention.

Hydromed is contraindicated in patients with known hypersensitivity to hydrochlorothiazide or other sulfonamide-derived drugs. It should also be avoided in individuals with anuria, severe renal or hepatic impairment, and in those with significant electrolyte disturbances that have not been corrected. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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