Product image of Hydroxocobalamin Alternova (Hydroxocobalamin Chloride) supplied by GNH India

Hydroxocobalamin Alternova

Active Ingredient:
Hydroxocobalamin Chloride
Origin:
EU

Hydroxocobalamin Alternova (Hydroxocobalamin Chloride)

Hydroxocobalamin, the active ingredient in Hydroxocobalamin Alternova, is a Vitamin B12 (cobalamin) preparation presented as an injectable solution for intramuscular use. It treats vitamin B12 deficiency, pernicious anemia, and can serve as an antidote for cyanide poisoning in appropriate patients.

GNH India supplies Hydroxocobalamin Alternova as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alternova A/S

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Indications & Clinical Uses

Hydroxocobalamin Alternova is used to address disorders related to vitamin B12 deficiency and cyanide toxicity.

  • Vitamin B12 deficiency: restores normal B12 levels and supports hematopoiesis.
  • Pernicious anemia: corrects anemia by providing bioavailable cobalamin.
  • Cyanide poisoning: binds cyanide to form cyanocobalamin, facilitating detoxification and excretion.

How It Works

  • Hydroxocobalamin is converted intracellularly to methylcobalamin and adenosylcobalamin, serving as essential cofactors for methionine synthase and methylmalonyl‑CoA mutase. These enzymes enable DNA synthesis, myelin formation, and conversion of homocysteine to methionine. In cyanide poisoning, hydroxocobalamin directly binds cyanide ions, forming the stable cyanocobalamin complex that is eliminated renally.

Side Effects

Hydroxocobalamin Alternova may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Injection site pain or erythema.
  • Mild headache.
  • Transient flushing or warmth.
  • Nausea or mild gastrointestinal upset.
  • Low‑grade fever.
  • Dizziness.

Serious or Rare Side Effects

  • Anaphylactic reaction or severe hypersensitivity.
  • Hypotension or cardiovascular collapse.
  • Severe rash or Stevens‑Johnson syndrome.
  • Hemolytic anemia.
  • Acute renal impairment.
  • Pulmonary edema.

Precautions & Warnings

When using Hydroxocobalamin Alternova, consider the following precautions.

  • Renal impairment: monitor patients with severe kidney disease.
  • Pregnancy: use only if clearly needed after risk‑benefit assessment.
  • Allergy: avoid in patients with known hypersensitivity to cobalamin or formulation components.
  • Concurrent cyanide exposure: ensure appropriate dosing and monitoring.
  • Drug interactions: review concomitant medications for potential effects on B12 metabolism.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hydroxocobalamin may interact with several medicines; categorize the significance.

Major Interactions (Avoid)

  • Nitrous oxide anesthesia: can exacerbate functional B12 deficiency.
  • Methotrexate: may increase risk of hematologic toxicity.
  • Cytotoxic chemotherapy agents: may require dose adjustments.

Moderate Interactions (Monitor Closely)

  • Metformin: may reduce B12 absorption, monitor levels.
  • Proton pump inhibitors: may affect B12 status, periodic assessment advised.
  • Anticonvulsants (e.g., phenytoin): may interfere with B12 metabolism.

Frequently Asked Questions

Hydroxocobalamin Alternova is indicated for the treatment of vitamin B12 deficiency, including pernicious anemia, and as an antidote for cyanide poisoning. It provides a readily bioavailable form of cobalamin to restore normal metabolic functions in these conditions.

Hydroxocobalamin serves as a precursor to the active coenzyme forms methylcobalamin and adenosylcobalamin. These cofactors are essential for enzymes such as methionine synthase and methylmalonyl‑CoA mutase, which support DNA synthesis, red blood cell formation, and myelin production. In cyanide poisoning, hydroxocobalamin directly binds cyanide to form cyanocobalamin, which is safely excreted.

The specific dose and administration schedule of Hydroxocobalamin Alternova are determined by the prescribing clinician based on the patient’s condition, severity, and clinical response. Healthcare professionals should follow local guidelines and product labeling when prescribing.

Safety data for Hydroxocobalamin Alternova in pregnancy and lactation are limited. It should only be used when clearly needed, after a careful risk‑benefit assessment by the treating physician. Breastfeeding mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and import documentation.

Hydroxocobalamin is a natural, long‑acting form of vitamin B12 that can be converted to both methylcobalamin and adenosylcobalamin, offering broader metabolic support than cyanocobalamin. It also has the unique ability to act as a cyanide antidote, a property not shared by most other B12 preparations.

Hydroxocobalamin Alternova should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution to maintain stability.

The product is supplied as an injectable solution for intramuscular injection. Administration is performed by a qualified healthcare professional using aseptic technique, typically into the deltoid or gluteal muscle, according to the prescribing information.

Serious adverse reactions, although rare, include anaphylaxis, severe hypotension, hemolytic anemia, and pulmonary edema. Immediate medical attention is required if any signs of a severe allergic reaction or cardiovascular compromise occur after administration.

Patients with a known hypersensitivity to hydroxocobalamin or any component of the formulation should avoid this product. Caution is also advised for individuals with severe renal impairment, and it should be used only when clearly indicated in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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