Product image of Hydroxocobalamin G.L. Pharma (Hydroxocobalamin Acetate) supplied by GNH India

Hydroxocobalamin G.L. Pharma

Active Ingredient:
Hydroxocobalamin Acetate
Origin:
EU

Hydroxocobalamin G.L. Pharma (Hydroxocobalamin Acetate)

Hydroxocobalamin, the active ingredient in Hydroxocobalamin G.L. Pharma, is a vitamin B12 presented as an injectable solution for intramuscular use. It treats vitamin B12 deficiency, cobalamin deficiency anemia, and megaloblastic anemia in patients who require parenteral supplementation.

GNH India supplies Hydroxocobalamin G.L. Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Hydroxocobalamin is used to correct deficiencies in the vitamin B12 metabolic pathway and associated anemic conditions.

  • Vitamin B12 deficiency: restores normal B12 levels and supports hematopoiesis.
  • Cobalamin deficiency anemia: corrects anemia by enabling red blood cell formation.
  • Megaloblastic anemia: promotes DNA synthesis to resolve macrocytic red cells.

How It Works

  • Hydroxocobalamin is converted intracellularly to the active co‑enzyme forms methylcobalamin and adenosylcobalamin. These act as essential cofactors for methionine synthase and methylmalonyl‑CoA mutase, enzymes that drive homocysteine remethylation, fatty‑acid metabolism, DNA synthesis and red blood cell maturation, thereby correcting cobalamin‑dependent metabolic defects.

Side Effects

Hydroxocobalamin may cause a range of adverse reactions after intramuscular injection.

Common Side Effects

  • Injection‑site pain or erythema.
  • Mild fever or chills.
  • Headache.
  • Nausea or vomiting.
  • Dizziness.
  • Transient hypertension.

Serious or Rare Side Effects

  • Anaphylactic reaction.
  • Severe hypotension.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Acute hemolysis.
  • Severe respiratory distress.
  • Persistent high blood pressure.

Precautions & Warnings

When using Hydroxocobalamin, consider the following safety measures.

  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: unknown effects; weigh benefits against potential risks.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Concomitant cyanide therapy: monitor for potential assay interference.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hydroxocobalamin may interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • High‑dose cyanide antidote regimens: may reduce hydroxocobalamin effectiveness.
  • Nitrite compounds: can precipitate methemoglobinemia.

Moderate Interactions (Monitor Closely)

  • Metformin or proton‑pump inhibitors: may affect B12 absorption and require monitoring.
  • Anticonvulsants such as phenytoin or phenobarbital: can lower B12 levels.
  • Trimethoprim‑sulfamethoxazole: may interfere with cobalamin metabolism.
  • Oral antibiotics (e.g., tetracyclines): may reduce gut flora‑mediated B12 synthesis.

Frequently Asked Questions

Hydroxocobalamin G.L. Pharma is an injectable vitamin B12 preparation used to treat vitamin B12 deficiency, cobalamin deficiency anemia, and megaloblastic anemia. It provides the necessary cobalamin cofactor for enzymes involved in DNA synthesis and red blood cell formation, helping to correct the underlying metabolic deficit.

Hydroxocobalamin is converted inside cells to methylcobalamin and adenosylcobalamin, the active co‑enzyme forms of vitamin B12. These cofactors support methionine synthase and methylmalonyl‑CoA mutase, enzymes essential for homocysteine remethylation, fatty‑acid metabolism, DNA synthesis, and maturation of red blood cells, thereby reversing B12‑related metabolic disturbances.

The dosage of Hydroxocobalamin G.L. Pharma is determined by the prescribing clinician based on the patient’s clinical condition, severity of deficiency, and response to therapy. The prescriber will decide the appropriate amount, frequency, and duration of intramuscular administration.

Safety data for Hydroxocobalamin in pregnancy and lactation are limited. It should only be used when clearly needed, and the prescriber must weigh the potential benefits against any unknown risks to the mother and infant.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if required) and import documentation.

Hydroxocobalamin has a longer plasma half‑life than cyanocobalamin and can be stored in body tissues, providing more sustained B12 levels. It also serves as an antidote for cyanide poisoning, a property not shared by most other B12 formulations, making it a preferred choice for certain clinical scenarios.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use, and discard any solution that appears discolored or contains particles.

Hydroxocobalamin G.L. Pharma is administered by intramuscular injection, typically into the deltoid or gluteal muscle. The injection should be performed by a qualified healthcare professional using aseptic technique to minimize the risk of infection or local irritation.

Serious risks include anaphylactic reactions, severe hypotension, and rare severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should be monitored for signs of allergic response, and any severe reaction requires immediate medical attention.

Individuals with known hypersensitivity to hydroxocobalamin or any component of the formulation should avoid its use. Additionally, patients receiving concurrent cyanide antidote therapy or those with severe renal impairment should be evaluated carefully by a healthcare professional before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.