Product image of Hydroxocobalamin G.L. Pharma (Hydroxocobalamin Acetate) supplied by GNH India

Hydroxocobalamin G.L. Pharma

Active Ingredient:
Hydroxocobalamin Acetate
Origin:
EU

Hydroxocobalamin G.L. Pharma (Hydroxocobalamin Acetate)

Hydroxocobalamin, the active ingredient in Hydroxocobalamin G.L. Pharma, is a cobalamin (vitamin B12) presented as an injectable solution for intramuscular or subcutaneous use. It is used to treat vitamin B12 deficiency, including pernicious anemia and malabsorption‑related deficiency, in patients of all ages.
GNH India supplies Hydroxocobalamin G.L. Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Hydroxocobalamin is a vitamin B12 supplement that restores normal cobalamin levels in disorders of deficiency.

  • Cobalamin deficiency: replenishes depleted vitamin B12 stores and supports hematologic recovery.
  • Pernicious anemia: provides the necessary cofactor for red blood cell formation when intrinsic factor is lacking.
  • Malabsorption‑related deficiency: bypasses gastrointestinal absorption defects to deliver active B12 directly into the bloodstream.

How It Works

  • Hydroxocobalamin acts as a cofactor for the enzymes methionine synthase and methylmalonyl‑CoA mutase. By facilitating the conversion of homocysteine to methionine and the metabolism of odd‑chain fatty acids, it supports DNA synthesis, myelin formation, and normal red blood cell production. The injected form directly increases intracellular cobalamin concentrations, overcoming absorption barriers.

Side Effects

Hydroxocobalamin may cause adverse reactions, most of which are mild and transient.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the administration site.
  • Headache: occasional transient headache following injection.
  • Nausea: mild gastrointestinal upset.
  • Dizziness: brief episodes of light‑headedness.
  • Mild flushing: temporary reddening of the skin.

Serious or Rare Side Effects

  • Anaphylactic reaction: rare but potentially life‑threatening hypersensitivity.
  • Severe hypotension: abrupt drop in blood pressure after injection.
  • Pulmonary edema: rare accumulation of fluid in the lungs.
  • Thromboembolic events: extremely uncommon clot formation.
  • Acute hemolysis: rare destruction of red blood cells.

Precautions & Warnings

Hydroxocobalamin should be used with attention to patient history and handling requirements.

  • Allergy assessment: avoid use in patients with known hypersensitivity to cobalamin preparations.
  • Cardiovascular monitoring: observe for hypotension or arrhythmias in high‑risk patients.
  • Renal function: adjust use in severe renal impairment as accumulation may occur.
  • Pregnancy and lactation: prescribe only if clearly needed, after risk‑benefit evaluation.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hydroxocobalamin may interact with certain medications, altering efficacy or safety.

Major Interactions (Avoid)

  • Metformin: may reduce vitamin B12 absorption, requiring monitoring.
  • Proton pump inhibitors: long‑term use can impair cobalamin uptake.
  • Chloramphenicol: may potentiate hematologic toxicity.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, carbamazepine): may increase vitamin B12 requirements.
  • Nitrous oxide anesthesia: can inactivate cobalamin, necessitating supplementation.
  • Oral contraceptives: may slightly alter B12 metabolism.

Frequently Asked Questions

Hydroxocobalamin G.L. Pharma is a vitamin B12 supplement used to treat cobalamin deficiency, including conditions such as pernicious anemia and deficiency caused by malabsorption. By restoring normal B12 levels, it supports red blood cell formation, neurological function, and DNA synthesis.

Hydroxocobalamin serves as a cofactor for methionine synthase and methylmalonyl‑CoA mutase, enzymes essential for converting homocysteine to methionine and for fatty‑acid metabolism. This activity enables proper DNA synthesis, myelin formation, and red blood cell production, correcting the metabolic disturbances caused by B12 deficiency.

The dosage of Hydroxocobalamin G.L. Pharma is determined by the prescribing clinician based on the patient’s specific condition, severity of deficiency, and route of administration. Healthcare providers set the appropriate dose and schedule according to clinical guidelines and individual patient needs.

Hydroxocobalamin may be used during pregnancy or lactation only when clearly needed and after a careful risk‑benefit assessment by the prescriber. Vitamin B12 is essential for fetal development, but the decision to treat should be individualized and discussed with a healthcare professional.

To order Hydroxocobalamin G.L. Pharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

Hydroxocobalamin is a naturally occurring form of vitamin B12 with a longer plasma half‑life compared with cyanocobalamin, allowing more sustained B12 levels. It is often preferred for patients with severe deficiency or malabsorption because it can be administered intramuscularly or subcutaneously, bypassing gastrointestinal absorption.

Hydroxocobalamin G.L. Pharma should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the product. If the solution appears discolored or contains particles, it should not be used.

Hydroxocobalamin G.L. Pharma is administered by a healthcare professional via intramuscular or subcutaneous injection. The injection site is typically the deltoid or gluteal muscle, and the volume and concentration are determined by the prescriber based on the therapeutic indication.

The most serious risks include rare anaphylactic reactions, severe hypotension, pulmonary edema, and thromboembolic events. Patients should be monitored during and after injection for signs of allergic response, cardiovascular changes, or respiratory distress, and immediate medical attention should be sought if serious symptoms occur.

Hydroxocobalamin G.L. Pharma should be avoided in individuals with a known hypersensitivity to cobalamin preparations or any of the excipients in the formulation. Caution is also advised for patients with severe renal impairment, uncontrolled cardiovascular disease, or those who have experienced previous severe reactions to vitamin B12 injections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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