Product image of Hydroxocobalamin G.L. Pharma (Hydroxocobalamin Acetate) supplied by GNH India

Hydroxocobalamin G.L. Pharma

Active Ingredient:
Hydroxocobalamin Acetate
Origin:
EU

Hydroxocobalamin G.L. Pharma (Hydroxocobalamin Acetate)

Hydroxocobalamin, the active ingredient in Hydroxocobalamin G.L. Pharma, is a vitamin B12 (cobalamin) presented as an injectable solution for intramuscular or subcutaneous use. It treats vitamin B12 deficiency, including pernicious anemia, and is employed as an antidote in cyanide poisoning.
GNH India supplies Hydroxocobalamin G.L. Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Hydroxocobalamin is a vitamin B12 supplement used to correct deficiency states and related disorders.

  • Vitamin B12 deficiency: restores normal hematologic and neurologic function.
  • Pernicious anemia: provides essential cobalamin for red blood cell production.
  • Cyanide poisoning: binds cyanide to form cyanocobalamin, facilitating detoxification.

How It Works

  • Hydroxocobalamin is converted intracellularly to methylcobalamin and adenosylcobalamin, serving as cofactors for methionine synthase and methylmalonyl‑CoA mutase. These enzymes support DNA synthesis, myelin formation, and normal neurologic function, while hydroxocobalamin also directly binds cyanide to produce cyanocobalamin, aiding detoxification.

Side Effects

Adverse reactions may occur following administration of hydroxocobalamin.

Common Side Effects

  • Injection site pain or erythema.
  • Mild headache.
  • Nausea or vomiting.
  • Dizziness.
  • Low‑grade fever.
  • Transient flushing.

Serious or Rare Side Effects

  • Anaphylaxis or severe hypersensitivity.
  • Hypotension.
  • Hemolysis.
  • Stevens‑Johnson syndrome.
  • Thromboembolic events.
  • Severe skin reactions.

Precautions & Warnings

Hydroxocobalamin should be used with appropriate clinical oversight.

  • Assess baseline B12 status: confirm deficiency before initiating therapy.
  • Monitor for allergic reactions: discontinue if severe hypersensitivity occurs.
  • Use caution in renal impairment: adjust monitoring as needed.
  • Avoid in patients with known cobalamin hypersensitivity.
  • Follow protocol for cyanide poisoning: administer under emergency guidelines.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hydroxocobalamin may interact with certain medications.

Major Interactions (Avoid)

  • Concurrent nitrous oxide anesthesia: may exacerbate functional B12 deficiency.
  • High‑dose methotrexate: potential interference with cobalamin metabolism.

Moderate Interactions (Monitor Closely)

  • Metformin: may reduce B12 absorption; monitor levels.
  • Proton pump inhibitors: may impair B12 uptake; assess status.
  • Anticonvulsants (e.g., phenytoin): may affect B12 levels; consider supplementation.

Frequently Asked Questions

Hydroxocobalamin G.L. Pharma is an injectable vitamin B12 formulation used to treat vitamin B12 deficiency, including pernicious anemia, and to act as an antidote in cases of cyanide poisoning.

Hydroxocobalamin is converted to active cobalamin co‑factors that support methionine synthase and methylmalonyl‑CoA mutase, essential enzymes for DNA synthesis, red blood cell formation, and neurologic function, while also binding cyanide to form non‑toxic cyanocobalamin.

The prescribed dose and administration schedule are determined by the treating clinician based on the specific indication, patient condition, and clinical guidelines. Dosage should not be altered without medical advice.

Safety data for Hydroxocobalamin in pregnancy and lactation are limited. Its use should be considered only if the potential benefit justifies any potential risk to the fetus or infant, and it must be prescribed by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Hydroxocobalamin differs from cyanocobalamin and methylcobalamin in its longer plasma half‑life and its ability to directly bind cyanide. It is often preferred for treating cyanide poisoning and for patients requiring sustained B12 levels, whereas other forms may be used for routine supplementation.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

Hydroxocobalamin is administered by a healthcare professional via intramuscular or subcutaneous injection, following aseptic technique. The injection site and route are selected based on the clinical indication and patient factors.

Serious adverse reactions include anaphylaxis, severe hypersensitivity, hypotension, hemolysis, Stevens‑Johnson syndrome, and rare thromboembolic events. Immediate medical attention is required if any of these symptoms occur.

Patients with known hypersensitivity to hydroxocobalamin or any component of the formulation should avoid its use. Caution is also advised for individuals with severe renal impairment or those receiving interacting medications without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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