Product image of Hydroxocobalamine Hcl Cf (Hydroxocobalamin Chloride) supplied by GNH India

Hydroxocobalamine Hcl Cf

Active Ingredient:
Hydroxocobalamin Chloride
Origin:
EU

Hydroxocobalamine Hcl Cf (Hydroxocobalamin Chloride)

Hydroxocobalamin chloride, the active ingredient in Hydroxocobalamine Hcl Cf, is a cobalamin (Vitamin B12) presented as an injectable solution for intramuscular and subcutaneous use. It treats vitamin B12 deficiency, pernicious anemia, and cyanide poisoning in patients requiring parenteral therapy.

GNH India supplies Hydroxocobalamine Hcl Cf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Centrafarm B.V.

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Indications & Clinical Uses

  • Hydroxocobalamin chloride is used to correct deficiencies and toxic exposures related to the cobalamin pathway.
  • Vitamin B12 deficiency: restores normal hematologic parameters and neurological function.
  • Pernicious anemia: provides the necessary cobalamin to correct anemia caused by intrinsic factor deficiency.
  • Cyanide poisoning: binds cyanide ions to form cyanocobalamin, facilitating detoxification and excretion.

How It Works

  • Hydroxocobalamin chloride supplies bioavailable cobalamin that serves as a cofactor for methionine synthase and methylmalonyl‑CoA mutase, essential enzymes in DNA synthesis and fatty‑acid metabolism. In cyanide poisoning, the molecule directly binds cyanide to produce cyanocobalamin, which is then eliminated, thereby reducing toxic cyanide levels.

Side Effects

Hydroxocobalamin chloride may cause a range of adverse reactions following injection.

Common Side Effects

  • Injection site pain or erythema
  • Mild fever or chills
  • Headache
  • Nausea or dizziness

Serious or Rare Side Effects

  • Anaphylactic reaction or severe hypersensitivity
  • Acute hypotension
  • Stevens‑Johnson syndrome or severe skin reactions
  • Hemolytic anemia, thrombocytopenia, or acute renal failure

Precautions & Warnings

  • Before initiating therapy, consider patient‑specific factors and monitor for reactions.
  • Assess baseline B12 status: confirm deficiency before treatment.
  • Monitor for allergic reactions: observe injection site and systemic signs.
  • Use caution in renal impairment: adjust monitoring as needed.
  • Avoid in known hypersensitivity to cobalamin or formulation components.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hydroxocobalamin may interact with other agents that affect vitamin B12 metabolism or cause additive toxicity.

Major Interactions (Avoid)

  • Metformin: may exacerbate B12 deficiency, monitor levels.
  • Chloramphenicol: combined bone‑marrow suppression risk, use with caution.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may reduce oral B12 absorption, though injection bypasses GI tract; monitor clinical response.
  • Anticonvulsants (phenytoin, carbamazepine): may increase B12 turnover, watch for deficiency signs.
  • Nitrous oxide exposure: inactivates cobalamin, consider supplemental dosing.

Frequently Asked Questions

Hydroxocobalamine Hcl Cf is indicated for the treatment of vitamin B12 deficiency, including pernicious anemia, and for the emergency management of cyanide poisoning. It provides a parenteral source of cobalamin to correct hematologic and neurologic deficits or to bind cyanide for detoxification.

Hydroxocobalamin chloride supplies bioavailable cobalamin that acts as a cofactor for enzymes such as methionine synthase and methylmalonyl‑CoA mutase, supporting DNA synthesis and fatty‑acid metabolism. In cyanide poisoning, it directly binds cyanide ions to form cyanocobalamin, which is then eliminated, reducing toxic cyanide levels.

The specific dose and dosing schedule of Hydroxocobalamine Hcl Cf are determined by the prescribing clinician based on the patient’s condition, severity, and clinical response. Healthcare professionals should follow local guidelines and product labeling when prescribing.

Safety data for Hydroxocobalamine Hcl Cf in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. Clinicians should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Hydroxocobalamine is a natural form of vitamin B12 with a longer plasma half‑life compared with cyanocobalamin, making it useful for sustained correction of deficiency and for cyanide detoxification. Unlike cyanocobalamin, it can directly bind cyanide, offering an advantage in acute poisoning scenarios.

Hydroxocobalamine Hcl Cf should be stored at 2‑8 °C in a refrigerator, protected from light. The product must not be frozen or shaken, and it should remain in its original packaging until use to maintain stability.

The medication is supplied as an injectable solution for intramuscular or subcutaneous injection. Administration is performed by a qualified healthcare professional using aseptic technique, typically into a large muscle such as the gluteus or into subcutaneous tissue, according to the prescriber’s instructions.

Serious adverse reactions, although rare, include anaphylaxis, severe hypotension, Stevens‑Johnson syndrome, hemolytic anemia, thrombocytopenia, and acute renal failure. Immediate medical attention is required if any of these symptoms develop after administration.

Patients with known hypersensitivity to hydroxocobalamin, its salts, or any excipients in the formulation should not receive the product. Caution is also advised for individuals with severe renal impairment or those who have experienced severe allergic reactions to other cobalamin preparations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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