Product image of Hydroxycarbamid Eugia (Hydroxycarbamide) supplied by GNH India

Hydroxycarbamid Eugia

Active Ingredient:
Hydroxycarbamide
Origin:
EU

Hydroxycarbamid Eugia (Hydroxycarbamide)

Hydroxycarbamide, the active ingredient in Hydroxycarbamid Eugia, is an antimetabolite presented as an oral tablet for systemic administration. It is used to manage specific hematologic malignancies and blood disorders, including chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, and sickle cell disease, primarily in adult patients and may be prescribed by hematologists as part of a disease‑modifying regimen.

GNH India supplies Hydroxycarbamid Eugia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide with reliable logistics and regulatory support.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

  • Hydroxycarbamide is an antimetabolite used in the treatment of myeloproliferative disorders and sickle cell disease.
  • Chronic myelogenous leukemia: reduces leukemic cell proliferation and improves hematologic control.
  • Polycythemia vera: lowers red blood cell mass and decreases risk of thrombosis.
  • Essential thrombocythemia: normalizes platelet counts and reduces thrombotic complications.
  • Sickle cell disease: increases fetal hemoglobin production, decreasing vaso‑occlusive crises.

How It Works

  • Hydroxycarbamide inhibits ribonucleotide reductase, the enzyme responsible for converting ribonucleotides to deoxyribonucleotides. This depletion of deoxyribonucleotide pools limits DNA synthesis, causing S‑phase cell‑cycle arrest and preferentially targeting rapidly dividing malignant cells. In sickle cell disease, the drug also induces fetal hemoglobin, which interferes with sickling of red cells.

Side Effects

Hydroxycarbamid Eugia may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Hair thinning: temporary loss of scalp hair.
  • Skin discoloration: hyperpigmentation of the skin or nails.
  • Mouth ulcers: painful sores in the oral cavity.

Serious or Rare Side Effects

  • Bone marrow suppression: severe anemia, leukopenia, or thrombocytopenia requiring monitoring.
  • Renal toxicity: impaired kidney function manifested by increased creatinine.
  • Cutaneous ulcers: non‑healing skin lesions, especially on the lower extremities.

Precautions & Warnings

Hydroxycarbamid Eugia requires careful monitoring and specific safety measures.

  • Dose adjustment: modify dose based on complete blood count results.
  • Pregnancy: contraindicated in pregnancy (Category D) due to fetal risk.
  • Breastfeeding: avoid use while nursing because drug is excreted in milk.
  • Renal impairment: assess kidney function before initiating therapy.
  • Monitoring: perform regular CBC, liver and renal tests during treatment.
  • Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture and light.

Avoid Interactions

Hydroxycarbamid Eugia can interact with several medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Live vaccines: concurrent use may increase risk of infection.
  • Antiretroviral protease inhibitors: may increase hydroxycarbamide plasma levels.
  • Azathioprine: additive bone marrow suppression.

Moderate Interactions (Monitor Closely)

  • Allopurinol: may enhance toxicity, monitor blood counts.
  • Phenytoin: may reduce hydroxycarbamide efficacy, adjust dose if needed.
  • NSAIDs: may increase risk of renal dysfunction, monitor renal function.

Frequently Asked Questions

Hydroxycarbamid Eugia contains hydroxycarbamide, an antimetabolite indicated for chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia and sickle cell disease. It is prescribed to control abnormal blood cell proliferation and to increase fetal hemoglobin in sickle cell patients, improving disease outcomes.

Hydroxycarbamide blocks ribonucleotide reductase, an enzyme needed to produce deoxyribonucleotides for DNA synthesis. By depleting these building blocks, the drug halts DNA replication, causing cell‑cycle arrest in rapidly dividing malignant cells and raising fetal hemoglobin levels in sickle cell disease.

The dose of Hydroxycarbamid Eugia is individualized. A qualified prescriber determines the appropriate amount based on the specific indication, patient weight, renal function and laboratory monitoring. Dosage adjustments are made according to response and safety parameters.

Hydroxycarbamid Eugia is classified as Pregnancy Category D, indicating evidence of fetal risk. It is contraindicated during pregnancy and should not be used by nursing mothers because the drug is excreted in breast milk and may harm the infant.

To order Hydroxycarbamid Eugia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydroxycarbamid Eugia belongs to the antimetabolite class, whereas alternatives such as imatinib are tyrosine‑kinase inhibitors. Hydroxycarbamide is less targeted but effective for a broader range of myeloproliferative disorders and sickle cell disease, while newer agents may offer disease‑specific mechanisms with different safety profiles.

Hydroxycarbamid Eugia should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme humidity to maintain potency throughout its shelf life.

Hydroxycarbamid Eugia is taken orally, usually as a tablet swallowed whole with water. It is administered according to the prescriber’s schedule, which may involve daily or intermittent dosing based on the therapeutic goal and patient tolerance.

The most serious risks include bone‑marrow suppression leading to severe anemia, leukopenia or thrombocytopenia, renal toxicity manifested by decreased kidney function, and the development of non‑healing cutaneous ulcers. Regular laboratory monitoring is essential to detect these complications early.

Hydroxycarbamid Eugia should be avoided in pregnant women, nursing mothers, patients with severe pre‑existing bone‑marrow failure, known hypersensitivity to hydroxycarbamide, and individuals with uncontrolled renal impairment unless dose adjustments are made under specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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