Product image of Hydroxychloroquine Adamed (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquine Adamed

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquine Adamed (Hydroxychloroquine Sulfate)

Hydroxychloroquine, the active ingredient in Hydroxychloroquine Adamed, is an antimalarial presented as a tablet for oral use. It treats malaria, rheumatoid arthritis and systemic lupus erythematosus and is indicated for acute malaria episodes as well as long‑term management of these autoimmune disorders.

GNH India supplies Hydroxychloroquine Adamed as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to WHO‑GMP standards and provides reliable logistics for global distribution to healthcare providers. Ensuring timely delivery and product integrity across regions.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

  • Hydroxychloroquine is an antimalarial agent that also modulates immune activity in rheumatic diseases.
  • Malaria: effective treatment of acute malaria infections, reducing parasitic replication.
  • Rheumatoid arthritis: helps lower disease activity and joint inflammation in patients with RA.
  • Systemic lupus erythematosus: assists in controlling disease flares and cutaneous manifestations.

How It Works

  • Hydroxychloroquine accumulates in lysosomes, raising their pH and inhibiting enzymatic activity, which disrupts parasite heme polymerization and impairs autophagic processes. The drug also interferes with antigen presentation and Toll‑like receptor signaling, leading to reduced activation of immune cells and diminished production of pro‑inflammatory cytokines, thereby exerting immunomodulatory effects in autoimmune conditions. Additionally, hydroxychloroquine may affect calcium signaling in immune cells, contributing to its therapeutic profile.

Side Effects

Hydroxychloroquine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Headache
  • Skin rash

Serious or Rare Side Effects

  • Retinopathy leading to vision loss
  • Cardiomyopathy or arrhythmias
  • Severe hypoglycemia
  • Blood dyscrasias such as agranulocytosis
  • Neuropsychiatric disturbances

Precautions & Warnings

Before initiating therapy, consider the following precautions to ensure safe use of hydroxychloroquine.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Renal impairment: dose may need adjustment; monitor renal function.
  • Ophthalmologic monitoring: baseline eye exam and periodic follow‑up recommended.
  • Cardiac risk: assess QT interval and avoid in patients with known prolongation.
  • Concomitant drugs: review for interactions that may increase toxicity.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Hydroxychloroquine can interact with several medicines; awareness of these interactions helps prevent adverse events.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce absorption.
  • Quinidine and other class I antiarrhythmics: increase cardiotoxic risk.
  • Digoxin: may raise serum levels.
  • Cyclosporine: enhanced toxicity risk.
  • Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): increase hydroxychloroquine concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect.
  • Insulin or oral hypoglycemics: risk of hypoglycemia.
  • Other QT‑prolonging agents (e.g., azithromycin, fluoroquinolones): monitor cardiac rhythm.
  • Rifampin: may decrease hydroxychloroquine levels.
  • Zidovudine: potential additive hematologic toxicity.

Frequently Asked Questions

Hydroxychloroquine Adamed is prescribed for the treatment of acute malaria infections and for long‑term management of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, where it helps control disease activity and inflammation.

The drug accumulates in lysosomes, raising their pH and disrupting enzymatic processes that are essential for parasite survival and for antigen presentation. This interferes with malaria parasite replication and modulates immune signaling pathways, reducing inflammatory cytokine production in autoimmune diseases.

The appropriate dose of Hydroxychloroquine Adamed is determined by a qualified prescriber based on the patient’s specific condition, disease severity, renal function, and other clinical factors. Dosage adjustments are made according to professional medical guidelines.

Safety of hydroxychloroquine in pregnancy and lactation has not been definitively established. It may be used only when the potential benefit justifies any potential risk to the fetus or infant, and this decision should be made by the treating physician.

To request Hydroxychloroquine Adamed, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Hydroxychloroquine offers both antimalarial activity and immunomodulatory effects, distinguishing it from many DMARDs that lack antiparasitic action. Compared with newer agents, it has a well‑known safety profile but may require regular eye monitoring, whereas some alternatives have different risk considerations such as hepatotoxicity or higher infection risk.

Hydroxychloroquine Adamed tablets should be stored at ambient temperature, preferably below 25 °C, in their original packaging to protect from moisture and light. Keeping the product in a dry, cool place helps maintain its stability and potency.

Hydroxychloroquine Adamed is administered orally as a tablet. Patients should swallow the tablet with water, following the dosing schedule prescribed by their healthcare provider, and should not alter the route of administration without medical advice.

Serious adverse effects can include retinal toxicity leading to vision loss, cardiomyopathy or arrhythmias, severe hypoglycemia, and hematologic disorders such as agranulocytosis. Patients should be monitored regularly for visual changes, cardiac symptoms, and blood count abnormalities.

Hydroxychloroquine Adamed is contraindicated in individuals with known hypersensitivity to hydroxychloroquine or related compounds, pre‑existing retinopathy, severe cardiac disease with QT prolongation, and in patients for whom the drug’s risks outweigh any therapeutic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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