Product image of Hydroxychloroquine Sulfate Blackrock Pharmaceuticals (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquine Sulfate Blackrock Pharmaceuticals

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquine Sulfate Blackrock Pharmaceuticals (Hydroxychloroquine Sulfate)

Hydroxychloroquine sulfate, the active ingredient in Hydroxychloroquine Sulfate Blackrock Pharmaceuticals, is a quinoline antimalarial presented as an oral tablet for oral use. It treats malaria and modulates immune response in rheumatoid arthritis and systemic lupus erythematosus.

GNH India supplies Hydroxychloroquine Sulfate Blackrock Pharmaceuticals as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Blackrock Pharmaceuticals Limited

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Indications & Clinical Uses

Hydroxychloroquine sulfate is employed in diseases where it interferes with parasite metabolism or modulates immune activity.

  • Malaria: clears Plasmodium infection and prevents recurrence.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Systemic lupus erythematosus: diminishes disease activity and organ damage risk.

How It Works

  • Hydroxychloroquine inhibits lysosomal activity and autophagy, raising intralysosomal pH, which disrupts parasite heme polymerization and impairs antigen processing. It also interferes with Toll‑like receptor signaling, leading to reduced cytokine production and modulation of the immune response in autoimmune conditions.

Side Effects

Hydroxychloroquine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools, usually self‑limiting.
  • Skin rash: mild erythema or pruritus.
  • Visual disturbances: blurred vision or photophobia.

Serious or Rare Side Effects

  • Retinopathy: progressive vision loss requiring ophthalmologic monitoring.
  • Cardiomyopathy: heart rhythm abnormalities or reduced cardiac function.
  • Severe hypoglycemia: especially when combined with antidiabetic agents.
  • Hemolysis in G6PD deficiency: rapid red blood cell destruction.
  • Stevens‑Johnson syndrome: severe skin and mucosal reactions.

Precautions & Warnings

Hydroxychloroquine requires careful monitoring to minimize risks.

  • Pregnancy: Category C – weigh potential benefits against fetal risks.
  • Retinal monitoring: baseline and periodic eye exams are advised.
  • Cardiac assessment: ECG monitoring for QT prolongation in at‑risk patients.
  • G6PD deficiency: test before initiating therapy to avoid hemolysis.
  • Blood glucose: monitor closely if patient uses insulin or oral hypoglycemics.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Hydroxychloroquine can interact with several drug classes, affecting safety and efficacy.

Major Interactions (Avoid)

  • QT‑prolonging agents (e.g., azithromycin, quinidine): increase risk of cardiac arrhythmias.
  • Digoxin: hydroxychloroquine may raise digoxin serum levels, leading to toxicity.
  • Insulin or sulfonylureas: enhanced hypoglycemic effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase hydroxychloroquine concentrations.
  • CYP3A4 inducers (e.g., rifampin): may reduce drug exposure.
  • NSAIDs: may exacerbate gastrointestinal irritation.

Frequently Asked Questions

Hydroxychloroquine Sulfate is indicated for the treatment and prevention of malaria, as well as for managing autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. In malaria, it clears the parasite from the bloodstream, while in autoimmune diseases it helps reduce inflammation and disease activity.

The drug raises the pH inside lysosomes, disrupting parasite heme polymerization and interfering with antigen processing. It also modulates immune pathways by inhibiting Toll‑like receptor signaling, which reduces cytokine production and dampens the inflammatory response in autoimmune conditions.

The dosage of Hydroxychloroquine Sulfate is determined by the prescribing clinician based on the specific indication, patient weight, renal function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional and not adjust the dose on their own.

Hydroxychloroquine is classified as Pregnancy Category C, meaning potential benefits may justify use despite possible risks. It can cross the placenta and is excreted in breast milk. Physicians should evaluate the risk‑benefit ratio for each patient and monitor both mother and infant closely if therapy is continued.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Hydroxychloroquine differs from other antimalarials such as chloroquine by having a longer half‑life and a more favorable safety profile in many patients. Compared with biologic immunomodulators for rheumatoid arthritis or lupus, it is an oral small‑molecule option that may be used earlier in therapy, though it may have slower onset of action.

Hydroxychloroquine tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keeping the product in a dry, well‑ventilated area helps maintain its stability throughout its shelf life.

The medication is taken orally, usually with or without food, as directed by a healthcare professional. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed. Consistent timing each day helps maintain stable drug levels.

Serious adverse effects include retinal toxicity that can lead to irreversible vision loss, cardiac complications such as QT prolongation or cardiomyopathy, severe hypoglycemia, and hemolysis in patients with G6PD deficiency. Prompt medical attention is required if any of these symptoms develop.

Patients with known hypersensitivity to hydroxychloroquine or related compounds, those with pre‑existing retinopathy, significant cardiac conduction disorders, or G6PD deficiency should avoid the drug. Additionally, individuals taking medications that markedly prolong the QT interval should be evaluated carefully before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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