Product image of Hydroxychloroquine Sulfate Edest Intas Third Party Sales 2005 (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquine Sulfate Edest Intas Third Party Sales 2005

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquine Sulfate Edest Intas Third Party Sales 2005 (Hydroxychloroquine Sulfate)

Hydroxychloroquine Sulfate, the active ingredient in Hydroxychloroquine Sulfate Edest Intas Third Party Sales 2005, is an antimalarial presented as an oral dosage form for oral use. It is employed in the prevention and treatment of malaria and as an immunomodulatory agent for rheumatoid arthritis and systemic lupus erythematosus.

GNH India supplies Hydroxychloroquine Sulfate Edest Intas Third Party Sales 2005 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Intas Third Party Sales 2005, S.L.

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Indications & Clinical Uses

Hydroxychloroquine Sulfate is used in the antimalarial and antirheumatic therapeutic pathways.

  • Malaria: prevents infection and treats acute episodes by targeting Plasmodium parasites.
  • Rheumatoid arthritis: reduces joint inflammation and disease activity through immune modulation.
  • Systemic lupus erythematosus: decreases disease flares and organ involvement by modulating immune response.

How It Works

  • Hydroxychloroquine Sulfate interferes with parasite heme polymerization within the digestive vacuole of Plasmodium species, leading to toxic heme accumulation. In immune cells, it raises lysosomal pH and inhibits antigen processing, thereby reducing cytokine production and dampening auto‑immune activity, providing both antimalarial efficacy and immunomodulatory effects.

Side Effects

Hydroxychloroquine Sulfate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools.
  • Headache: transient cranial pain.
  • Skin rash: mild erythema or itching.
  • Visual disturbance: blurred vision or difficulty focusing.

Serious or Rare Side Effects

  • Retinal toxicity: irreversible vision loss with prolonged use.
  • Cardiac arrhythmia: QT prolongation and potential torsades de pointes.
  • Severe hypoglycemia: especially in diabetic patients.
  • Hemolytic anemia: in individuals with G6PD deficiency.
  • Neuropsychiatric effects: agitation, depression, or psychosis.

Precautions & Warnings

When prescribing Hydroxychloroquine Sulfate, clinicians should consider several safety precautions.

  • Pregnancy: Category D; use only if benefits outweigh risks.
  • G6PD deficiency: risk of hemolysis; assess before therapy.
  • Retinal monitoring: baseline and periodic eye exams recommended.
  • Cardiac risk: avoid in patients with known QT prolongation or concomitant QT‑prolonging drugs.
  • Drug interactions: review concomitant medications for potential major interactions.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Hydroxychloroquine Sulfate interacts with several medicines that can alter its safety or efficacy.

Major Interactions (Avoid)

  • Azithromycin: combined QT prolongation risk.
  • Quinidine: additive cardiac conduction effects.
  • Digoxin: increased serum levels.
  • Cyclosporine: heightened toxicity risk.
  • Rifampin: reduces hydroxychloroquine concentrations.

Moderate Interactions (Monitor Closely)

  • Antacids (aluminum or magnesium): may decrease absorption.
  • Beta‑blockers: potential additive bradycardia.
  • Insulin or oral hypoglycemics: enhanced hypoglycemic effect.
  • NSAIDs: increased risk of renal impairment.
  • Warfarin: possible alteration of INR.

Frequently Asked Questions

Hydroxychloroquine Sulfate is prescribed for the prevention and treatment of malaria, as well as for managing rheumatoid arthritis and systemic lupus erythematosus by modulating the immune response.

The drug blocks parasite heme polymerization inside Plasmodium organisms, causing toxic heme buildup. In immune cells, it raises lysosomal pH, inhibiting antigen processing and reducing cytokine production, which dampens autoimmune activity.

The appropriate dose of Hydroxychloroquine Sulfate is determined by the prescribing clinician based on the specific indication, patient characteristics, and clinical guidelines. Patients should follow the prescriber’s instructions exactly.

Hydroxychloroquine Sulfate is classified as Pregnancy Category D, indicating potential risk to the fetus. It should be used only when the potential benefits justify the risks. Limited data exist for breastfeeding, so a healthcare professional should evaluate safety.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with chloroquine, hydroxychloroquine has a similar mechanism but a better safety profile and longer half‑life, allowing less frequent dosing. Unlike newer agents such as artemisinin‑based combinations, it is also used for autoimmune diseases, offering dual therapeutic benefits.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture and direct light, and ensure the packaging remains tightly closed until use.

Hydroxychloroquine Sulfate is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. Swallow the dosage form whole with a glass of water.

Serious risks include retinal toxicity that can lead to permanent vision loss, cardiac arrhythmias such as QT prolongation, severe hypoglycemia, and hemolytic anemia in patients with G6PD deficiency. Regular monitoring is essential.

Patients with known hypersensitivity to hydroxychloroquine or related compounds, those with pre‑existing retinal disease, significant cardiac conduction abnormalities, or G6PD deficiency should avoid this medication unless a specialist determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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