Product image of Hydroxychloroquine Sulfate Ipca Produtos Farmaceuticos Unipessoal Lda (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquine Sulfate Ipca Produtos Farmaceuticos Unipessoal Lda

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquine Sulfate Ipca Produtos Farmaceuticos Unipessoal Lda (Hydroxychloroquine Sulfate)

Hydroxychloroquine Sulfate, the active ingredient in Hydroxychloroquine Sulfate Ipca Produtos Farmaceuticos Unipessoal Lda, is an antimalarial presented as an oral tablet for oral use. It is employed to treat malaria, rheumatoid arthritis and systemic lupus erythematosus in adult patients.
GNH India supplies Hydroxychloroquine Sulfate Ipca Produtos Farmaceuticos Unipessoal Lda as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ipca Productos Farmaceuticos Unipessoal Lda

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Indications & Clinical Uses

  • Hydroxychloroquine Sulfate is used across several disease families, primarily infectious and autoimmune disorders.
  • Malaria: reduces parasite replication and clears blood-stage infection.
  • Rheumatoid arthritis: alleviates joint inflammation and slows disease progression.
  • Systemic lupus erythematosus: diminishes systemic immune activity and improves skin and organ manifestations.

How It Works

  • Hydroxychloroquine Sulfate interferes with parasite heme polymerization, leading to toxic heme accumulation within Plasmodium species. In autoimmune conditions it modulates the immune response by inhibiting antigen presentation, reducing cytokine release, and altering lysosomal pH, thereby dampening inflammatory cell activation.

Side Effects

Hydroxychloroquine Sulfate may cause a range of adverse reactions.

Common Side Effects

  • Nausea or upset stomach.
  • Diarrhea or abdominal cramps.
  • Headache.
  • Skin rash or itching.
  • Visual disturbances such as blurred vision.
  • Mild dizziness.

Serious or Rare Side Effects

  • Retinal toxicity leading to vision loss.
  • Cardiac arrhythmias, including QT prolongation.
  • Severe hypoglycaemia, especially in diabetic patients.
  • Hematologic abnormalities such as agranulocytosis.
  • Hepatotoxicity or liver enzyme elevation.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Cardiac monitoring: assess baseline ECG and monitor QT interval.
  • Retinal screening: perform ophthalmologic exam prior to use and annually thereafter.
  • Blood glucose: monitor for hypoglycaemia, especially in patients on antidiabetic agents.
  • Liver and kidney function: evaluate hepatic and renal parameters before and during treatment.
  • Allergy check: avoid in individuals with known hypersensitivity to hydroxychloroquine or related compounds.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Hydroxychloroquine Sulfate can affect, and be affected by, several other medicines.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: decrease absorption of hydroxychloroquine.
  • QT‑prolonging agents (e.g., quinidine, azithromycin): increase risk of cardiac arrhythmias.
  • Insulin or oral hypoglycaemic drugs: potentiate hypoglycaemic effect.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine): raise hydroxychloroquine plasma levels.

Moderate Interactions (Monitor Closely)

  • Digoxin: may increase serum digoxin concentrations.
  • Warfarin: potential alteration of anticoagulant effect.
  • Rifampicin: may reduce hydroxychloroquine exposure.
  • Azathioprine: additive bone‑marrow suppression risk.

Frequently Asked Questions

Hydroxychloroquine Sulfate is indicated for the treatment and prophylaxis of malaria, as well as for managing autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In each case the drug helps control disease activity by targeting the underlying pathogenic mechanisms.

The compound works by inhibiting the polymerization of heme within malaria parasites, causing toxic buildup that kills the organism. In autoimmune disorders it modulates immune function by interfering with antigen presentation, reducing cytokine production, and altering lysosomal pH, which collectively dampens inflammatory responses.

The dosage of Hydroxychloroquine Sulfate is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and other clinical factors. Only a qualified healthcare professional should determine the appropriate regimen.

The safety of Hydroxychloroquine Sulfate in pregnancy and lactation has not been definitively established. Healthcare providers must weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Hydroxychloroquine Sulfate offers a dual mechanism useful for both malaria prophylaxis and autoimmune disease control, distinguishing it from agents that target only one pathway. Compared with chloroquine, it has a more favorable safety profile, especially regarding retinal toxicity, while still providing comparable efficacy in approved indications.

Hydroxychloroquine Sulfate tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date indicated on the packaging.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically advised by a healthcare professional.

Serious adverse events include retinal toxicity that can lead to permanent vision loss, cardiac arrhythmias such as QT prolongation, severe hypoglycaemia, and hematologic disorders like agranulocytosis. Patients should be monitored regularly for these complications, especially when therapy is prolonged.

Hydroxychloroquine Sulfate is contraindicated in individuals with known hypersensitivity to the drug or related compounds, and should be used with caution in patients with pre‑existing retinal disease, significant cardiac conduction abnormalities, or severe hepatic or renal impairment. A thorough medical assessment is required before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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