Product image of Hydroxychloroquine Sulfate Zentiva Pharma (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquine Sulfate Zentiva Pharma

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquine Sulfate Zentiva Pharma (Hydroxychloroquine Sulfate)

Hydroxychloroquine, the active ingredient in Hydroxychloroquine Sulfate Zentiva Pharma, is an antimalarial presented as an oral tablet for systemic use. It is employed in the prevention and treatment of malaria and as a disease‑modifying agent in rheumatoid arthritis and systemic lupus erythematosus.

GNH India supplies Hydroxychloroquine Sulfate Zentiva Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with full regulatory compliance and quality assurance.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Hydroxychloroquine is used across several disease families, primarily infectious and autoimmune disorders.

  • Malaria prophylaxis: prevents infection in individuals traveling to endemic regions.
  • Malaria treatment: clears parasitic infection during acute episodes.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Systemic lupus erythematosus: diminishes systemic inflammation and organ involvement.

How It Works

  • Hydroxychloroquine interferes with parasite heme polymerization by increasing the pH of intracellular vacuoles, which impairs malaria parasite survival. In autoimmune conditions, it modulates immune activity by inhibiting Toll‑like receptor signaling and reducing cytokine production, thereby decreasing inflammation and autoimmunity.

Side Effects

Hydroxychloroquine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: occasional stomach upset.
  • Headache: mild to moderate intensity.
  • Visual changes: blurred vision or difficulty focusing.

Serious or Rare Side Effects

  • Retinopathy: progressive vision loss requiring ophthalmologic monitoring.
  • Cardiomyopathy: heart muscle dysfunction that can lead to arrhythmias.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, several safety considerations should be addressed.

  • Retinal monitoring: schedule baseline and periodic eye exams.
  • Cardiac assessment: evaluate QT interval and cardiac history.
  • Blood glucose control: monitor for hypoglycemia, especially with diabetic medications.
  • Hepatic/renal function: adjust use if significant impairment exists.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Hydroxychloroquine can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce drug absorption.
  • QT‑prolonging agents (e.g., quinidine, azithromycin): increase risk of cardiac arrhythmias.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine): raise hydroxychloroquine plasma levels.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycemics: may potentiate hypoglycemia.
  • Digoxin: can increase serum digoxin concentrations.

Frequently Asked Questions

Hydroxychloroquine Sulfate Zentiva Pharma is prescribed for malaria prophylaxis and treatment, as well as for managing rheumatoid arthritis and systemic lupus erythematosus. In each case, it helps control infection or modulate the immune response to reduce disease activity.

The drug interferes with the malaria parasite’s ability to detoxify heme by raising the pH inside its digestive vacuole, which is lethal to the parasite. In autoimmune diseases, it dampens immune activation by inhibiting Toll‑like receptors and decreasing cytokine release, thereby reducing inflammation.

The dosage is individualized by the prescribing clinician based on the specific indication, patient weight, renal function, and other clinical factors. Healthcare providers determine the appropriate strength and frequency according to current treatment guidelines.

Safety data for hydroxychloroquine in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. Clinicians must weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydroxychloroquine offers a favorable safety profile compared with some older antimalarials and certain disease‑modifying agents, but it may act more slowly than newer biologics for rheumatoid arthritis. Its dual activity against malaria and autoimmune disease makes it a versatile choice when both indications are relevant.

Hydroxychloroquine Sulfate Zentiva Pharma should be stored at or below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining a stable ambient environment helps preserve tablet integrity and potency.

The medication is taken orally, typically with or without food, as directed by the prescriber. Patients should swallow tablets whole with a full glass of water and follow any specific timing instructions provided by their healthcare professional.

The most concerning adverse events include retinal toxicity leading to irreversible vision loss, cardiomyopathy with potential arrhythmias, and severe cutaneous reactions such as Stevens‑Johnson syndrome. Regular monitoring and prompt reporting of symptoms are essential to mitigate these risks.

Patients with known hypersensitivity to hydroxychloroquine or related compounds, those with pre‑existing retinopathy, significant cardiac conduction abnormalities, or severe hepatic or renal impairment should avoid this medication unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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