Product image of Hydroxychloroquinesulfaat Doc (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquinesulfaat Doc

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquinesulfaat Doc (Hydroxychloroquine Sulfate)

Hydroxychloroquine sulfate, the active ingredient in Hydroxychloroquinesulfaat Doc, is an antimalarial presented as an oral tablet for oral use. It treats malaria and is used as a disease‑modifying antirheumatic drug in rheumatoid arthritis and systemic lupus erythematosus.

GNH India supplies Hydroxychloroquinesulfaat Doc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

Hydroxychloroquine sulfate is employed in several infectious and autoimmune disease pathways.

  • Malaria: Reduces parasite replication and clears blood‑stage infection.
  • Rheumatoid arthritis: Decreases joint inflammation and slows disease progression.
  • Systemic lupus erythematosus: Controls disease activity and reduces flare frequency.

How It Works

  • Hydroxychloroquine sulfate accumulates in acidic intracellular compartments, where it interferes with heme polymerization in Plasmodium parasites, leading to toxic heme buildup. In immune cells, it raises endosomal pH, disrupting antigen processing and presentation, and inhibits Toll‑like receptor signaling, thereby reducing cytokine production and modulating the autoimmune response. The combined antimalarial and immunomodulatory actions account for its therapeutic use in both infectious and rheumatic conditions.

Side Effects

Hydroxychloroquine sulfate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools.
  • Skin rash: mild erythematous eruption.

Serious or Rare Side Effects

  • Retinopathy: progressive vision loss requiring ophthalmologic monitoring.
  • Cardiac toxicity: arrhythmias or cardiomyopathy.
  • Severe hypoglycemia: especially in diabetic patients.

Precautions & Warnings

When prescribing hydroxychloroquine sulfate, clinicians should observe several precautionary measures to ensure patient safety.

  • Baseline eye exam: perform ophthalmologic assessment before therapy and annually thereafter.
  • Cardiac monitoring: evaluate ECG and cardiac function in patients with pre‑existing heart disease.
  • Renal impairment: adjust use in severe renal dysfunction.
  • Concomitant QT‑prolonging drugs: avoid or monitor for additive effects.
  • Pregnancy and lactation: assess risk‑benefit ratio before use.
  • Store at ambient temperature: keep below 25 °C in original container, protect from moisture.

Avoid Interactions

Hydroxychloroquine sulfate interacts with several medicines that can alter its efficacy or safety profile.

Major Interactions (Avoid)

  • Azithromycin: combined QT prolongation risk.
  • Amiodarone: additive cardiac conduction effects.
  • Digoxin: increased serum levels.

Moderate Interactions (Monitor Closely)

  • Antacids (aluminum, magnesium): may reduce absorption.
  • CYP2D6 inhibitors (e.g., fluoxetine): may increase plasma concentrations.
  • Warfarin: potential alteration of anticoagulant effect.

Frequently Asked Questions

Hydroxychloroquinesulfaat Doc contains hydroxychloroquine sulfate, which is indicated for the treatment and prophylaxis of malaria, as well as for disease‑modifying therapy in rheumatoid arthritis and systemic lupus erythematosus. In each condition it helps control disease activity, reduce symptoms, and prevent complications when used under medical supervision.

Hydroxychloroquine accumulates in acidic cellular compartments, disrupting the parasite’s heme polymerization pathway, which leads to toxic heme accumulation and parasite death. In immune cells it raises endosomal pH, impairing antigen processing and Toll‑like receptor signaling, thereby decreasing cytokine release and modulating autoimmune responses.

The dosage of hydroxychloroquine sulfate is individualized by the prescribing clinician based on the specific indication, patient weight, renal function, and other clinical factors. Physicians determine the appropriate strength, frequency, and duration of therapy to achieve optimal therapeutic effect while minimizing risk.

Safety data for hydroxychloroquine sulfate in pregnancy and lactation are limited. The drug should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers must evaluate each case and discuss potential risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Hydroxychloroquine is chemically related to chloroquine but generally has a better safety profile, especially regarding retinal toxicity. Compared with biologic disease‑modifying agents, it is an oral small‑molecule option that is less costly and does not require injection, though its efficacy may be lower in severe disease and monitoring for ocular side effects remains essential.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

Hydroxychloroquinesulfaat Doc is administered orally. The tablet should be swallowed whole with a glass of water, preferably with food to reduce gastrointestinal discomfort. Patients should follow the dosing schedule prescribed by their healthcare professional and should not alter the regimen without medical advice.

The most serious adverse events include retinal toxicity (which can lead to irreversible vision loss), cardiac toxicity such as arrhythmias or cardiomyopathy, and severe hypoglycemia, particularly in diabetic patients. Prompt reporting of visual changes, cardiac symptoms, or unexplained low blood sugar is essential for early intervention.

Hydroxychloroquinesulfaat Doc should be avoided in individuals with known hypersensitivity to hydroxychloroquine or related compounds, pre‑existing retinal disease, severe cardiac conduction disorders, or those taking other medications that significantly prolong the QT interval. Patients with uncontrolled severe renal impairment should also be evaluated carefully before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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