Product image of Hydroxychloroquinsulfat Dr. Eberth (Hydroxychloroquine Sulfate) supplied by GNH India

Hydroxychloroquinsulfat Dr. Eberth

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Hydroxychloroquinsulfat Dr. Eberth (Hydroxychloroquine Sulfate)

Hydroxychloroquine sulfate, the active ingredient in Hydroxychloroquinsulfat Dr. Eberth, is an antimalarial presented as an oral tablet for oral use. It is employed in the treatment and management of malaria, rheumatoid arthritis, and systemic lupus erythematosus in adult patients. It is often prescribed by rheumatologists and infectious disease specialists.

GNH India supplies Hydroxychloroquinsulfat Dr. Eberth as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured batches, reliable logistics and support for regulatory documentation across markets.

Manufacturer / TM Owner

Dr. Friedrich Eberth Arzneimittel Gmbh

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Indications & Clinical Uses

Hydroxychloroquine sulfate acts on malaria parasites and modulates immune activity in autoimmune diseases.

  • Malaria: Clears blood‑stage parasites and reduces disease recurrence.
  • Rheumatoid arthritis: Decreases joint inflammation and slows disease progression.
  • Systemic lupus erythematosus: Lowers disease activity and prevents flares.

How It Works

  • Hydroxychloroquine sulfate accumulates in lysosomes, raising intralysosomal pH and inhibiting autophagy. This impairs antigen processing and presentation, thereby modulating T‑cell activation. In malaria parasites, the drug interferes with heme polymerization, leading to toxic heme accumulation and parasite death. Additionally, it reduces cytokine production and stabilizes lysosomal membranes, contributing to its disease‑modifying properties.

Side Effects

Hydroxychloroquine sulfate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: Upset stomach or vomiting.
  • Headache: Mild to moderate cranial pain.
  • Dizziness: Light‑headed sensation.
  • Skin rash: Itchy erythematous eruptions.

Serious or Rare Side Effects

  • Retinopathy: Progressive vision loss that may be irreversible.
  • Cardiomyopathy: Heart muscle dysfunction leading to arrhythmias.
  • Stevens‑Johnson syndrome: Severe skin and mucous membrane reaction.

Precautions & Warnings

When prescribing hydroxychloroquine sulfate, several precautions should be observed to minimise risk.

  • Pregnancy: Use only if potential benefit justifies potential fetal risk.
  • Retinal monitoring: Perform baseline and periodic ophthalmologic examinations.
  • Cardiac assessment: Evaluate QT interval and monitor for arrhythmias in at‑risk patients.
  • Drug interactions: Review concomitant medications that may prolong QT or affect metabolism.
  • Renal/hepatic impairment: Adjust dosage or monitor closely in patients with organ dysfunction.
  • Store at ambient temperature: Keep in original packaging, protect from moisture and light.

Avoid Interactions

Hydroxychloroquine sulfate interacts with several medicines; awareness of the interaction level guides clinical management.

Major Interactions (Avoid)

  • Azithromycin: Combined use may markedly prolong QT interval.
  • Quinine: Additive cardiotoxic effects increase risk of arrhythmia.
  • Amiodarone: Heightened potential for serious cardiac rhythm disturbances.

Moderate Interactions (Monitor Closely)

  • Cimetidine: May increase hydroxychloroquine plasma concentrations.
  • Warfarin: Hydroxychloroquine can enhance anticoagulant effect, requiring INR monitoring.
  • Sulfonylurea antidiabetics: Increased risk of hypoglycaemia; glucose levels should be checked.

Frequently Asked Questions

Hydroxychloroquinsulfat contains hydroxychloroquine sulfate, which is used to treat and prevent malaria, to manage rheumatoid arthritis, and to control disease activity in systemic lupus erythematosus. It works by targeting the malaria parasite and by modulating immune responses in autoimmune conditions.

Hydroxychloroquine sulfate accumulates in acidic cellular compartments, raising their pH and inhibiting lysosomal activity. This disrupts antigen processing, reduces cytokine production, and modulates T‑cell activation. In malaria parasites, it interferes with heme polymerisation, causing toxic heme buildup that kills the parasite.

The appropriate dose of Hydroxychloroquinsulfat is determined by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and any concomitant therapies. Dosage regimens are individualized and should follow the prescriber’s written instructions.

The safety of hydroxychloroquine sulfate in pregnancy and lactation has not been definitively established. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Hydroxychloroquinsulfat, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Hydroxychloroquinsulfat offers both antimalarial activity and immunomodulatory effects, making it useful for malaria prophylaxis and for autoimmune diseases such as rheumatoid arthritis and lupus. Compared with other DMARDs, it has a different safety profile, lacking the bone marrow suppression seen with methotrexate, but it requires monitoring for retinal toxicity and cardiac effects.

Hydroxychloroquinsulfat should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight and excessive heat to maintain stability and potency throughout its shelf life.

Hydroxychloroquinsulfat is administered orally, typically as a tablet that is swallowed with water. The exact timing (e.g., with or without food) should follow the prescribing clinician’s instructions to optimise absorption and minimise gastrointestinal discomfort.

The most serious risks include retinal toxicity that can lead to irreversible vision loss, cardiomyopathy or arrhythmias such as QT prolongation, and severe skin reactions like Stevens‑Johnson syndrome. Regular ophthalmologic examinations and cardiac monitoring are advised for patients on long‑term therapy.

Hydroxychloroquinsulfat is contraindicated in patients with known hypersensitivity to hydroxychloroquine or related compounds. Caution is also advised for individuals with pre‑existing retinal disease, significant cardiac conduction abnormalities, severe hepatic or renal impairment, and those taking other QT‑prolonging medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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