Product image of Hydroxyzine Bluefish (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzine Bluefish

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzine Bluefish (Hydroxyzine Hydrochloride)

Hydroxyzine hydrochloride, the active ingredient in Hydroxyzine Bluefish, is a first‑generation antihistamine presented as an oral tablet for oral administration. It is used to alleviate allergic skin conditions, reduce pruritus, provide anxiolytic effects, facilitate pre‑operative sedation and control nausea in adult patients.

GNH India supplies Hydroxyzine Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is manufactured in the European Union and meets EU pharmacopeial standards. It is distributed under a valid marketing authorization and complies with international quality guidelines.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

  • Hydroxyzine works by blocking H1 histamine receptors, providing relief across several allergic and anxiety‑related conditions.
  • Allergic skin conditions: reduces itching and inflammation associated with allergic dermatitis.
  • Pruritus: alleviates intense itching caused by dermatologic disorders.
  • Anxiety: produces calming effects useful in short‑term management of anxiety.
  • Pre‑operative sedation: induces sedation to facilitate surgical procedures.
  • Nausea: helps control nausea and vomiting in various clinical settings.

How It Works

  • Hydroxyzine hydrochloride acts as a selective antagonist of peripheral H1 histamine receptors, preventing histamine‑induced vasodilation, increased vascular permeability and sensory nerve stimulation. Its additional anticholinergic activity reduces secretions, while central nervous system penetration produces sedative and anxiolytic effects through inhibition of neuronal excitation. The combined actions result in antihistaminic, antiallergic, anti‑emetic and calming properties.

Side Effects

Hydroxyzine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Dry mouth: decreased salivation leading to a sticky sensation.
  • Blurred vision: temporary difficulty focusing.
  • Constipation: reduced bowel movements.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Tachycardia: rapid heart rate that may require medical attention.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Allergic reactions: rash, swelling, or anaphylaxis.
  • Seizures: convulsive episodes in susceptible individuals.
  • Arrhythmias: irregular heart rhythms.

Precautions & Warnings

  • When prescribing hydroxyzine, clinicians should consider several safety precautions.
  • Pregnancy: Category B; use only if benefit outweighs risk.
  • Elderly patients: increased sensitivity to sedative and anticholinergic effects; monitor closely.
  • Driving and machinery: avoid operating vehicles or heavy equipment until individual response is known.
  • Concomitant CNS depressants: assess risk of additive sedation when combined with alcohol, opioids or benzodiazepines.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Hydroxyzine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypotension and additive CNS depression.
  • CNS depressants (benzodiazepines, opioids, barbiturates): may cause profound sedation and respiratory depression.
  • Alcohol: enhances sedative effects and impairs coordination.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs (e.g., atropine, antihistamines): may increase dryness, constipation and urinary retention.
  • Antihypertensive agents: hydroxyzine may potentiate blood pressure‑lowering effects.
  • Tricyclic antidepressants: combined anticholinergic load can intensify side effects.

Frequently Asked Questions

Hydroxyzine Bluefish contains hydroxyzine hydrochloride, a first‑generation antihistamine that is prescribed to treat allergic skin conditions, relieve itching (pruritus), provide short‑term relief of anxiety, serve as a pre‑operative sedative, and help control nausea and vomiting in adult patients.

Hydroxyzine hydrochloride blocks peripheral H1 histamine receptors, preventing the actions of histamine that cause itching, swelling and vasodilation. It also has anticholinergic properties that reduce secretions and penetrates the central nervous system, where it produces sedative and anxiolytic effects by dampening neuronal excitation.

The appropriate dose of Hydroxyzine Bluefish is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

Hydroxyzine is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies the potential risk. Limited data are available for breastfeeding, so a risk‑benefit assessment is required.

To order Hydroxyzine Bluefish, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. The sales team will verify trade or institutional credentials, then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Hydroxyzine is a first‑generation antihistamine, which means it has stronger sedative and anticholinergic effects compared with second‑generation agents such as cetirizine or loratadine. This makes it useful for situations where sedation or anxiolysis is desired, but it may cause more drowsiness and dry‑mouth side effects than newer, non‑sedating antihistamines.

Hydroxyzine Bluefish should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, light and excessive heat. Do not store in the bathroom or near a kitchen sink. Keep out of reach of children.

Hydroxyzine Bluefish is administered orally as a tablet. The patient should swallow the tablet whole with water, unless otherwise directed by the prescriber. It can be taken with or without food, but consistency in administration (with meals or on an empty stomach) helps maintain stable absorption.

Serious risks include rapid heart rate (tachycardia), severe low blood pressure (hypotension), allergic reactions such as rash or anaphylaxis, seizures, and abnormal heart rhythms (arrhythmias). If any of these occur, medical attention should be sought immediately.

Hydroxyzine should be avoided in patients with known hypersensitivity to hydroxyzine or other first‑generation antihistamines, in individuals with severe hepatic impairment, and in those taking monoamine oxidase inhibitors (MAOIs) within the past 14 days. Caution is also advised for the elderly, patients with glaucoma, urinary retention, or prostatic hypertrophy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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