Product image of Hydroxyzine Hydrochloride Rudipharm (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzine Hydrochloride Rudipharm

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzine Hydrochloride Rudipharm (Hydroxyzine Hydrochloride)

Hydroxyzine Hydrochloride, the active ingredient in Hydroxyzine Hydrochloride Rudipharm, is a first‑generation antihistamine presented as an oral tablet for oral use. It is used to treat allergic rhinitis, pruritus, anxiety and provides sedation in appropriate clinical settings.

GNH India supplies Hydroxyzine Hydrochloride Rudipharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rudipharm Limited

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Indications & Clinical Uses

  • Hydroxyzine Hydrochloride acts on histamine H1 receptors to alleviate allergic and related conditions.
  • Allergic rhinitis: reduces nasal congestion, itching and sneezing.
  • Pruritus: relieves skin itching associated with allergic dermatoses.
  • Anxiety: provides a calming effect in patients with mild anxiety.
  • Sedation: induces sleepiness useful for pre‑procedural calming.

How It Works

  • Hydroxyzine Hydrochloride selectively antagonizes peripheral histamine H1 receptors, preventing histamine‑mediated vasodilation, increased vascular permeability, and sensory nerve stimulation. By blocking these receptors, it diminishes the classic symptoms of allergic reactions and exerts central nervous system depressant effects that contribute to its anxiolytic and sedative properties.

Side Effects

Hydroxyzine Hydrochloride may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness or sedation
  • Dry mouth
  • Blurred vision
  • Constipation
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Tachycardia or arrhythmia
  • Severe hypotension
  • Anaphylactic reactions
  • Hepatic injury
  • Seizures
  • Agranulocytosis

Precautions & Warnings

  • When prescribing Hydroxyzine Hydrochloride, consider the following safety measures.
  • Assess hepatic function: monitor liver enzymes in patients with known liver disease.
  • Avoid alcohol: concurrent use may intensify CNS depression.
  • Use caution in elderly: increased susceptibility to anticholinergic effects.
  • Monitor QT interval: may prolong in patients with cardiac risk factors.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Hydroxyzine Hydrochloride can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression.
  • Opioids: enhanced sedation and risk of respiratory depression.
  • Anticholinergic drugs: increased anticholinergic burden.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may increase drowsiness.
  • CYP3A4 inhibitors (e.g., ketoconazole): can raise hydroxyzine plasma levels.

Frequently Asked Questions

Hydroxyzine Hydrochloride Rudipharm is indicated for the relief of symptoms associated with allergic rhinitis, for the treatment of pruritus caused by allergic skin conditions, for mild anxiety, and as a sedative in pre‑procedural or short‑term therapeutic settings.

Hydroxyzine works by selectively blocking peripheral histamine H1 receptors, which prevents histamine‑induced vasodilation, increased vascular permeability, and nerve stimulation. This blockade reduces allergic symptoms and also produces central nervous system depressant effects that contribute to its anxiolytic and sedative actions.

The appropriate dose of Hydroxyzine Hydrochloride Rudipharm is determined by the prescribing healthcare professional based on the patient’s age, condition being treated, and overall health status. Dosage adjustments may be required for special populations such as the elderly or those with hepatic impairment.

The safety of Hydroxyzine Hydrochloride during pregnancy or lactation has not been definitively established. Healthcare providers should weigh the potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing patients.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Hydroxyzine is a first‑generation antihistamine, distinguished by its strong sedative and anxiolytic properties, which are less pronounced in second‑generation agents. While it provides effective relief for allergic symptoms, its anticholinergic and CNS‑depressant effects may limit use in patients who require alertness or have contraindications to sedation.

Hydroxyzine Hydrochloride Rudipharm should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat and direct sunlight to maintain potency and stability.

The medication is taken orally, typically as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events, though rare, include severe hypotension, tachyarrhythmias, anaphylactic reactions, hepatic injury, seizures, and agranulocytosis. Patients should seek immediate medical attention if they experience symptoms such as rapid heartbeat, fainting, severe rash, difficulty breathing, or unexplained bruising.

Hydroxyzine should be avoided in individuals with known hypersensitivity to the drug, those with severe hepatic impairment, patients taking potent CYP3A4 inhibitors without medical supervision, and anyone for whom sedation could pose a safety risk, such as operators of heavy machinery or drivers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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