Product image of Hydroxyzine Orifarm (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzine Orifarm

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzine Orifarm (Hydroxyzine Hydrochloride)

Hydroxyzine hydrochloride, the active ingredient in Hydroxyzine Orifarm, is a first‑generation antihistamine presented as an oral tablet for oral use. It is employed to alleviate allergic skin conditions, relieve itching, reduce anxiety, provide sedation, and control nausea in adult patients.

GNH India supplies Hydroxyzine Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

  • Hydroxyzine Orifarm is a first‑generation antihistamine that acts on histamine H1 receptors to manage several conditions.
  • Allergic skin conditions: reduces inflammation and itching associated with urticaria and dermatitis.
  • Pruritus: provides relief from generalized itching not responsive to other therapies.
  • Anxiety: produces a calming effect useful in short‑term management of anxiety.
  • Sedation: induces sleepiness for procedural sedation or insomnia.
  • Nausea: helps control nausea and vomiting related to various causes.

How It Works

  • Hydroxyzine hydrochloride selectively blocks histamine H1 receptors in peripheral tissues and the central nervous system, preventing histamine‑mediated responses. Its antagonism also produces anticholinergic activity and central sedative effects by inhibiting neuronal excitation, which together alleviate allergic symptoms, itching, anxiety, and nausea.

Side Effects

Hydroxyzine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation leading to a parched sensation.
  • Dizziness: light‑headedness or unsteady feeling.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that may require medical attention.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Stevens‑Johnson syndrome: rare skin reaction with blistering and detachment.

Precautions & Warnings

  • Before using Hydroxyzine Orifarm, consider the following safety measures.
  • Elderly patients: increased risk of sedation and falls.
  • Driving or operating machinery: avoid until the effect on alertness is known.
  • Concomitant CNS depressants: may enhance drowsiness and respiratory depression.
  • Pregnancy: safety not established; use only if clearly needed.
  • Renal or hepatic impairment: dose may require adjustment.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Hydroxyzine can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • CNS depressants: additive sedation and respiratory depression.
  • Alcohol: enhances drowsiness and impairment.
  • QT‑prolonging agents: increased risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors: may raise hydroxyzine plasma levels.
  • Antihypertensives: potential additive blood‑pressure lowering effect.

Frequently Asked Questions

Hydroxyzine Orifarm is a prescription antihistamine indicated for the relief of allergic skin conditions such as urticaria, the control of itching (pruritus), short‑term management of anxiety, procedural sedation, and the treatment of nausea and vomiting associated with various causes.

Hydroxyzine hydrochloride works by selectively blocking histamine H1 receptors in the body and brain, which prevents histamine‑mediated allergic reactions. Its additional anticholinergic and central sedative actions contribute to its effectiveness in reducing itching, anxiety, and nausea.

The appropriate dose of Hydroxyzine Orifarm is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, severity of symptoms, and any relevant medical history. Dosage may be adjusted for renal or hepatic impairment.

Safety of Hydroxyzine Orifarm in pregnancy and lactation has not been conclusively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified prescriber.

To order Hydroxyzine Orifarm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydroxyzine is a first‑generation antihistamine, distinguished by its pronounced sedative and anticholinergic effects compared with second‑generation agents that cause less drowsiness. It is often chosen when sedation or anxiolysis is desired, whereas newer antihistamines are preferred for daytime allergy relief without significant sedation.

Hydroxyzine Orifarm should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Hydroxyzine Orifarm is administered orally, typically as a tablet that is swallowed whole with water. The exact administration schedule and any special instructions are provided by the prescribing clinician.

Serious risks include cardiac arrhythmias, severe hypotension, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience irregular heartbeat, fainting, or widespread skin blistering.

Hydroxyzine Orifarm should be avoided in individuals with known hypersensitivity to hydroxyzine or other first‑generation antihistamines, in patients with prolonged QT interval, and in those taking other medications that significantly depress the central nervous system unless closely supervised.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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