Hydroxyzine Renaudin (Hydroxyzine Hydrochloride)

Hydroxyzine works by selectively blocking peripheral H1 histamine receptors, which prevents histamine‑mediated vasodilation, increased vascular permeability and sensory nerve activation. Its additional anticholinergic, anti‑serotonergic and anti‑adrenergic actions contribute to its sedative, anxiolytic and anti‑emetic properties.

The dosage of Hydroxyzine Renaudin is determined by the prescribing clinician based on the patient’s condition, age, weight, renal and hepatic function, and the route of administration. The prescriber selects the appropriate concentration and volume for intramuscular or intravenous injection.

Safety data for hydroxyzine during pregnancy and lactation are limited. It is classified as pregnancy category unknown, and because the drug is excreted in breast milk, it should be used only if the potential benefit justifies the potential risk to the fetus or infant. Consultation with a specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including cold‑chain if needed) and assists with import documentation.

Compared with first‑generation oral antihistamines, Hydroxyzine Renaudin offers rapid onset via injection and higher plasma concentrations, making it suitable for acute settings. Unlike some antihistamines that lack sedative effects, hydroxyzine provides both antihistaminic and anxiolytic actions, but it may cause more pronounced drowsiness. It is not interchangeable with second‑generation antihistamines that have reduced central nervous system penetration.

Store at 2‑8 °C: keep the vial refrigerated, protect from light, and do not freeze or shake the solution. If temporary exposure to higher temperatures occurs, return the product to controlled conditions promptly and inspect for any changes before use.

Hydroxyzine Renaudin is supplied as a sterile injectable solution for intramuscular or intravenous injection. The appropriate dose is drawn into a syringe under aseptic technique and administered by a qualified healthcare professional, observing standard infection‑control practices and monitoring the patient for any immediate reactions.

Serious adverse reactions, although rare, include cardiac arrhythmias, severe hypotension, anaphylactic shock, hepatotoxicity and seizures. Patients should be monitored for signs of cardiovascular instability, respiratory depression, or allergic response, especially when combined with other central nervous system depressants.

Contra‑indications include patients with known hypersensitivity to hydroxyzine or any component of the formulation, and individuals with severe hepatic impairment where the drug may accumulate. Caution is advised in the elderly, patients taking other sedatives, and those with a history of QT prolongation or cardiac conduction disorders.