Product image of Hydroxyzine Zentiva (Hydroxyzine Dihydrochloride) supplied by GNH India

Hydroxyzine Zentiva

Active Ingredient:
Hydroxyzine Dihydrochloride
Origin:
EU

Hydroxyzine Zentiva (Hydroxyzine Dihydrochloride)

Hydroxyzine, the active ingredient in Hydroxyzine Zentiva, is an antihistamine presented as an oral tablet for systemic use. It blocks peripheral H1 receptors and is employed to relieve allergic rhinitis, control pruritus, reduce anxiety, and provide pre‑operative sedation in both adult and pediatric patients as directed by a healthcare professional.

GNH India supplies Hydroxyzine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides batch‑tested products with full documentation for regulatory review.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

  • Hydroxyzine is an antihistamine that acts on peripheral H1 receptors to manage several allergic and related conditions.
  • Allergic rhinitis: reduces nasal congestion, sneezing and itching associated with seasonal or perennial allergies.
  • Pruritus: alleviates itching caused by dermatologic disorders such as urticaria.
  • Anxiety: provides short‑term relief of anxiety symptoms in adults.
  • Pre‑operative sedation: produces calming effect before surgical or diagnostic procedures.
  • Nausea: helps control nausea and vomiting in certain clinical settings.

How It Works

  • Hydroxyzine selectively antagonizes peripheral histamine H1 receptors, preventing histamine‑mediated vasodilation, increased vascular permeability, and sensory nerve activation. Its additional anticholinergic activity contributes to drying of secretions, while central nervous system penetration produces sedative and anxiolytic effects through inhibition of neuronal excitability.

Side Effects

Hydroxyzine may cause a range of adverse reactions. Monitoring for side effects is recommended, especially during dose titration.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Blurred vision

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Severe hypotension
  • Stevens‑Johnson syndrome

Precautions & Warnings

  • Hydroxyzine requires careful use in specific populations and clinical situations.
  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Breastfeeding: unknown excretion; consider alternatives.
  • Elderly: increased sensitivity to sedation and anticholinergic effects.
  • Concomitant CNS depressants: may enhance drowsiness and respiratory depression.
  • Renal or hepatic impairment: dose adjustment may be necessary.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Hydroxyzine can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of severe hypotension.
  • CNS depressants (benzodiazepines, opioids): additive sedation and respiratory depression.
  • Anticholinergic agents: increased anticholinergic burden.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance drowsiness.
  • CYP3A4 inhibitors (e.g., ketoconazole): may raise hydroxyzine plasma levels.

Frequently Asked Questions

Hydroxyzine Zentiva is prescribed to treat allergic rhinitis, relieve itching (pruritus) from skin conditions, provide short‑term relief of anxiety, and act as a sedative before surgical or diagnostic procedures. It may also be used to control nausea in certain clinical contexts, always according to a healthcare professional’s direction.

Hydroxyzine works by selectively blocking peripheral histamine H1 receptors, which reduces the effects of histamine such as itching, swelling, and vasodilation. Its anticholinergic properties dry secretions, and its ability to cross the blood‑brain barrier adds sedative and anxiolytic actions by dampening neuronal excitability.

The appropriate dose of Hydroxyzine Zentiva is determined by the prescribing clinician based on the patient’s age, weight, medical condition, and response to therapy. Dosage may differ for allergic symptoms, anxiety, or pre‑operative sedation, and should never be adjusted without professional guidance.

Safety data for hydroxyzine in pregnancy are limited, and the drug is generally avoided unless the potential benefit justifies the risk. Information on excretion into breast milk is also insufficient, so clinicians usually recommend alternative treatments for nursing mothers.

To request Hydroxyzine Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Hydroxyzine differs from many second‑generation antihistamines by having pronounced sedative and anxiolytic properties due to its central nervous system penetration. While it offers effective relief of itching and allergic symptoms, its anticholinergic and sedative effects may be stronger, making it suitable when sedation is desired but less ideal for patients needing to avoid drowsiness.

Hydroxyzine Zentiva tablets should be stored at ambient temperature below 25 °C. Keep them in the original packaging to protect from moisture and light, and store out of reach of children. Do not refrigerate or freeze the product.

Hydroxyzine Zentiva is taken orally, usually as a tablet swallowed with a glass of water. The exact timing—such as with or without food—depends on the prescriber’s instructions and the specific indication being treated.

Serious risks, though uncommon, include cardiac arrhythmias, severe hypotension, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience palpitations, fainting, a rapid drop in blood pressure, or widespread rash with blistering.

Hydroxyzine Zentiva is contraindicated in individuals with known hypersensitivity to hydroxyzine or any component of the formulation. Caution is advised for patients with severe cardiac disease, uncontrolled glaucoma, or those taking other CNS depressants. Pregnant or breastfeeding women should only use it if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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