Product image of Hydroxyzinhydrochlorid Eql Pharma (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzinhydrochlorid Eql Pharma

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzinhydrochlorid Eql Pharma (Hydroxyzine Hydrochloride)

Hydroxyzine Hydrochloride, the active ingredient in Hydroxyzinhydrochlorid, is an antihistamine presented as an oral formulation for systemic use. It is employed to relieve allergic skin reactions, itching, anxiety, sedation and nausea in adult patients and is marketed across European Union markets.

GNH India supplies Hydroxyzinhydrochlorid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with capabilities for bulk manufacturing, quality assurance and regulatory support. The company adheres to EU GMP standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Eql Pharma Ab

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Indications & Clinical Uses

  • Hydroxyzine Hydrochloride acts on peripheral H1 histamine receptors to alleviate symptoms in several allergic and related conditions.
  • Allergic skin conditions: reduces itching, redness and rash associated with histamine release.
  • Pruritus: provides relief from chronic and acute itching.
  • Anxiety: produces calming effects that help manage mild anxiety.
  • Sedation: induces sleepiness useful for short‑term insomnia.
  • Nausea: helps control nausea and vomiting related to motion or medication.

How It Works

  • Hydroxyzine Hydrochloride selectively blocks peripheral H1 histamine receptors, preventing histamine‑mediated vasodilation, increased vascular permeability, and sensory nerve activation. Its additional anticholinergic activity contributes to sedation and anti‑emetic effects, while central nervous system penetration adds anxiolytic properties.

Side Effects

Hydroxyzine Hydrochloride may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness or sedation
  • Dry mouth
  • Blurred vision
  • Constipation
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Cardiac arrhythmias (including QT prolongation)
  • Severe hypotension
  • Seizures
  • Anaphylactic or severe allergic reactions
  • Hepatic dysfunction
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

Hydroxyzine Hydrochloride requires careful use in certain populations and situations.

  • Dose adjustment in renal impairment: reduce dose as advised by prescriber.
  • Avoid use with alcohol: may enhance sedation and respiratory depression.
  • Caution in elderly: increased sensitivity to anticholinergic effects.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Drug interactions: review concomitant medications for CNS depressants.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Hydroxyzine Hydrochloride can interact with several drug classes, necessitating monitoring or avoidance.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, opioids): additive sedation and respiratory depression.
  • Monoamine oxidase inhibitors: risk of severe hypotension.
  • Anticholinergic agents: increased anticholinergic burden.
  • QT‑prolonging drugs: potential cardiac arrhythmias.

Moderate Interactions (Monitor Closely):\n- Alcohol: enhances sedative effect.

  • Antihypertensives: may increase hypotensive effect.
  • Other antihistamines: additive anticholinergic effects.

Frequently Asked Questions

Hydroxyzinhydrochlorid contains hydroxyzine hydrochloride, an antihistamine that is prescribed to treat allergic skin reactions, chronic itching (pruritus), mild anxiety, short‑term insomnia, and nausea or vomiting associated with motion or certain medications.

Hydroxyzine hydrochloride works by selectively blocking peripheral H1 histamine receptors, which prevents histamine‑induced itching, swelling and vasodilation. Its anticholinergic and central nervous system activity also contributes to sedation, anxiolysis and anti‑emetic effects.

The appropriate dose of Hydroxyzinhydrochlorid is determined by the prescribing clinician based on the patient’s age, weight, medical condition and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly.

Safety data for hydroxyzine hydrochloride in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order Hydroxyzinhydrochlorid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydroxyzine hydrochloride offers both antihistamine and sedative properties, making it useful for conditions where itching and anxiety coexist. Compared with non‑sedating antihistamines such as cetirizine, hydroxyzine provides stronger central nervous system effects, which can be advantageous for short‑term insomnia but may limit its use in patients who need to remain alert.

Hydroxyzinhydrochlorid should be stored at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight and sources of heat to maintain its stability and potency.

Hydroxyzinhydrochlorid is administered orally, typically as tablets or oral solution, and should be taken with or without food as directed by the prescriber. Swallow tablets whole with water; do not crush or chew unless the formulation specifically allows it.

Serious risks include severe allergic reactions (anaphylaxis), cardiac arrhythmias such as QT prolongation, profound hypotension, seizures, and rare blood disorders like agranulocytosis. Patients should seek immediate medical attention if they experience symptoms such as rash, difficulty breathing, irregular heartbeat, fainting or unexplained fever.

Hydroxyzinhydrochlorid is contraindicated in individuals with known hypersensitivity to hydroxyzine or any component of the formulation, and in patients taking monoamine oxidase inhibitors within the past 14 days. Caution is also advised for those with severe liver disease, glaucoma, or urinary retention.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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