Product image of Hydroxyzinum Adamed (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzinum Adamed

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzinum Adamed (Hydroxyzine Hydrochloride)

Hydroxyzine Hydrochloride, the active ingredient in Hydroxyzinum Adamed, is a first‑generation antihistamine presented as an oral tablet for oral use. It treats allergic skin conditions, anxiety, and provides sedation before or after surgery in adult patients.

GNH India supplies Hydroxyzinum Adamed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

  • Hydroxyzinum Adamed, a first‑generation antihistamine, acts on peripheral H1 receptors to relieve allergic and related conditions.
  • Urticaria and pruritus: reduces itching and rash associated with allergic skin reactions.
  • Anxiety and tension: alleviates symptoms of anxiety in adult patients.
  • Surgical sedation: provides pre‑operative or post‑operative calming effect.
  • Nausea and vomiting: helps control nausea in various clinical settings.

How It Works

  • Hydroxyzine hydrochloride selectively blocks peripheral H1 histamine receptors, preventing histamine‑mediated vasodilation, increased vascular permeability, and sensory nerve activation. The antagonism also produces anticholinergic effects and central nervous system depression, contributing to its anxiolytic, anti‑emetic, and sedative properties.

Side Effects

Hydroxyzinum Adamed may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Severe hypotension
  • Anaphylactic reaction
  • Seizures
  • Hepatic dysfunction
  • QT interval prolongation

Precautions & Warnings

  • Before prescribing Hydroxyzinum Adamed, consider the following precautions to ensure safe use.
  • Pregnancy: Category B – use only if potential benefit justifies the potential risk to the fetus.
  • Elderly patients: increased sensitivity to sedative and anticholinergic effects; monitor closely.
  • Renal impairment: may require dose adjustment; assess renal function prior to use.
  • Concomitant CNS depressants: risk of enhanced sedation and respiratory depression; avoid or use with caution.
  • Alcohol consumption: may potentiate drowsiness and impair coordination; advise patients to limit intake.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Hydroxyzinum Adamed can interact with other medicines; notable interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypotension and serotonin syndrome.
  • CNS depressants (e.g., benzodiazepines, opioids): may cause profound sedation and respiratory depression.
  • Anticholinergic drugs: additive anticholinergic effects leading to confusion, urinary retention, or severe constipation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: hydroxyzine may enhance hypotensive effect.
  • Other anticholinergic agents: increased dry mouth, constipation, and blurred vision.
  • Alcohol: combined use can increase drowsiness and impair psychomotor performance.

Frequently Asked Questions

Hydroxyzinum Adamed is prescribed for allergic skin reactions such as urticaria and pruritus, for anxiety and tension relief, for pre‑ or post‑operative sedation, and for control of nausea and vomiting.

Hydroxyzine hydrochloride works by selectively blocking peripheral H1 histamine receptors, which prevents histamine‑induced itching, vasodilation and increased vascular permeability. The drug also has anticholinergic activity and depresses central nervous system activity, providing anxiolytic, anti‑emetic and sedative effects.

The dosage of Hydroxyzinum Adamed is determined by the prescribing clinician based on the patient’s age, condition, and response. The prescriber will select the appropriate strength and frequency according to current clinical guidelines.

Hydroxyzinum Adamed is classified as pregnancy category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It should be used only if the potential benefit outweighs any possible risk, and breastfeeding mothers should consult a healthcare professional before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with second‑generation antihistamines, hydroxyzine provides stronger sedative and anxiolytic effects but is more likely to cause anticholinergic side effects. It is often chosen when sedation or anxiety relief is desired in addition to antihistamine activity.

Store Hydroxyzinum Adamed at room temperature below 25 °C, in the original packaging, and protect it from moisture and direct sunlight. Do not refrigerate or freeze the product.

Hydroxyzinum Adamed is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless instructed otherwise.

Serious adverse reactions can include cardiac arrhythmias, severe hypotension, anaphylactic shock, seizures, hepatic dysfunction, and QT‑interval prolongation. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to hydroxyzine or other first‑generation antihistamines, patients with severe hepatic impairment, and those taking contraindicated medications such as MAO inhibitors should not use Hydroxyzinum Adamed unless specifically advised by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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