Product image of Hydroxyzinum Hasco (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzinum Hasco

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzinum Hasco (Hydroxyzine Hydrochloride)

Hydroxyzine hydrochloride, the active ingredient in Hydroxyzinum Hasco, is an antihistamine presented as a tablet for oral use. It treats allergic dermatitis, pruritus, anxiety, provides sedation before surgery, and helps control nausea and vomiting.

GNH India supplies Hydroxyzinum Hasco as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

  • Hydroxyzine hydrochloride is used to manage conditions related to histamine‑mediated reactions and anxiety.
  • Allergic dermatitis: reduces itching and inflammation associated with allergic skin reactions.
  • Pruritus: relieves intense itching of various origins.
  • Anxiety: provides short‑term anxiolytic effect in acute stress situations.
  • Sedation before surgery: produces calming sedation for pre‑operative preparation.
  • Nausea and vomiting: helps control postoperative or chemotherapy‑induced nausea and vomiting.

How It Works

  • Hydroxyzine hydrochloride acts as a selective antagonist of peripheral and central histamine H1 receptors. By blocking H1‑mediated signaling, it diminishes the vascular permeability and sensory nerve activation that cause itching and allergic inflammation. Its anticholinergic activity contributes to sedation and anti‑emetic effects, while central H1 blockade also produces anxiolytic properties.

Side Effects

Hydroxyzine may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

  • Drowsiness or sedation
  • Dry mouth
  • Blurred vision
  • Constipation
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Severe hypotension
  • Seizures
  • Anaphylactic or severe allergic reactions
  • Hepatic dysfunction
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

  • Before prescribing hydroxyzine, clinicians should consider several safety aspects.
  • Pregnancy: Category B1 – use only if the potential benefit justifies the potential risk to the fetus.
  • Driving: May cause drowsiness; advise patients to avoid operating machinery.
  • Concomitant CNS depressants: Increased risk of profound sedation.
  • Elderly: Heightened sensitivity; start at the lowest effective dose.
  • Renal/hepatic impairment: Dose adjustment may be required.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Hydroxyzine can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression.
  • Opioids: enhanced sedation and respiratory depression.
  • CNS depressants (benzodiazepines, barbiturates): risk of profound sedation.
  • Anticholinergic drugs: increased anticholinergic burden.
  • QT‑prolonging agents: potential for cardiac arrhythmia.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise hydroxyzine plasma levels.

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce effectiveness.
  • Antihypertensives: possible additive hypotensive effect.
  • Other anticholinergic agents: may worsen dry mouth and constipation.
  • MAO inhibitors: potential for additive central effects.

Frequently Asked Questions

Hydroxyzinum Hasco contains hydroxyzine hydrochloride and is indicated for allergic dermatitis, pruritus, short‑term anxiety, pre‑operative sedation, and the control of nausea and vomiting associated with surgery or chemotherapy.

Hydroxyzine hydrochloride blocks histamine H1 receptors in peripheral tissues and the central nervous system. This antagonism reduces allergic inflammation, itching, and vasodilation, while its anticholinergic and central H1‑blocking actions produce sedation, anxiolysis, and anti‑emetic effects.

The dosage of Hydroxyzinum Hasco is determined by the prescribing clinician based on the patient’s age, condition, and response. The prescriber will set the appropriate strength, frequency, and duration according to clinical guidelines.

Hydroxyzine hydrochloride is classified as pregnancy category B1, indicating that animal studies have not shown risk but there are limited human data. It should be used only if the potential benefit outweighs any possible risk. Caution is also advised during breastfeeding, and a healthcare professional should be consulted.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Hydroxyzine offers both antihistaminic and sedative properties, making it useful for conditions where itching and anxiety coexist. Compared with non‑sedating antihistamines such as cetirizine, hydroxyzine provides stronger sedation and anxiolysis, but may cause more drowsiness and anticholinergic effects.

Hydroxyzinum Hasco should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. This helps maintain tablet integrity and potency throughout its shelf life.

Hydroxyzinum Hasco is taken orally as a tablet. It should be swallowed whole with water, unless the prescriber advises otherwise. The exact timing (e.g., with or without food) depends on the individual treatment plan.

Serious adverse reactions, although rare, include cardiac arrhythmias, severe hypotension, seizures, anaphylactic reactions, hepatic dysfunction, and blood dyscrasias such as agranulocytosis. Patients should seek immediate medical attention if they experience any of these symptoms.

Hydroxyzinum Hasco is contraindicated in patients with known hypersensitivity to hydroxyzine or any component of the formulation, and in individuals with severe QT prolongation or certain cardiac conduction disorders. Caution is also advised for patients with uncontrolled glaucoma, severe urinary retention, or significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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