Product image of Hydroxyzinum Polfarmex (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzinum Polfarmex

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzinum Polfarmex (Hydroxyzine Hydrochloride)

Hydroxyzine Hydrochloride, the active ingredient in Hydroxyzinum Polfarmex, is a first‑generation antihistamine presented as an oral dosage form for oral use. It is employed to relieve allergic skin reactions, manage anxiety and tension, provide sedation before or after surgical procedures, and control nausea and vomiting in appropriate patients.

GNH India supplies Hydroxyzinum Polfarmex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable global logistics through established distribution networks.

Manufacturer / TM Owner

Polfarmex S.A.

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Indications & Clinical Uses

Hydroxyzine Hydrochloride is used to treat conditions mediated by histamine release and central nervous system excitation.

  • Allergic dermatoses and pruritus: reduces itching and skin inflammation associated with allergic reactions.
  • Anxiety and tension relief: provides a calming effect and reduces subjective anxiety in patients.
  • Sedation for surgical procedures: induces pre‑operative or post‑operative sedation and anxiolysis.
  • Nausea and vomiting: helps control nausea and vomiting related to various causes.

How It Works

  • Hydroxyzine Hydrochloride acts as a selective antagonist of peripheral and central histamine H1 receptors, blocking the action of endogenous histamine. By inhibiting H1‑mediated signaling, it reduces vasodilation, increased vascular permeability and sensory nerve activation that cause itching and allergic symptoms. The drug also penetrates the blood‑brain barrier, producing anticholinergic and sedative effects through central H1 blockade and additional modulation of serotonergic pathways.

Side Effects

Hydroxyzine Hydrochloride may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Dry mouth: decreased salivation causing a dry sensation.
  • Dizziness: light‑headed feeling, especially on standing.
  • Blurred vision: temporary visual disturbances.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythm that may require medical attention.
  • Severe allergic reaction: rash, swelling, or breathing difficulty indicating possible anaphylaxis.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Seizures: convulsive episodes in susceptible individuals.

Precautions & Warnings

When prescribing Hydroxyzine Hydrochloride, clinicians should consider several precautionary measures to ensure safe use.

  • Assess renal and hepatic function: adjust use in patients with significant impairment.
  • Avoid concomitant CNS depressants: increased sedation risk when combined with alcohol or opioids.
  • Monitor elderly patients: higher susceptibility to drowsiness, falls and anticholinergic effects.
  • Caution in pregnancy: limited data; use only if potential benefit outweighs risk.
  • Contraindicated in hypersensitivity: discontinue if allergic reaction occurs.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Hydroxyzine Hydrochloride can interact with other medicines, altering its effects or increasing adverse reactions.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypotension and sedation.
  • CNS depressants (benzodiazepines, opioids): additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: enhanced anticholinergic burden leading to dry mouth, constipation, urinary retention.
  • QT‑prolonging drugs (e.g., quinidine, erythromycin): may increase risk of cardiac arrhythmias.
  • Alcohol: potentiates drowsiness and impairment.

Frequently Asked Questions

Hydroxyzinum Polfarmex contains hydroxyzine hydrochloride, which is indicated for relief of itching associated with allergic skin conditions, reduction of anxiety and tension, provision of sedation before or after surgical procedures, and control of nausea and vomiting in appropriate patients.

Hydroxyzine hydrochloride blocks peripheral and central histamine H1 receptors, preventing histamine‑mediated allergic responses. Its ability to cross the blood‑brain barrier also produces anticholinergic and sedative effects, contributing to anxiety relief and pre‑operative sedation.

The specific dose of Hydroxyzinum Polfarmex is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Only a qualified health professional should set the dosing regimen.

Safety data for hydroxyzine hydrochloride during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with second‑generation antihistamines such as cetirizine, hydroxyzine provides stronger sedative and anxiolytic effects due to its central H1 blockade and anticholinergic activity. However, it may cause more drowsiness and anticholinergic side effects, making it less suitable for patients who need to remain fully alert.

Hydroxyzinum Polfarmex should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The medication is administered orally. Patients should swallow the tablet or capsule whole with water, unless the prescribing information specifies an alternative method such as dispersing a tablet in a small amount of liquid.

Serious risks include cardiac arrhythmias, severe allergic reactions (anaphylaxis), hepatic dysfunction, and seizures. Any signs of these conditions—such as irregular heartbeat, rash with swelling, yellowing of the skin or eyes, or convulsions—require immediate medical attention.

Hydroxyzinum Polfarmex is contraindicated in individuals with known hypersensitivity to hydroxyzine or any of its excipients. Caution is also advised for patients with significant hepatic or renal impairment, uncontrolled narrow‑angle glaucoma, and those taking interacting CNS depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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