Product image of Hydroxyzinum Vp (Hydroxyzine Hydrochloride) supplied by GNH India

Hydroxyzinum Vp

Active Ingredient:
Hydroxyzine Hydrochloride
Origin:
EU

Hydroxyzinum Vp (Hydroxyzine Hydrochloride)

Hydroxyzine hydrochloride, the active ingredient in Hydroxyzinum Vp, is an antihistamine presented as an oral dosage form for systemic use. It is employed to relieve allergic skin reactions, reduce pruritus, provide anxiolytic effects, aid pre‑operative sedation, and control nausea and vomiting in adult patients.

GNH India supplies Hydroxyzinum Vp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with European Union regulatory requirements and is manufactured under GMP conditions. It is distributed through GNH India's global logistics network to ensure timely delivery.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

Hydroxyzine hydrochloride is an H1‑antihistamine used to manage conditions related to allergic and anxiety pathways.

  • Allergic skin reactions: reduces histamine‑mediated itching and inflammation.
  • Pruritus: provides relief from chronic itching associated with dermatologic disorders.
  • Anxiety: produces calming effects useful in short‑term management of anxiety.
  • Pre‑operative sedation: facilitates anxiolysis and sedation before surgical procedures.
  • Nausea and vomiting: helps control postoperative or medication‑induced emesis.

How It Works

  • Hydroxyzine hydrochloride acts as a selective antagonist at peripheral H1 histamine receptors, blocking the actions of endogenous histamine that cause vasodilation, increased vascular permeability, and sensory nerve stimulation. Its additional anticholinergic activity contributes to sedation, while central nervous system effects arise from modest inhibition of serotonergic and dopaminergic pathways, producing anxiolytic and antiemetic properties.

Side Effects

Hydroxyzine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Dry mouth: decreased salivation leading to a sticky sensation.
  • Blurred vision: temporary difficulty focusing.
  • Constipation: reduced bowel motility.

Serious or Rare Side Effects

  • Cardiac arrhythmias: irregular heart rhythms, especially in predisposed patients.
  • Severe hypotension: marked drop in blood pressure that may cause dizziness.
  • Anaphylactic reactions: sudden, life‑threatening allergic response.

Precautions & Warnings

When prescribing hydroxyzine, clinicians should consider several safety measures.

  • Assess hepatic function: adjust use in patients with liver impairment.
  • Use caution in the elderly: increased sensitivity to sedative effects.
  • Avoid concurrent CNS depressants: risk of additive sedation and respiratory depression.
  • Monitor for QT prolongation: especially when combined with other QT‑affecting agents.
  • Do not use in patients with known hypersensitivity to hydroxyzine or related compounds.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Hydroxyzine can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may cause severe hypotension.
  • CNS depressants (e.g., benzodiazepines, opioids): additive sedation and respiratory depression.
  • Anticholinergic drugs: increased anticholinergic burden leading to confusion or urinary retention.

Moderate Interactions (Monitor Closely)

  • Alcohol: enhances drowsiness and impairment.
  • Other antihistamines: may increase overall sedation.
  • QT‑prolonging agents: monitor ECG for potential arrhythmia.

Frequently Asked Questions

Hydroxyzinum Vp contains hydroxyzine hydrochloride, an H1‑antihistamine indicated for relief of allergic skin reactions, reduction of pruritus, short‑term management of anxiety, pre‑operative sedation, and control of nausea and vomiting in adult patients.

Hydroxyzine blocks peripheral H1 histamine receptors, preventing histamine‑induced itching, swelling, and vasodilation. Its anticholinergic and central nervous system activity also produces sedation, anxiolysis, and antiemetic effects, contributing to its therapeutic profile.

The prescribed dose of Hydroxyzinum Vp is determined by the treating physician based on the specific indication, patient age, weight, renal and hepatic function, and overall clinical response. Dosage may vary widely, and the prescriber provides the exact regimen.

Safety data for hydroxyzine during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To order Hydroxyzinum Vp, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and import documentation.

Hydroxyzine offers both antihistamine and anxiolytic properties, whereas first‑generation antihistamines such as diphenhydramine lack significant anxiolytic effect. Hydroxyzine generally produces less anticholinergic dry‑mouth and urinary retention than diphenhydramine, but both share sedation as a common side effect.

Store Hydroxyzinum Vp at ambient temperature, below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Hydroxyzinum Vp is administered orally. The tablet or capsule should be swallowed whole with a glass of water, unless the prescriber provides alternative instructions such as taking it with food to reduce gastrointestinal irritation.

Serious risks include cardiac arrhythmias, severe hypotension, and rare anaphylactic reactions. Patients should seek immediate medical attention if they experience palpitations, faintness, rapid heartbeat, swelling of the face or throat, or difficulty breathing.

Hydroxyzinum Vp should be avoided in individuals with known hypersensitivity to hydroxyzine or other piperazine antihistamines, in patients with severe hepatic impairment, and in those taking contraindicated medications such as MAO inhibitors. Caution is also advised for the elderly and patients with cardiac conduction disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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