Product image of Hyoscine Butylbromide Kalceks (Hyoscine Butylbromide) supplied by GNH India

Hyoscine Butylbromide Kalceks

Active Ingredient:
Hyoscine Butylbromide
Origin:
EU

Hyoscine Butylbromide Kalceks (Hyoscine Butylbromide)

Hyoscine Butylbromide, the active ingredient in Hyoscine Butylbromide Kalceks, is an anticholinergic antispasmodic presented as an injectable solution for intramuscular, intravenous, or subcutaneous use. It relieves smooth‑muscle spasm causing abdominal cramp, renal colic, biliary colic and symptoms of irritable bowel syndrome in adult patients.

GNH India supplies Hyoscine Butylbromide Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Hyoscine Butylbromide is used to relieve smooth‑muscle spasm in several gastrointestinal and urinary conditions.

  • Abdominal cramp and spasm: Relieves painful intestinal contractions and reduces discomfort.
  • Renal colic: Alleviates ureteral smooth‑muscle spasm associated with kidney stones.
  • Biliary colic: Reduces gall‑bladder muscle spasm and associated pain.
  • Irritable bowel syndrome: Decreases episodic abdominal pain and cramping.

How It Works

  • Hyoscine Butylbromide acts as a peripheral muscarinic receptor antagonist, blocking M1 and M3 receptors on smooth‑muscle cells. This inhibition reduces intracellular calcium influx, leading to decreased smooth‑muscle tone and relaxation of gastrointestinal, biliary and urinary tract musculature without significant central nervous system effects.

Side Effects

Adverse reactions may occur with Hyoscine Butylbromide use.

Common Side Effects

  • Dry mouth: Reduced salivary secretion causing throat discomfort.
  • Blurred vision: Transient difficulty focusing due to pupil dilation.
  • Tachycardia: Mild increase in heart rate.
  • Constipation: Slowed intestinal transit.
  • Urinary retention: Difficulty initiating urination.
  • Skin rash: Mild erythematous eruption.

Serious or Rare Side Effects

  • Anaphylaxis: Acute allergic reaction with airway compromise.
  • Severe hypotension: Marked drop in blood pressure requiring intervention.
  • Paralytic ileus: Complete cessation of intestinal motility.
  • Acute angle‑closure glaucoma: Sudden increase in intra‑ocular pressure.
  • Myocardial infarction: Rare cardiac ischemic event.
  • Stevens‑Johnson syndrome: Severe mucocutaneous reaction.

Precautions & Warnings

Before prescribing Hyoscine Butylbromide, clinicians should consider several safety measures.

  • Assess contraindications: Avoid in patients with known hypersensitivity to hyoscine butylbromide.
  • Monitor cardiac function: Use cautiously in patients with tachyarrhythmias or heart block.
  • Evaluate gastrointestinal obstruction: Contraindicated in suspected mechanical obstruction.
  • Caution in glaucoma: May exacerbate narrow‑angle glaucoma.
  • Pregnancy and lactation: Safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: Keep below 25°C, protect from moisture, retain in original packaging.

Avoid Interactions

Hyoscine Butylbromide can interact with other medicines; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Other anticholinergics (e.g., amitriptyline, diphenhydramine): additive anticholinergic load.
  • Antipsychotics with strong anticholinergic activity (e.g., clozapine): increased risk of severe dry mouth and tachycardia.
  • Concurrent antispasmodics: risk of excessive smooth‑muscle relaxation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia induced by hyoscine.
  • Opioids: additive constipation and reduced gastrointestinal motility.
  • Antihypertensives: potential additive hypotensive effect.
  • Digoxin: possible increase in serum levels.
  • Alcohol: may enhance anticholinergic side effects such as dizziness.

Frequently Asked Questions

Hyoscine Butylbromide Kalceks is indicated for the relief of smooth‑muscle spasm associated with abdominal cramp, renal colic, biliary colic and episodic abdominal pain in irritable bowel syndrome. It is administered by a healthcare professional to reduce painful contractions in the gastrointestinal, biliary and urinary tracts.

The drug blocks peripheral muscarinic (M1 and M3) receptors on smooth‑muscle cells, preventing acetylcholine‑mediated contraction. This antagonism lowers intracellular calcium, leading to relaxation of the affected smooth muscle and reduction of spasm without significant central nervous system activity.

The specific dose and route are determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and route of administration (intramuscular, intravenous or subcutaneous). Dosage should follow the prescriber’s instructions and local regulatory guidelines.

Safety data for hyoscine butylbromide in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Hyoscine Butylbromide is a peripheral anticholinergic, offering rapid onset when given intravenously or intramuscularly, and it does not cross the blood‑brain barrier, reducing central side effects. Other antispasmodics such as dicyclomine have more systemic anticholinergic activity and may cause greater sedation, while hyoscine provides targeted smooth‑muscle relaxation with a favorable safety profile for acute spasm.

Store the product at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly sealed to maintain sterility.

The medication is supplied as a sterile injectable solution and may be given intramuscularly, intravenously, or subcutaneously by a qualified healthcare professional. The route and rate of administration are chosen according to the clinical situation and the prescriber’s judgment.

Serious adverse events, although rare, include anaphylactic reactions, severe hypotension, paralytic ileus, acute angle‑closure glaucoma, myocardial infarction and severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of these conditions, and treatment should be discontinued immediately if they occur.

The drug is contraindicated in individuals with known hypersensitivity to hyoscine butylbromide, in patients with mechanical gastrointestinal obstruction, and in those with narrow‑angle glaucoma. Caution is also advised for patients with severe cardiac conduction disorders, uncontrolled tachyarrhythmias, or significant hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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