Product image of Hyoscine Martindale Pharma (Hyoscine Hydrobromide) supplied by GNH India

Hyoscine Martindale Pharma

Active Ingredient:
Hyoscine Hydrobromide
Origin:
EU

Hyoscine Martindale Pharma (Hyoscine Hydrobromide)

Hyoscine hydrobromide, the active ingredient in Hyoscine Martindale Pharma, is an anticholinergic presented as a sterile injectable solution for intramuscular, intravenous and subcutaneous use. It is employed to relieve motion‑induced nausea, postoperative nausea and vomiting, and gastrointestinal spasm in adult patients.
GNH India supplies Hyoscine Martindale Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macarthys Laboratories Ltd

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Indications & Clinical Uses

Hyoscine hydrobromide acts on the muscarinic cholinergic pathway to reduce involuntary smooth‑muscle activity and vestibular stimulation.

  • Motion sickness: alleviates nausea, vomiting and dizziness associated with travel.
  • Postoperative nausea and vomiting: prevents or reduces nausea after surgical procedures.
  • Gastrointestinal spasm: relaxes smooth muscle to relieve abdominal cramping and discomfort.

How It Works

  • Hyoscine hydrobromide competitively blocks muscarinic acetylcholine receptors, inhibiting parasympathetic neurotransmission. This antagonism reduces secretions and smooth‑muscle contractility, thereby diminishing vestibular input and gastrointestinal spasm, and suppressing the central vomiting centre.

Side Effects

Hyoscine hydrobromide may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Dry mouth: reduced salivary flow leading to thirst.
  • Blurred vision: transient difficulty focusing.
  • Drowsiness: mild sedation or fatigue.
  • Constipation: slowed intestinal transit.
  • Urinary retention: difficulty initiating urination.

Serious or Rare Side Effects

  • Tachycardia: rapid heart rate requiring monitoring.
  • Confusion or delirium: especially in elderly patients.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Acute glaucoma: sudden increase in intra‑ocular pressure.
  • Hyperthermia: elevated body temperature in susceptible individuals.

Precautions & Warnings

When using Hyoscine hydrobromide, consider the following safety measures.

  • Assess cardiac status: monitor heart rate and rhythm in patients with known arrhythmias.
  • Evaluate glaucoma risk: avoid use in individuals with narrow‑angle glaucoma.
  • Review urinary function: caution in patients with prostatic hypertrophy or urinary obstruction.
  • Consider age: elderly patients may be more sensitive to anticholinergic effects.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk, as safety data are limited.
  • Store at ambient temperature: keep below 25°C, in the original container, protected from moisture and light.

Avoid Interactions

Hyoscine hydrobromide can interact with several drug classes.

Major Interactions (Avoid)

  • Other anticholinergics: additive anticholinergic burden may precipitate severe dryness, tachycardia, or confusion.
  • Monoamine oxidase inhibitors (MAOIs): may enhance central nervous system effects.

Moderate Interactions (Monitor Closely)

  • Opioids: combined use can increase the risk of constipation and urinary retention.
  • Antihistamines: may potentiate sedation and dry‑mouth effects.
  • Beta‑blockers: may mask tachycardia caused by hyoscine.
  • CNS depressants: additive sedation may occur.
  • Drugs affecting QT interval: monitor cardiac rhythm when used together.

Frequently Asked Questions

Hyoscine Martindale Pharma is indicated for the prevention and treatment of motion‑induced nausea and vomiting, postoperative nausea and vomiting, and for relief of gastrointestinal smooth‑muscle spasm that causes abdominal cramping.

Hyoscine hydrobromide blocks muscarinic acetylcholine receptors, reducing parasympathetic activity. This antagonism diminishes vestibular stimulation, suppresses the central vomiting centre, and relaxes smooth muscle, thereby alleviating nausea, vomiting, and spasm.

The specific dose and administration schedule are determined by the prescribing clinician based on the patient’s condition, age, weight, and response. Dosage information is provided on the prescription label.

Safety data in pregnancy and lactation are limited. The product should only be used if the potential therapeutic benefit justifies any potential risk to the fetus or infant, and this decision must be made by the treating physician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hyoscine hydrobromide is a potent muscarinic antagonist with rapid onset when given intravenously or intramuscularly, making it suitable for acute nausea and spasm. Compared with agents like scopolamine patches, hyoscine provides more flexible dosing and quicker reversal of symptoms.

Store the injectable solution at ambient temperature, below 25 °C. Keep it in the original packaging, protect from moisture and direct light, and avoid freezing.

The product is supplied as a sterile injectable solution and may be administered by intramuscular, intravenous or subcutaneous injection, according to the prescriber’s instructions and the clinical situation.

Serious adverse events include tachycardia, severe confusion or delirium (particularly in the elderly), acute angle‑closure glaucoma, and rare allergic reactions such as anaphylaxis. Patients should be monitored for these signs, especially after high‑dose administration.

Patients with known hypersensitivity to hyoscine or other anticholinergics, those with narrow‑angle glaucoma, uncontrolled urinary retention, severe cardiac arrhythmias, or who are pregnant without a clear benefit should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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