Product image of Hyperforat (St. John's Wort Dry Extract (3.5-6.0:1), Extraction Solvent: Ethanol 60% (M/M)) supplied by GNH India

Hyperforat

Active Ingredient:
St. John's Wort Dry Extract (3.5-6.0:1), Extraction Solvent: Ethanol 60% (M/M)
Origin:
EU

Hyperforat (St. John's Wort Dry Extract (3.5-6.0:1), Extraction Solvent: Ethanol 60% (M/M))

St. John's Wort Dry Extract, the active ingredient in Hyperforat, is a herbal antidepressant presented as an oral herbal extract for oral use. Extracted with 60 % ethanol, it is marketed in the EU and is intended to support mood in individuals experiencing mild to moderate depression and seasonal affective disorder.

GNH India supplies Hyperforat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing consistent quality, regulatory compliance and reliable logistics for this herbal antidepressant across global markets.

Manufacturer / TM Owner

Dr. Gustav Klein Gmbh & Co Kg

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Indications & Clinical Uses

  • Hyperforat, a herbal antidepressant, is used to address mood disorders related to neurotransmitter imbalances.
  • Mild to moderate depression: helps improve mood and reduce depressive symptoms.
  • Seasonal affective disorder: alleviates low mood associated with seasonal changes.
  • Adjustment-related low mood: supports emotional balance during stressful life adjustments.

How It Works

  • St. John's Wort Dry Extract modulates neurotransmitter activity by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, thereby increasing their synaptic concentrations. It also influences intracellular signaling pathways and may affect the expression of neurotrophic factors, contributing to its antidepressant effects.

Side Effects

St. John's Wort Dry Extract may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort
  • Dizziness
  • Headache
  • Fatigue
  • Skin photosensitivity
  • Dry mouth

Serious or Rare Side Effects

  • Serotonin syndrome when combined with serotonergic drugs
  • Severe allergic reactions, including anaphylaxis
  • Hyponatremia
  • Elevation of liver enzymes
  • Psychotic episodes
  • Cardiac arrhythmias

Precautions & Warnings

When using Hyperforat, consider the following precautions:

  • Assess psychiatric history: ensure appropriate indication before initiating therapy.
  • Monitor for drug interactions: review concomitant medications for serotonergic activity.
  • Avoid use in pregnancy unless advised: safety data are insufficient.
  • Caution in breastfeeding: potential transfer to infant via milk.
  • Discontinue before surgery: risk of increased bleeding.
  • Protect from sunlight: photosensitivity may occur.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Hyperforat can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Selective serotonin reuptake inhibitors (SSRIs): risk of serotonin syndrome.
  • Monoamine oxidase inhibitors (MAOIs): risk of severe serotonin toxicity.
  • Tricyclic antidepressants: increased plasma concentrations.
  • Anticoagulants (e.g., warfarin): enhanced bleeding risk.
  • Oral contraceptives: reduced hormonal efficacy.

Moderate Interactions (Monitor Closely)

  • Antiepileptics (phenytoin, carbamazepine): decreased drug levels.
  • Immunosuppressants (cyclosporine, tacrolimus): reduced effectiveness.
  • Digoxin: lowered serum concentrations.
  • HIV protease inhibitors: diminished antiviral activity.
  • Other CYP3A4 substrates: possible altered metabolism.

Frequently Asked Questions

Hyperforat is an oral herbal preparation containing St. John's Wort dry extract. It is used to support mood in adults with mild to moderate depression and to alleviate symptoms of seasonal affective disorder, helping to improve overall emotional well‑being.

The extract modulates neurotransmitter activity by inhibiting the reuptake of serotonin, norepinephrine and dopamine, which raises their levels in the brain. This action helps correct the chemical imbalances that are associated with depressive mood states.

The appropriate dose of Hyperforat is determined by the prescribing healthcare professional based on the individual’s condition, age, and response. Clinicians may adjust the regimen according to therapeutic goals and tolerability, so patients should follow the specific instructions provided by their prescriber.

Safety data for St. John's Wort during pregnancy and lactation are limited. It is generally advised that pregnant or breastfeeding women consult their physician before using Hyperforat, as potential risks to the fetus or infant have not been fully established.

To place an order, visit the product page on gnhindia.com, submit an enquiry with the required quantity, and provide institutional or trade credentials. GNH India’s team will verify the information, then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Hyperforat is a herbal antidepressant, whereas many alternatives are synthetic pharmaceuticals such as SSRIs or SNRIs. Clinical studies suggest comparable efficacy for mild to moderate depression, but the side‑effect profile differs; Hyperforat is associated with photosensitivity and drug‑interaction risks, while synthetic agents may have other metabolic or sexual side effects.

Store Hyperforat at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging is tightly sealed to maintain stability throughout its shelf life.

Hyperforat is taken orally as directed by a healthcare professional, typically with water and optionally with food to reduce gastrointestinal discomfort. The exact timing and frequency should follow the prescriber’s instructions for optimal therapeutic effect.

The most serious risks include serotonin syndrome when combined with other serotonergic drugs, severe allergic reactions such as anaphylaxis, and marked photosensitivity leading to sunburn. Patients should seek immediate medical attention if they experience rapid heart rate, high fever, agitation, or severe skin reactions.

Hyperforat should be avoided by individuals currently taking MAO inhibitors, SSRIs, tricyclic antidepressants, or other serotonergic medications due to the risk of serotonin syndrome. It is also contraindicated in pregnant or breastfeeding women without medical advice, and in patients with known hypersensitivity to St. John's Wort or its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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