Product image of Hypericum Holland And Barrett (Dry Extract Of St. John's Wort (5-7:1), Extraction Solvent: Ethanol 60% V/V) supplied by GNH India

Hypericum Holland And Barrett

Active Ingredient:
Dry Extract Of St. John's Wort (5-7:1), Extraction Solvent: Ethanol 60% V/V
Origin:
EU

Hypericum Holland And Barrett (Dry Extract Of St. John's Wort (5-7:1), Extraction Solvent: Ethanol 60% V/V)

Hypericum perforatum (St. John's Wort) extract, the active ingredient in Hypericum Holland And Barrett, is a herbal antidepressant presented as a dry ethanol‑based extract (5‑7:1) for oral use. It is employed to support mood in adults with mild to moderate depressive symptoms and seasonal affective disorder, acting as a natural alternative to conventional antidepressants.

GNH India supplies Hypericum Holland And Barrett as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide, providing consistent quality for global distribution.

Manufacturer / TM Owner

Holland & Barrett Limited

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Indications & Clinical Uses

Hypericum Holland And Barrett, a St. John's Wort extract, acts on neurotransmitter pathways associated with mood regulation.

  • Mild to moderate depression: helps alleviate depressive symptoms and improve mood in adults.
  • Seasonal affective disorder: reduces winter‑related mood decline and associated fatigue.
  • Stress‑related mood disturbances: supports emotional balance during periods of heightened stress.

How It Works

  • Hypericum perforatum dry extract contains hypericin and hyperforin, which inhibit the reuptake of serotonin, dopamine and norepinephrine, thereby increasing their synaptic availability. It also modulates GABA receptor activity and influences inflammatory pathways, contributing to its mood‑stabilising effects. The combined actions on multiple neurotransmitter systems underlie its antidepressant properties.

Side Effects

Hypericum Holland And Barrett may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, stomach upset or diarrhoea.
  • Photosensitivity: increased sensitivity to sunlight leading to skin redness.
  • Dizziness or light‑headedness.
  • Fatigue or mild drowsiness.
  • Dry mouth.

Serious or Rare Side Effects

  • Serotonin syndrome: potentially life‑threatening condition when combined with serotonergic drugs.
  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Manic or hypomanic episodes in susceptible individuals.
  • Significant liver enzyme elevation or hepatic injury.

Precautions & Warnings

When considering Hypericum Holland And Barrett, several safety measures should be observed.

  • Contraindicated in severe depression: not a substitute for professional psychiatric care.
  • Avoid concurrent use with SSRIs, MAO inhibitors or other serotonergic agents: risk of serotonin syndrome.
  • Caution in pregnancy and breastfeeding: safety not established; consult a healthcare provider.
  • Limit sun exposure: use protective clothing and sunscreen due to photosensitivity risk.
  • Monitor for mood switching: watch for signs of mania or hypomania.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct light.

Avoid Interactions

Hypericum Holland And Barrett interacts with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Selective serotonin reuptake inhibitors (SSRIs): may precipitate serotonin syndrome.
  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypertensive reactions.
  • Warfarin: can reduce anticoagulant effect and increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may decrease hormonal efficacy, leading to unintended pregnancy.
  • Anticonvulsants (e.g., carbamazepine, phenytoin): may lower plasma levels, reducing seizure control.

Frequently Asked Questions

Hypericum Holland And Barrett is an oral herbal supplement that contains a standardized dry extract of St. John's Wort. It is primarily used to support mood in adults experiencing mild to moderate depressive symptoms and to alleviate the low‑energy, low‑mood episodes associated with seasonal affective disorder.

The extract of St. John's Wort contains bioactive compounds such as hypericin and hyperforin. These substances inhibit the reuptake of serotonin, dopamine and norepinephrine, increasing their levels in the brain, and also modulate GABA activity. The combined effect helps improve mood and reduce depressive symptoms.

The appropriate dose is determined by a qualified healthcare professional based on the individual’s condition, age, weight and other medications. Prescribers typically follow established dosing guidelines for St. John's Wort extracts, but the exact regimen should be confirmed with the treating clinician.

Safety data for St. John's Wort during pregnancy and lactation are limited, and the product is generally not recommended for use in these periods. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative options with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Unlike synthetic antidepressants such as SSRIs, Hypericum Holland And Barrett is a plant‑derived product that influences several neurotransmitter pathways simultaneously. It may have a milder side‑effect profile for some users, but it also carries a higher risk of drug‑drug interactions, especially with serotonergic agents, and its efficacy can be more variable.

Store Hypericum Holland And Barrett at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in the original packaging until use to maintain product stability.

The product is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with respect to meals may help reduce gastrointestinal discomfort. Patients should follow the dosing instructions provided by their prescriber.

The most significant risks include the potential for serotonin syndrome when combined with other serotonergic drugs, severe photosensitivity leading to sunburn, and the possibility of triggering manic or hypomanic episodes in individuals with bipolar tendencies. Prompt medical attention is required if any of these serious reactions occur.

Individuals taking SSRIs, MAO inhibitors, warfarin, oral contraceptives, or anticonvulsant medications should avoid or closely monitor use. It is also unsuitable for people with severe depression, those who are pregnant or breastfeeding, and patients with a history of photosensitivity or bipolar disorder without specialist guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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