Product image of Hypericum (St. John´s Wort Dry Extract, Quantified, Der 3-7:1, Extraction Solvent: Methanol 80 % (V/V)) supplied by GNH India

Hypericum

Active Ingredient:
St. John´s Wort Dry Extract, Quantified, Der 3-7:1, Extraction Solvent: Methanol 80 % (V/V)
Origin:
EU

Hypericum (St. John´s Wort Dry Extract, Quantified, Der 3-7:1, Extraction Solvent: Methanol 80 % (V/V))

St. John's Wort, the active ingredient in Hypericum, is a herbal presented as a dry extract for oral use. It is used to support mood and may be considered in mild to moderate depression in adults.

GNH India supplies Hypericum as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Willmar Schwabe Gmbh & Co. Kg

1
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Indications & Clinical Uses

  • Hypericum (St. John's Wort) is used as an herbal antidepressant acting on monoamine neurotransmission.
  • Depression: helps improve mood and reduce depressive symptoms in mild to moderate cases.
  • Seasonal affective disorder: may alleviate mood changes associated with seasonal variation.

How It Works

  • St. John's Wort dry extract inhibits the reuptake of serotonin, norepinephrine, and dopamine, thereby increasing their synaptic concentrations. It also modulates glutamatergic neurotransmission and influences intracellular signaling pathways, contributing to its antidepressant activity.

Side Effects

Hypericum may cause a range of adverse reactions.

Common Side Effects

  • Photosensitivity: increased skin sensitivity to sunlight.
  • Gastrointestinal upset: nausea, stomach discomfort, or diarrhea.
  • Fatigue or dizziness: feelings of tiredness or light‑headedness.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Serotonin syndrome: potentially life‑threatening condition when combined with other serotonergic agents.
  • Severe allergic reactions: rash, itching, or swelling.
  • Liver toxicity: abnormal liver function tests or hepatitis.
  • Mania or hypomania: activation of mood elevation in susceptible individuals.

Precautions & Warnings

  • When using Hypericum, consider the following precautions.
  • Avoid sun exposure: increased risk of photosensitivity reactions.
  • Monitor mood changes: possible activation of mania or hypomania.
  • Do not combine with serotonergic drugs: risk of serotonin syndrome.
  • Use caution in hepatic impairment: metabolism may be altered.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Hypericum interacts with several medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • SSRIs (e.g., fluoxetine, sertraline): risk of serotonin syndrome.
  • MAO inhibitors (e.g., phenelzine): heightened serotonergic activity.
  • Tricyclic antidepressants (e.g., amitriptyline): increased plasma levels.
  • Anticoagulants (e.g., warfarin): enhanced anticoagulant effect.
  • Oral contraceptives: reduced efficacy leading to unintended pregnancy.

Moderate Interactions (Monitor Closely)

  • Antiepileptics (e.g., phenytoin): decreased drug concentrations.
  • Immunosuppressants (e.g., cyclosporine): altered metabolism and reduced effectiveness.

Frequently Asked Questions

Hypericum, containing St. John's Wort dry extract, is used as an herbal antidepressant to support mood in mild to moderate depression and may also help with seasonal affective disorder.

St. John's Wort inhibits the reuptake of serotonin, norepinephrine, and dopamine, increasing their levels in the brain, and also modulates glutamatergic neurotransmission, which together contribute to its antidepressant effect.

The appropriate dose of Hypericum is determined by the prescribing healthcare professional based on the individual’s condition, age, and response; patients should follow the prescriber’s instructions.

Safety data for Hypericum in pregnancy and lactation are limited; it is generally advised to avoid use unless clearly indicated by a qualified healthcare provider.

To order Hypericum, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Unlike synthetic antidepressants, Hypericum is a herbal preparation that primarily inhibits monoamine reuptake and may have fewer drug‑specific side effects, but it has a higher potential for interactions with many prescription medicines.

Store Hypericum at ambient temperature, below 25 °C, in its original packaging, protected from moisture and direct sunlight to maintain product stability.

Hypericum is taken orally, typically as a dry extract capsule or tablet, with water. The exact administration instructions should follow the prescriber’s guidance.

The most serious risks include serotonin syndrome when combined with other serotonergic agents, severe photosensitivity, liver toxicity, and the possible induction of mania or hypomania in susceptible individuals.

Hypericum should be avoided by individuals taking MAO inhibitors, SSRIs, tricyclic antidepressants, anticoagulants, oral contraceptives, or those with known hypersensitivity to St. John's Wort.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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