Product image of Hyperlipen (Ciprofibrate) supplied by GNH India

Hyperlipen

Active Ingredient:
Ciprofibrate
Origin:
EU

Hyperlipen (Ciprofibrate)

Ciprofibrate, the active ingredient in Hyperlipen, is a fibrate presented as an oral formulation for oral use. It treats hypertriglyceridemia and mixed dyslipidemia in adult patients.
GNH India supplies Hyperlipen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Belgium

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Indications & Clinical Uses

Hyperlipen is a fibrate that acts on lipid metabolism to lower elevated triglyceride levels and improve overall lipid profiles.

  • Hypertriglyceridemia: reduces serum triglycerides and lowers risk of pancreatitis.
  • Mixed dyslipidemia: decreases triglycerides while modestly raising HDL‑cholesterol and lowering LDL‑cholesterol.

How It Works

  • Ciprofibrate activates peroxisome proliferator‑activated receptor alpha (PPARα), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid β‑oxidation and down‑regulates enzymes responsible for triglyceride synthesis, leading to increased clearance of triglyceride‑rich lipoproteins and improved lipid parameters.

Side Effects

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain, or dyspepsia.
  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness.
  • Constipation or loose stools.
  • Elevated liver enzymes: mild, transient increases.

Serious or Rare Side Effects

  • Myopathy or rhabdomyolysis, especially when combined with statins.
  • Severe hepatic dysfunction or hepatitis.
  • Gallstone formation.
  • Acute pancreatitis.
  • Anaphylactic or severe allergic reactions.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline liver and renal function and review concomitant medications.

  • Liver monitoring: check hepatic enzymes prior to treatment and periodically thereafter.
  • Renal monitoring: evaluate kidney function, especially in patients with pre‑existing impairment.
  • Gallbladder disease: avoid use in patients with active gallstones or biliary disease.
  • Statin co‑therapy: assess risk of myopathy and adjust doses if necessary.
  • Pregnancy and lactation: use only if potential benefits justify potential risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ciprofibrate may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Statins (especially high‑dose): increased risk of myopathy and rhabdomyolysis.
  • Gemfibrozil: additive effect on muscle toxicity.
  • Warfarin: potentiation of anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely)

  • Niacin: heightened flushing and potential liver stress.
  • Digoxin: possible increase in serum digoxin concentrations.

Frequently Asked Questions

Hyperlipen contains ciprofibrate, a fibrate class medication prescribed to lower elevated triglyceride levels and improve lipid profiles in patients with hypertriglyceridemia or mixed dyslipidemia.

Ciprofibrate activates the nuclear receptor PPARα, which increases the expression of enzymes responsible for fatty‑acid oxidation and reduces the synthesis of triglycerides, thereby enhancing clearance of triglyceride‑rich lipoproteins from the bloodstream.

The dosage of Hyperlipen is individualized by the prescribing clinician based on the patient’s lipid levels, renal and hepatic function, and overall risk profile. The prescriber determines the appropriate strength and frequency.

Safety data for ciprofibrate during pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and only under medical supervision.

To request Hyperlipen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with statins, which primarily lower LDL‑cholesterol, ciprofibrate is more effective at reducing triglycerides and modestly raising HDL‑cholesterol. Unlike other fibrates such as gemfibrozil, ciprofibrate may have a lower incidence of certain drug‑drug interactions but still requires caution when combined with statins.

Hyperlipen should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Hyperlipen is taken orally, usually once daily with a meal to enhance absorption and reduce gastrointestinal upset. Patients should swallow the tablet whole with water and follow the prescriber’s instructions regarding timing and food.

The most serious adverse events include myopathy or rhabdomyolysis, especially when used with statins, severe liver injury, gallstone formation, and rare cases of acute pancreatitis. Patients should report unexplained muscle pain, dark urine, jaundice, or severe abdominal pain promptly.

Hyperlipen is contraindicated in patients with active liver disease, severe renal impairment, known gallbladder disease, or a documented hypersensitivity to ciprofibrate or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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