Product image of Hyperlipen (Ciprofibrate) supplied by GNH India

Hyperlipen

Active Ingredient:
Ciprofibrate
Origin:
EU

Hyperlipen (Ciprofibrate)

Ciprofibrate, the active ingredient in Hyperlipen, is a fibrate presented as an oral tablet for oral use. It is used to lower elevated blood lipids, particularly triglycerides, in adults with lipid disorders.

GNH India supplies Hyperlipen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Belgium

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Indications & Clinical Uses

  • Hyperlipen (ciprofibrate) belongs to the fibrate class and is employed to manage disorders of lipid metabolism.
  • Hyperlipidemia: reduces total cholesterol and LDL‑cholesterol levels.
  • Hypertriglyceridemia: lowers elevated plasma triglycerides.
  • Mixed dyslipidemia: improves overall lipid profile by decreasing triglycerides and modestly raising HDL‑cholesterol.

How It Works

  • Ciprofibrate activates peroxisome proliferator‑activated receptor alpha (PPARα), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid β‑oxidation. This enhances the catabolism of triglyceride‑rich lipoproteins and reduces hepatic production of very‑low‑density lipoprotein, leading to lower plasma triglyceride concentrations and modest improvements in other lipid parameters.

Side Effects

Ciprofibrate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort such as nausea or abdominal pain.
  • Elevated liver enzymes indicating mild hepatic stress.
  • Muscle aches or weakness, especially during physical activity.
  • Headache or dizziness.

Serious or Rare Side Effects

  • Myopathy or rhabdomyolysis, presenting as severe muscle pain and dark urine.
  • Significant hepatic injury with jaundice or hepatitis.
  • Gallstone formation due to altered cholesterol metabolism.
  • Severe allergic reactions including rash, swelling, or anaphylaxis.

Precautions & Warnings

  • Before initiating therapy with Hyperlipen, several safety considerations should be observed.
  • Liver function monitoring: assess baseline enzymes and repeat periodically.
  • Renal function assessment: evaluate creatinine clearance in patients with kidney disease.
  • Drug interactions: review concurrent medications that affect lipid metabolism.
  • Pregnancy and lactation: avoid use unless clearly indicated by a physician.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Ciprofibrate can interact with other agents, requiring careful management.

Major Interactions (Avoid)

  • Statins (e.g., simvastatin, atorvastatin): increased risk of myopathy.
  • Anticoagulants (e.g., warfarin): potentiation of anticoagulant effect.
  • Gemfibrozil: additive risk of severe muscle toxicity.

Moderate Interactions (Monitor Closely)

  • Oral hypoglycemic agents: possible alteration of blood glucose control.
  • Thyroid hormones: may affect thyroid function tests.
  • Cyclosporine: potential increase in ciprofibrate plasma levels.

Frequently Asked Questions

Hyperlipen, containing ciprofibrate, is prescribed to manage elevated blood lipids, specifically hyperlipidemia and hypertriglyceridemia. It helps lower triglyceride levels and can improve overall cholesterol profiles in adults with these lipid disorders.

Ciprofibrate activates the nuclear receptor PPARα, which increases the expression of enzymes involved in fatty‑acid oxidation. This accelerates the breakdown of triglyceride‑rich lipoproteins and reduces hepatic production of VLDL, resulting in lower plasma triglyceride concentrations.

The specific dose of Hyperlipen is determined by the prescribing clinician based on the patient’s lipid profile, renal and hepatic function, and other individual factors. Dosage adjustments should follow the prescriber’s instructions and local prescribing guidelines.

Safety of ciprofibrate in pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Hyperlipen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Compared with statins, ciprofibrate primarily reduces triglycerides and modestly raises HDL‑cholesterol, whereas statins mainly lower LDL‑cholesterol. Fibrates like Hyperlipen are often chosen when triglyceride reduction is the primary therapeutic goal or when statin therapy alone is insufficient.

Hyperlipen should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Hyperlipen is taken orally, usually with a meal to improve absorption and reduce gastrointestinal discomfort. The tablet should be swallowed whole with water and not crushed or chewed, unless otherwise directed by a healthcare provider.

The most serious adverse events include myopathy or rhabdomyolysis, especially when combined with statins, significant liver enzyme elevations indicating hepatic injury, and rare cases of gallstone formation. Patients should report unexplained muscle pain, dark urine, or jaundice promptly.

Hyperlipen is contraindicated in patients with active liver disease, severe renal impairment, known hypersensitivity to ciprofibrate or other fibrates, and in individuals taking gemfibrozil. It should also be avoided in patients with a history of gallbladder disease unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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