Product image of Hypoloc (Nebivolol) supplied by GNH India

Hypoloc

Active Ingredient:
Nebivolol
Origin:
EU

Hypoloc (Nebivolol)

Nebivolol, the active ingredient in Hypoloc, is a beta blocker (selective β1‑adrenergic antagonist) presented as an oral tablet for oral use. It treats hypertension and heart failure in adult patients.

GNH India supplies Hypoloc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Nebivolol is a selective β1‑adrenergic antagonist used in cardiovascular disease management.

  • Hypertension: lowers elevated blood pressure and reduces cardiovascular risk.
  • Heart failure: improves left‑ventricular function and decreases hospitalization rates.
  • Left ventricular dysfunction: supports cardiac output in patients with reduced ejection fraction.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, reducing heart rate and contractility. In addition, it stimulates endothelial nitric‑oxide synthase, leading to nitric‑oxide‑mediated vasodilation, which further contributes to blood‑pressure reduction without significant β2 blockade.

Side Effects

Nebivolol may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness: often related to blood‑pressure lowering.
  • Fatigue: general tiredness or lack of energy.
  • Nasal congestion: mild blockage of nasal passages.
  • Diarrhea: loose stools, usually transient.
  • Bradycardia: slower than normal heart rate.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Acute heart failure decompensation: worsening of heart failure symptoms.
  • Bronchospasm: constriction of airways, especially in patients with asthma.
  • Liver enzyme elevation: abnormal hepatic function tests.

Precautions & Warnings

Nebivolol requires careful assessment before and during therapy.

  • Cardiovascular assessment: evaluate heart rate, blood pressure, and cardiac function.
  • Concomitant β‑blockers: avoid additive effects that may cause excessive bradycardia.
  • Renal impairment: adjust monitoring as clearance may be reduced.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Pregnancy and lactation: safety not established; discuss risks with a healthcare professional.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with several drug classes, influencing its safety profile.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: may cause profound bradycardia and hypotension.
  • Strong CYP2D6 inhibitors (e.g., paroxetine, quinidine): increase nebivolol plasma levels.
  • Calcium channel blockers (verapamil, diltiazem): additive negative‑inotropic and AV‑node effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate orthostatic hypotension.
  • Antihypertensive agents (ACE inhibitors, ARBs): monitor for excessive blood‑pressure reduction.
  • Antidiabetic drugs: beta‑blockade can mask hypoglycaemia symptoms; adjust glucose monitoring.

Frequently Asked Questions

Hypoloc contains nebivolol, a selective β1‑adrenergic blocker indicated for the management of essential hypertension and for treating heart failure in adults when prescribed by a qualified clinician.

Nebivolol blocks β1‑adrenergic receptors in the heart, reducing heart rate and contractility, while simultaneously enhancing nitric‑oxide release from the endothelium, which causes vasodilation and contributes to lower blood pressure.

The dosage of nebivolol is individualized by the prescribing physician based on the patient’s clinical condition, blood‑pressure targets, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of nebivolol in pregnancy and lactation has not been established. Healthcare providers should weigh potential benefits against possible risks and discuss alternatives with pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nebivolol is distinguished by its high β1 selectivity and additional nitric‑oxide‑mediated vasodilation, which may result in fewer metabolic side effects compared with non‑selective beta blockers. Clinical choice depends on patient profile, comorbidities and physician preference.

Store Hypoloc at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat and direct sunlight to maintain potency throughout the shelf‑life.

Hypoloc is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically advised.

Serious risks include severe hypotension, bradycardia, acute heart‑failure decompensation, bronchospasm in susceptible individuals, and rare liver‑enzyme elevations. Patients should seek immediate medical attention if they experience dizziness, fainting, worsening shortness of breath, or jaundice.

Nebivolol is contraindicated in patients with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and in those with uncompensated heart failure. Caution is also advised for individuals with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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