Product image of Hytrin 5 (Terazosin Hydrochloride Dihydrate) supplied by GNH India

Hytrin 5

Active Ingredient:
Terazosin Hydrochloride Dihydrate
Origin:
EU

Hytrin 5 (Terazosin Hydrochloride Dihydrate)

Terazosin, the active ingredient in Hytrin 5, is a alpha-1 adrenergic blocker presented as an oral tablet for oral use. It is employed to lower high blood pressure and to relieve urinary obstruction caused by an enlarged prostate in adult patients. The product conforms to European Union quality standards and is distributed under a prescription‑only status.

GNH India supplies Hytrin 5 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring reliable logistics and regulatory compliance globally.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Terazosin is used to treat conditions related to vascular tone and prostate smooth‑muscle tone.

  • Hypertension: reduces systemic vascular resistance, helping to lower elevated blood pressure.
  • Benign prostatic hyperplasia: relaxes smooth muscle in the prostate and bladder neck, improving urinary flow and reducing symptoms.
  • Lower urinary tract symptoms: alleviates urgency, frequency, and nocturia associated with prostate enlargement.

How It Works

  • Terazosin selectively antagonizes alpha‑1 adrenergic receptors located on vascular smooth muscle and in the prostate and bladder neck. By blocking these receptors, it prevents norepinephrine‑mediated contraction, leading to vasodilation and decreased peripheral resistance, as well as reduced smooth‑muscle tone in the urinary tract, which lowers blood pressure and improves urinary outflow.

Side Effects

Terazosin may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness, especially on standing.
  • Headache.
  • Fatigue or tiredness.
  • Nasal congestion or runny nose.
  • Peripheral edema.
  • Orthostatic hypotension.

Serious or Rare Side Effects

  • Severe hypotension leading to fainting.
  • Syncope.
  • Priapism (prolonged erection).
  • Acute heart failure exacerbation.
  • Significant liver enzyme elevation.
  • Severe allergic reactions such as rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating terazosin therapy, several safety considerations should be observed.

  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Dose titration: start low and increase gradually as directed by the prescriber.
  • Concurrent antihypertensives: assess risk of additive blood pressure lowering.
  • Renal or hepatic impairment: adjust dose or monitor closely.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Terazosin can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors: may increase terazosin plasma levels, risking hypotension.
  • Other alpha‑blockers: additive vasodilatory effect leading to severe hypotension.
  • Sildenafil and other PDE5 inhibitors: can cause profound blood pressure drops.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance orthostatic hypotension, monitor volume status.
  • Antihypertensive agents (ACE inhibitors, ARBs, beta‑blockers): may require dose adjustment.
  • Alcohol: can increase dizziness and hypotensive effects.

Frequently Asked Questions

Hytrin 5 contains the active ingredient terazosin, which is prescribed to lower high blood pressure and to treat benign prostatic hyperplasia. In hypertension, it helps reduce vascular resistance, while in BPH it relaxes prostate and bladder‑neck smooth muscle to improve urinary flow.

Terazosin works by selectively blocking alpha‑1 adrenergic receptors on blood vessels and in the prostate. This blockade prevents norepinephrine‑induced contraction, causing blood vessels to dilate and reducing peripheral resistance, and it also relaxes smooth muscle in the urinary tract, easing urinary obstruction.

The exact dose of Hytrin 5 is determined by the prescribing clinician based on the individual’s medical condition, response, and tolerability. Physicians typically start with a low dose and may adjust it gradually to achieve the desired blood‑pressure control or symptom relief.

Safety data for terazosin in pregnancy and lactation are limited, and the drug is generally not recommended for use in pregnant or nursing women unless the potential benefit outweighs the risk. Physicians should evaluate each case carefully before prescribing.

To request Hytrin 5, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hytrin 5 (terazosin) is an older, non‑selective alpha‑1 blocker, offering both antihypertensive and BPH benefits. Compared with newer agents such as tamsulosin, which is more prostate‑selective, terazosin may cause more systemic blood‑pressure effects but can be advantageous when both hypertension and BPH need treatment.

Hytrin 5 should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Hytrin 5 is taken orally, usually as a whole tablet swallowed with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any specific dietary considerations.

The most serious risks include severe hypotension, syncope, and priapism. Patients should be alert for sudden dizziness, fainting spells, or a prolonged erection lasting more than four hours, and seek immediate medical attention if these events occur.

Hytrin 5 should be avoided in individuals with known hypersensitivity to terazosin or any component of the formulation, in patients with severe liver disease, and in those who have experienced severe hypotension or syncope with prior alpha‑blocker therapy. A healthcare professional must evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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