Product image of Ialugen Plus (Sulfadiazine Silver, Sodium Hyaluronate) supplied by GNH India

Ialugen Plus

Active Ingredient:
Sulfadiazine Silver, Sodium Hyaluronate
Origin:
EU

Ialugen Plus (Sulfadiazine Silver, Sodium Hyaluronate)

Silver sulfadiazine and sodium hyaluronate, the active ingredients in Ialugen Plus, are a sulfonamide antibacterial and a wound‑healing polymer presented as a topical cream for cutaneous use. It treats second‑degree and superficial third‑degree burns and other traumatic skin wounds by preventing bacterial infection and supporting tissue repair.

GNH India supplies Ialugen Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Pharma Kft

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Indications & Clinical Uses

Ialugen Plus is a topical anti‑infective indicated for burn‑related skin conditions and traumatic wounds.

  • Second‑degree and superficial third‑degree burns: helps prevent infection and promotes healing of the damaged skin.
  • Traumatic skin wounds: provides antimicrobial protection while supporting tissue regeneration.
  • Prevention and treatment of bacterial infection in burns: reduces microbial colonisation and facilitates recovery.

How It Works

  • Silver sulfadiazine releases silver ions that bind bacterial DNA and proteins, delivering broad‑spectrum antimicrobial activity, while sulfadiazine inhibits bacterial folic‑acid synthesis. Sodium hyaluronate creates a hydrated extracellular matrix that supports cell migration and wound closure, together accelerating healing of burn and traumatic skin injuries.

Side Effects

Ialugen Plus may cause local and systemic adverse reactions.

Common Side Effects

  • Local pain or burning sensation at the application site
  • Redness or erythema
  • Itching or mild pruritus
  • Mild edema or swelling
  • Increased wound exudate
  • Transient discoloration of surrounding skin

Serious or Rare Side Effects

  • Allergic contact dermatitis
  • Systemic silver toxicity (argyria) with prolonged use
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome
  • Necrotizing fasciitis (rare)
  • Anaphylaxis
  • Persistent ulceration or delayed wound healing

Precautions & Warnings

Before using Ialugen Plus, consider the following precautions:

  • Allergy assessment: verify no known sulfonamide or silver allergy.
  • Wound monitoring: observe for signs of worsening infection or delayed healing.
  • Contraindicated sites: avoid use on deep puncture wounds, compromised circulation, or mucous membranes.
  • Pediatric caution: use with care in neonates and infants, monitoring for systemic absorption.
  • Storage: Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ialugen Plus may interact with other medications or topical agents.

Major Interactions (Avoid)

  • Concurrent systemic sulfonamides (e.g., trimethoprim‑sulfamethoxazole) may increase toxicity.
  • Use with other silver‑containing dressings can lead to excess silver exposure.
  • Application with mercury‑based topical agents may cause adverse reactions.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids may reduce antimicrobial efficacy.
  • Anticoagulants (e.g., warfarin) could affect wound healing dynamics.
  • NSAIDs may mask pain, obscuring assessment of wound status.

Frequently Asked Questions

Ialugen Plus is a topical formulation containing silver sulfadiazine and sodium hyaluronate. It is indicated for the management of second‑degree and superficial third‑degree burns, as well as other traumatic skin wounds, where it helps prevent bacterial infection and supports the natural healing process.

Silver sulfadiazine releases silver ions that bind to bacterial DNA and proteins, disrupting essential cellular functions and providing broad‑spectrum antimicrobial activity. In addition, sulfadiazine interferes with bacterial folic‑acid synthesis, further inhibiting microbial growth.

The dosage of Ialugen Plus is determined by the prescribing clinician based on the size and depth of the burn or wound. Typically, a thin layer is applied once or twice daily after proper wound cleaning, but exact frequency and amount should follow the healthcare professional’s instructions.

Safety data for Ialugen Plus in pregnancy and lactation are limited. Because systemic absorption of silver and sulfadiazine can occur, it should be used only if the potential benefit justifies any possible risk to the fetus or infant, and only under medical supervision.

To order Ialugen Plus, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with standard silver sulfadiazine creams, Ialugen Plus adds sodium hyaluronate, which creates a hydrated matrix that can enhance wound healing and reduce scar formation. Unlike some antibiotic ointments, it offers broad antimicrobial coverage without relying on a single class of antibiotics, potentially lowering resistance risk.

Ialugen Plus should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from direct sunlight, and avoid exposure to moisture to maintain product stability.

After cleaning the burn or wound with sterile saline, apply a thin, even layer of Ialugen Plus to the affected area using sterile gloves or a gauze pad. Cover with a non‑adherent dressing if required, and re‑apply according to the clinician’s schedule, usually once or twice daily.

Serious risks include allergic contact dermatitis, systemic silver toxicity (argyria) with prolonged use, and rare severe hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of rash, swelling, or systemic symptoms, and the product should be discontinued if such reactions occur.

Ialugen Plus is contraindicated in individuals with known hypersensitivity to silver, sulfadiazine, or any sulfonamide. It should also be avoided on deep puncture wounds, compromised circulation areas, mucous membranes, and in patients with severe renal impairment without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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