Iasan (Aceclofenac)

Aceclofenac is indicated for inflammatory and degenerative joint disorders where cyclo‑oxygenase inhibition reduces pain and swelling.

• Osteoarthritis: reduces joint pain and improves functional mobility.
• Rheumatoid arthritis: alleviates inflammatory pain and stiffness in affected joints.
• Ankylosing spondylitis: diminishes spinal inflammation and associated discomfort.
• Musculoskeletal pain: provides relief from acute or chronic soft‑tissue pain.

• Aceclofenac exerts its anti‑inflammatory and analgesic effects by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition curtails the conversion of arachidonic acid to prostaglandins, thereby decreasing prostaglandin‑mediated inflammation, pain, and fever. By limiting prostaglandin synthesis at sites of injury, the drug reduces vascular permeability and leukocyte infiltration, contributing to its overall anti‑inflammatory profile.

Adverse reactions to aceclofenac may range from mild, frequently observed events to rare but serious conditions.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache or dizziness.
• Skin rash or itching.

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe liver injury or jaundice.
• Renal impairment or acute kidney injury.

When prescribing aceclofenac, clinicians should consider several precautionary measures to minimize risk.

• Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use.
• Monitor hepatic function: perform baseline liver tests and repeat as needed.
• Evaluate renal status: avoid in patients with severe kidney disease.
• Use caution in cardiovascular disease: consider alternative therapy if high risk.
• Avoid in known hypersensitivity to aceclofenac or other NSAIDs.
• Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Aceclofenac can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• High‑dose aspirin: additive antiplatelet effect.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal function.
• Diuretics: risk of electrolyte imbalance and renal impairment.
• Lithium: NSAIDs can increase lithium serum levels.