Product image of Iasocholine (Fluorocholine (18f) Chloride) supplied by GNH India

Iasocholine

Active Ingredient:
Fluorocholine (18f) Chloride
Origin:
EU

Iasocholine (Fluorocholine (18f) Chloride)

Fluorocholine (18F) Chloride, the active ingredient in Iasocholine, is a radiopharmaceutical presented as a sterile solution for injection for intravenous use. It is employed to visualize tissues with increased phospholipid synthesis, primarily in patients undergoing PET imaging for prostate cancer and other malignancies that exhibit high choline metabolism.

GNH India supplies Iasocholine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, diagnostic imaging facilities and research institutions worldwide, with adherence to EU quality standards. The product complies with European Union regulatory requirements for radiopharmaceuticals.

Manufacturer / TM Owner

Curium Austria Gmbh

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Indications & Clinical Uses

Iasocholine is used in PET imaging to assess cancers that demonstrate elevated choline metabolism.

  • Prostate cancer: enables PET imaging to detect, localize and stage disease, improving treatment planning.
  • High‑grade glioma: facilitates visualization of proliferating tumor tissue for diagnostic and therapeutic monitoring.
  • Other malignant lesions with high choline uptake: assists in locating and characterizing tumors such as head‑and‑neck or lung cancers where choline metabolism is increased.

How It Works

  • Fluorocholine (18F) chloride is a choline analogue that enters cells via choline transporters and is phosphorylated by choline kinase. The phosphorylated compound is incorporated into phosphatidylcholine, a major membrane phospholipid, leading to accumulation in cells with up‑regulated phospholipid synthesis such as proliferating tumor cells. The 18F radionuclide emits positrons, which are detected by PET scanners to generate high‑resolution images of metabolic activity.

Side Effects

Adverse reactions to Iasocholine are generally related to the injection procedure and the radiopharmaceutical nature of the product.

Common Side Effects

  • Injection site discomfort: mild pain or irritation at the site of administration.
  • Nausea: transient feeling of sickness after injection.
  • Flushing: brief warmth or redness of the skin.
  • Headache: mild to moderate headache occurring shortly after dosing.
  • Dizziness: temporary light‑headedness.
  • Fatigue: short‑term tiredness post‑administration.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure that may cause fainting.
  • Cardiac arrhythmia: irregular heart rhythm potentially life‑threatening.
  • Radiation‑induced skin injury: localized tissue damage at high exposure sites.

Precautions & Warnings

Specific safety considerations should be observed when using Iasocholine.

  • Pregnancy: unknown risk; avoid unless diagnostic benefit outweighs potential harm.
  • Breastfeeding: unknown; consider discontinuing nursing during and after administration.
  • Renal impairment: assess renal function; altered clearance may affect tracer distribution.
  • Hepatic impairment: use with caution; monitor for possible accumulation.
  • Known hypersensitivity: contraindicated in patients with allergy to fluorocholine or any formulation component.
  • Store at 2–8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions may influence tracer uptake or patient safety.

Major Interactions (Avoid)

  • Concurrent administration of other PET tracers: may cause competitive uptake and interfere with image interpretation.
  • High‑dose corticosteroids: can suppress choline kinase activity, reducing tracer accumulation.
  • Certain chemotherapeutic agents: may alter membrane synthesis, diminishing tracer uptake.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may affect cardiovascular response to injection.
  • Diuretics: can modify renal excretion of the tracer.
  • Iodinated contrast agents: may affect PET quantification if performed shortly before or after tracer injection.

Frequently Asked Questions

Iasocholine contains fluorocholine (18F) chloride, a PET tracer used to image prostate cancer and other malignancies with high choline metabolism, helping clinicians locate, stage, and monitor disease.

Fluorocholine is a choline analogue that enters cells via choline transporters, is phosphorylated by choline kinase, and incorporated into phosphatidylcholine. The 18F isotope emits positrons, producing PET images that reflect cellular proliferation.

The administered activity is determined by the prescribing nuclear medicine physician or radiologist based on patient weight, scanner sensitivity, and regulatory guidelines. The dose is prepared in a radiopharmacy and administered intravenously under controlled conditions.

Safety data are limited; the product has an unknown pregnancy category. Because it involves ionizing radiation, it is generally avoided in pregnant or nursing patients unless the diagnostic benefit outweighs the risk and appropriate precautions are taken.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and necessary import documentation.

Compared with 18F‑FDG, fluorocholine targets choline metabolism rather than glucose, offering higher specificity for prostate cancer and certain other tumors. It may provide clearer delineation of lesions with low FDG uptake but shares similar logistical requirements for radiopharmacy preparation and handling.

Iasocholine must be stored refrigerated at 2–8 °C in its original shielded container, protected from light. It should not be frozen or shaken. Prior to use, the solution is drawn under aseptic conditions and administered promptly to maintain radiochemical purity.

The product is supplied as a sterile solution for injection and is administered intravenously, typically as a bolus injection followed by a short waiting period (usually 10–20 minutes) before PET imaging begins, allowing tissue uptake of the tracer.

Serious adverse events include hypersensitivity reactions such as anaphylaxis, severe hypotension, arrhythmias, and radiation‑related tissue injury. Immediate medical attention is required if signs of allergic reaction, cardiovascular instability, or unexpected radiation exposure occur.

Patients with known hypersensitivity to fluorocholine or any component of the formulation should avoid use. It is also contraindicated in pregnant or nursing women unless essential, and caution is advised in individuals with severe renal or hepatic impairment where tracer clearance may be altered.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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