Product image of Iasoflu (Sodium Fluoride (18f)) supplied by GNH India

Iasoflu

Active Ingredient:
Sodium Fluoride (18f)
Origin:
EU

Iasoflu (Sodium Fluoride (18f))

Sodium fluoride, the active ingredient in Iasoflu, is a fluoride compound presented as an intravenous solution for medical use. It is employed primarily in diagnostic imaging of the skeletal system and, where indicated, for systemic fluoride supplementation.

GNH India supplies Iasoflu as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Curium Austria Gmbh

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Indications & Clinical Uses

Iasoflu (sodium fluoride) is used in clinical settings that involve bone metabolism and fluoride deficiency.

  • Bone imaging (PET/CT scans): enhances detection of skeletal lesions by highlighting areas of increased bone turnover.
  • Severe fluoride deficiency (when oral route not feasible): provides systemic fluoride to support bone mineralization.
  • Investigation of hyperparathyroidism (off‑label): assists in assessing bone turnover.

How It Works

  • Sodium fluoride dissociates to release fluoride ions, which replace hydroxyl groups in hydroxyapatite crystals of bone, forming fluorapatite that is more resistant to resorption. In diagnostic applications, the fluoride ion is taken up by osteoblasts in proportion to bone formation activity, allowing imaging agents labeled with fluorine‑18 to visualize skeletal metabolism.

Side Effects

Intravenous administration of sodium fluoride may be associated with a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Injection site pain: local tenderness or erythema.
  • Fever: low‑grade temperature elevation.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm requiring monitoring.
  • Severe hypocalcemia: marked drop in serum calcium levels.
  • Anaphylaxis: rapid onset allergic reaction with respiratory compromise.

Precautions & Warnings

Prior to initiating Iasoflu therapy, clinicians should consider several safety measures.

  • Renal function: assess baseline renal function and monitor during therapy.
  • Calcium levels: monitor serum calcium as fluoride can affect calcium homeostasis.
  • Thyroid function: evaluate thyroid status because fluoride may interfere with hormone synthesis.
  • Pregnancy and lactation: use only if clearly needed and prescribed by a specialist.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Sodium fluoride may interact with other medicines; awareness of key interactions helps mitigate risk.

Major Interactions (Avoid)

  • Calcium supplements: may exacerbate hypercalcemia when combined with high fluoride doses.
  • Thyroid hormone therapy: fluoride can reduce efficacy of levothyroxine.
  • Nephrotoxic drugs (e.g., aminoglycosides): increase risk of renal toxicity.

Moderate Interactions (Monitor Closely)

  • Vitamin D analogues: may potentiate bone mineral changes.
  • Loop diuretics: can alter electrolyte balance and affect fluoride clearance.
  • Anticoagulants: monitor coagulation parameters as fluoride may interfere with lab assays.

Frequently Asked Questions

Iasoflu contains sodium fluoride and is administered intravenously for diagnostic bone imaging and, in selected cases, for systemic fluoride supplementation when oral administration is not possible.

Sodium fluoride releases fluoride ions that replace hydroxyl groups in bone hydroxyapatite, forming fluorapatite which is more resistant to resorption. In imaging, fluoride is taken up by active bone‑forming cells, allowing visualization of skeletal metabolism.

The dose of Iasoflu is determined by the prescribing clinician based on the specific indication, patient characteristics, and clinical protocol. No fixed regimen is provided here.

Use of Iasoflu in pregnancy or while breastfeeding should only occur if clearly needed and under specialist supervision, as safety data are limited and potential risks to the fetus or infant cannot be ruled out.

To order Iasoflu, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Iasoflu (sodium fluoride) is a non‑radioactive fluoride source, whereas many bone imaging agents use fluorine‑18 labeled compounds. Sodium fluoride offers a simpler formulation but may have different sensitivity and logistical requirements compared with radiopharmaceutical alternatives.

Iasoflu should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture and direct light to maintain stability.

Iasoflu is given by intravenous injection or infusion under the supervision of qualified healthcare professionals, following the dosing instructions provided by the prescriber.

Serious risks include cardiac arrhythmia, severe hypocalcemia, and anaphylactic reactions. Patients should be monitored closely for these events, especially if they have underlying cardiac, electrolyte or allergy concerns.

Iasoflu is contraindicated in individuals with known hypersensitivity to fluoride, severe renal impairment, uncontrolled electrolyte disorders, or in patients where the risk of serious adverse reactions outweighs potential benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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