Product image of Ib-U-Ron (Ibuprofen) supplied by GNH India

Ib-U-Ron

Active Ingredient:
Ibuprofen
Origin:
EU

Ib-U-Ron (Ibuprofen)

Ibuprofen, the active ingredient in Ib-U-Ron, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a suppository for rectal use. It provides analgesic, antipyretic and anti‑inflammatory effects for the relief of mild to moderate pain, fever and inflammation in appropriate patient groups. The formulation is intended for short‑term management of symptoms associated with conditions such as musculoskeletal pain, dental pain and postoperative discomfort.

GNH India supplies Ib-U-Ron as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sigmapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Ibuprofen acts systemically to reduce pain, fever and inflammation by inhibiting cyclooxygenase enzymes.

  • Pain: Provides relief of mild to moderate acute pain such as headache, dental or musculoskeletal pain.
  • Fever: Reduces elevated body temperature associated with febrile illnesses.
  • Inflammation: Decreases swelling and discomfort in inflammatory conditions like minor injuries or postoperative sites.

How It Works

  • Ibuprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which reduces the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish peripheral sensitisation of nociceptors, lower the hypothalamic set‑point for temperature, and limit the inflammatory cascade, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Local rectal irritation or burning
  • Mild rash or itching

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Acute renal impairment or failure
  • Elevated liver enzymes or hepatitis
  • Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome
  • Cardiovascular events including myocardial infarction or stroke
  • Blood dyscrasias such as thrombocytopenia or agranulocytosis

Precautions & Warnings

Before using Ib-U-Ron, consider the following safety measures.

  • Assess renal function: use cautiously in patients with impaired kidney function.
  • Evaluate gastrointestinal risk: avoid in those with active ulcers or recent GI bleeding.
  • Monitor cardiovascular status: use with caution in patients with heart disease or uncontrolled hypertension.
  • Avoid in late pregnancy: contraindicated in the third trimester due to fetal risks.
  • Use the lowest effective dose for the shortest duration: limit exposure to reduce adverse events.
  • Store at below 25°C: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Ib-U-Ron can interact with several medicines; awareness helps minimise risk.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, DOACs): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of ibuprofen.
  • Methotrexate: reduced excretion can lead to toxicity.

Frequently Asked Questions

Ib-U-Ron is a rectally administered ibuprofen suppository indicated for the short‑term relief of mild to moderate pain, reduction of fever, and mitigation of inflammation associated with conditions such as musculoskeletal discomfort, dental pain, and postoperative soreness.

Ibuprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which decreases the synthesis of prostaglandins. Lower prostaglandin levels reduce pain signalling, lower the hypothalamic temperature set‑point, and limit the inflammatory response, providing analgesic, antipyretic, and anti‑inflammatory effects.

The appropriate dose of Ib-U-Ron is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and treatment goals. Dosage may vary, and patients should follow the prescriber’s instructions without self‑adjusting the amount or frequency.

Ib-U-Ron should be avoided in the third trimester of pregnancy because ibuprofen may affect fetal cardiovascular development. Use during the first two trimesters or while breastfeeding should only be considered if the potential benefit outweighs the risk and after consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the Ib-U-Ron product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Ib-U-Ron delivers ibuprofen, a well‑studied NSAID with a balanced COX‑1/COX‑2 inhibition profile. Compared with selective COX‑2 inhibitors, ibuprofen has a slightly higher risk of gastrointestinal irritation but a lower cardiovascular risk. Its rectal formulation offers an alternative route for patients who cannot take oral medications.

Store Ib-U-Ron at temperatures below 25 °C (77 °F). Keep the suppositories in their original packaging, protect them from moisture, direct sunlight and excessive heat to maintain product stability and potency.

Ib-U‑Ron is inserted rectally. The patient should lie on their side with the lower leg drawn toward the abdomen, gently push the suppository into the rectum using a gloved finger, and remain in that position for a few minutes to ensure proper absorption.

Serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and cardiovascular events like myocardial infarction or stroke. Patients should seek immediate medical attention if they notice signs such as black stools, sudden loss of kidney function, rash with blistering, or chest pain.

Ib-U‑Ron should not be used by individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, patients with severe renal or hepatic impairment, and women in the third trimester of pregnancy. Consultation with a healthcare professional is essential for anyone with underlying health conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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