Product image of Ibico (Mebeverine Hydrochloride) supplied by GNH India

Ibico

Active Ingredient:
Mebeverine Hydrochloride
Origin:
EU

Ibico (Mebeverine Hydrochloride)

Mebeverine Hydrochloride, the active ingredient in Ibico, is an antispasmodic presented as an oral formulation for oral use. It helps improve bowel habit regularity and reduces abdominal discomfort by relieving gastrointestinal smooth‑muscle spasms associated with irritable bowel syndrome and other functional bowel disorders.

GNH India supplies Ibico as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides full regulatory documentation to support global distribution. Ibico is manufactured under EU Good Manufacturing Practice guidelines to ensure consistent purity and potency.

Manufacturer / TM Owner

Bristol Laboratories Limited

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Indications & Clinical Uses

Mebeverine Hydrochloride acts on gastrointestinal smooth muscle to alleviate spasm in several functional bowel conditions.

  • Irritable bowel syndrome: reduces abdominal pain, cramping and improves stool consistency.
  • Functional bowel disorders: eases irregular bowel movements and decreases discomfort.
  • Spastic colon: relaxes colonic muscle tone, helping to normalize transit.

How It Works

  • Mebeverine Hydrochloride exerts its antispasmodic effect by inhibiting calcium influx into gastrointestinal smooth‑muscle cells, which reduces muscle contractility without impairing normal peristalsis. The drug acts directly on the muscle membrane rather than on autonomic receptors, allowing selective relaxation of spastic segments while preserving overall motility. Its action is independent of cholinergic or serotonergic pathways.

Side Effects

Mebeverine Hydrochloride is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Nausea: mild stomach upset.
  • Dry mouth: reduced salivation.
  • Headache: transient head pain.
  • Dizziness: light‑headed sensation.
  • Abdominal discomfort: mild cramps.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching or swelling.
  • Angioedema: swelling of face, lips or throat.
  • Severe cardiac arrhythmia: irregular heartbeat (very rare).

Precautions & Warnings

When prescribing Mebeverine Hydrochloride, consider the following precautions to ensure safe use.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor hepatic function: use cautiously in liver disease.
  • Observe for allergic reactions: discontinue if rash or swelling occurs.
  • Avoid in known hypersensitivity: do not prescribe to patients with previous mebeverine allergy.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mebeverine Hydrochloride may interact with other medicines; awareness of these interactions helps prevent adverse effects.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors: may increase mebeverine plasma concentrations.
  • Concomitant antispasmodics: risk of additive gastrointestinal relaxation.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may enhance dry‑mouth effect.
  • Tricyclic antidepressants: increased anticholinergic burden.
  • Diuretics: monitor electrolyte balance when combined.

Frequently Asked Questions

Ibico contains Mebeverine Hydrochloride, an antispasmodic indicated for the symptomatic relief of irritable bowel syndrome and other functional bowel disorders. It helps reduce abdominal pain, cramping and irregular bowel movements by relaxing gastrointestinal smooth muscle.

Mebeverine Hydrochloride works by blocking calcium entry into smooth‑muscle cells of the gastrointestinal tract. This inhibition reduces muscle contractility, easing spasms while preserving normal peristalsis, and does not act through cholinergic or serotonergic receptors.

The prescribed dose of Ibico is determined by the treating physician based on the individual’s clinical condition, severity of symptoms and response to therapy. Specific dosing regimens are not provided here and should follow the prescriber’s instructions.

Safety of Mebeverine Hydrochloride in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Ibico, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with anticholinergic agents such as hyoscine, Mebeverine (Ibico) provides smooth‑muscle relaxation without significant anticholinergic side effects like dry mouth or blurred vision. Its calcium‑channel‑blocking action offers a more targeted spasm relief while preserving normal gut motility.

Ibico should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency throughout its shelf life.

Ibico is taken orally, usually with a glass of water. It may be taken with or without food, as directed by the prescribing clinician. Swallow the tablets whole; do not crush or chew unless specifically advised.

Serious but rare risks include allergic reactions such as rash, itching, swelling, or angioedema, and very uncommon cardiac arrhythmias. Patients should seek immediate medical attention if they experience any signs of severe hypersensitivity or irregular heartbeat.

Ibico should be avoided in individuals with known hypersensitivity to Mebeverine Hydrochloride or any of its excipients. Caution is also advised for patients with severe hepatic or renal impairment, and it should not be used without medical supervision in those populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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