Product image of Ibidreid (Colecalciferol) supplied by GNH India

Ibidreid

Active Ingredient:
Colecalciferol
Origin:
EU

Ibidreid (Colecalciferol)

Colecalciferol, the active ingredient in Ibidreid, is a vitamin D analog presented as an oral tablet for oral use. It is used to treat vitamin D deficiency and support bone health in children and adults.

GNH India supplies Ibidreid as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibi G. Lorenzini Spa

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Indications & Clinical Uses

Ibidreid (colecalciferol) is used to address conditions related to vitamin D deficiency and bone metabolism.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels.
  • Rickets: prevents bone softening and deformities in children.
  • Osteomalacia: improves bone mineralization in adults.
  • Bone health maintenance: supports calcium absorption for overall skeletal health.

How It Works

  • Colecalciferol is absorbed in the intestine and converted in the liver to 25‑hydroxyvitamin D, then to the active hormone calcitriol in the kidneys. Calcitriol binds to the nuclear vitamin D receptor (VDR) in target cells, stimulating transcription of calcium‑binding proteins and enhancing intestinal absorption of calcium and phosphate, which are essential for bone mineralization.

Side Effects

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels causing fatigue or nausea.
  • Nausea: mild stomach upset after oral intake.
  • Constipation: reduced bowel movements.
  • Headache: occasional mild headache.
  • Dry mouth: sensation of oral dryness.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Severe hypercalcemia: may lead to cardiac arrhythmia.
  • Hypercalciuria: excess calcium in urine, risk of kidney stones.
  • Renal stones: formation of calcium‑based stones in kidneys.
  • Allergic reactions: rash, itching, or swelling.
  • Hypervitaminosis D: toxicity from excessive vitamin D levels.
  • Acute pancreatitis: very rare inflammatory pancreas condition.

Precautions & Warnings

Before initiating therapy, consider patient-specific factors and monitor appropriately.

  • Baseline assessment: check serum calcium and 25‑hydroxyvitamin D levels.
  • Renal function: adjust use in patients with impaired kidney function.
  • Hypercalcemia: avoid in individuals with existing high calcium levels.
  • Sarcoidosis or granulomatous disease: use with caution due to altered vitamin D metabolism.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Colecalciferol may interact with several medicines that affect calcium balance.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcemia.
  • High-dose vitamin A supplements: synergistic hypercalcemia risk.
  • Calcium supplements: may cause excessive calcium accumulation.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): accelerate vitamin D metabolism, reducing efficacy.
  • Glucocorticoids: decrease calcium absorption, may require dose adjustment.
  • Orlistat: reduces intestinal absorption of fat‑soluble vitamins, including vitamin D.

Frequently Asked Questions

Ibidreid contains colecalciferol, a form of vitamin D3, and is indicated for the treatment of vitamin D deficiency, the prevention of rickets in children, and the maintenance of normal bone health in adults. It helps correct low serum vitamin D levels and supports calcium metabolism.

Colecalciferol is absorbed from the gut and converted in the liver to 25‑hydroxyvitamin D, then to the active hormone calcitriol in the kidneys. Calcitriol binds to the vitamin D receptor in intestinal cells, stimulating the production of calcium‑binding proteins that increase calcium and phosphate absorption, essential for bone mineralization.

The appropriate dose of Ibidreid is determined by the prescribing healthcare professional based on the patient’s age, baseline vitamin D status, and clinical needs. Dosage may be adjusted after laboratory monitoring of serum calcium and 25‑hydroxyvitamin D levels.

Safety data for colecalciferol in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit profile for each individual. Women who are pregnant or breastfeeding should discuss use with their physician before starting therapy.

To order Ibidreid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibidreid provides colecalciferol, the same active ingredient found in most vitamin D3 supplements. Differences among products are usually related to dosage strength, formulation (tablet, capsule, liquid) and regulatory status. Clinical efficacy is comparable when equivalent doses are administered.

Store Ibidreid at room temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging is tightly closed to maintain stability.

Ibidreid is taken orally. Swallow the tablet whole with a glass of water. It may be taken with or without food, although taking it with a meal that contains fat can improve absorption of the fat‑soluble vitamin.

The most serious risks include hypercalcemia, which can cause cardiac arrhythmias, renal stones, and, in rare cases, severe allergic reactions. Patients should be monitored for signs of elevated calcium levels, especially if they have underlying conditions that affect calcium metabolism.

Ibidreid should be avoided in individuals with known hypersensitivity to colecalciferol or any excipients, those with existing hypercalcemia, severe renal impairment, or diseases such as sarcoidosis that alter vitamin D metabolism. A healthcare professional should assess suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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