Product image of Ibolex (Dexibuprofen) supplied by GNH India

Ibolex

Active Ingredient:
Dexibuprofen
Origin:
EU

Ibolex (Dexibuprofen)

Dexibuprofen, the active ingredient in Ibolex, is a non‑steroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It provides analgesic and anti‑inflammatory effects for adults experiencing mild to moderate pain and inflammation.
GNH India supplies Ibolex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Czech S.R.O

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Indications & Clinical Uses

Dexibuprofen is used to manage conditions involving pain and inflammation within the musculoskeletal and dental pathways.

  • Acute musculoskeletal pain: reduces pain intensity and improves functional ability.
  • Inflammatory arthritis: diminishes joint swelling and stiffness.
  • Dental postoperative pain: alleviates discomfort after dental procedures.

How It Works

  • Dexibuprofen selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis lowers peripheral sensitisation of nociceptors, thereby providing analgesic, antipyretic, and anti‑inflammatory effects at sites of tissue injury.

Side Effects

Dexibuprofen may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dyspepsia: indigestion or heartburn.
  • Abdominal pain: discomfort in the stomach area.
  • Headache: transient head pain.
  • Dizziness: feeling light‑headed.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially life‑threatening.
  • Severe liver injury: jaundice or elevated enzymes.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Anaphylaxis: acute allergic response.
  • Renal impairment: reduced kidney function.
  • Cardiovascular events: increased risk of heart attack or stroke.

Precautions & Warnings

Before initiating therapy with Dexibuprofen, consider the following safety measures.

  • Assess gastrointestinal risk: avoid in patients with active ulcer disease or a history of GI bleeding.
  • Evaluate cardiovascular status: use cautiously in individuals with heart disease or hypertension.
  • Check renal function: adjust or monitor in patients with impaired kidney function.
  • Review concomitant anticoagulant use: increased bleeding risk when combined with warfarin or similar agents.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Dexibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Corticosteroids: increased ulcer risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: potential for renal impairment when combined.

Frequently Asked Questions

Ibolex contains dexibuprofen, an NSAID that is used to relieve mild to moderate pain, reduce inflammation, and lower fever. It is commonly prescribed for conditions such as musculoskeletal pain, inflammatory arthritis, and dental discomfort after procedures.

Dexibuprofen works by inhibiting the cyclooxygenase (COX) enzymes, which are essential for the production of prostaglandins. By reducing prostaglandin synthesis, it lessens inflammation, pain signals, and fever responses at the site of injury.

The appropriate dose of Ibolex is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of dexibuprofen in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Ibolex, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Dexibuprofen is the active S‑enantiomer of ibuprofen, offering similar analgesic and anti‑inflammatory potency with potentially improved gastrointestinal tolerability compared with the racemic mixture. Compared with other NSAIDs, its safety profile is comparable, but individual response and risk factors may differ.

Ibolex should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Ibolex is taken orally with a full glass of water. It can be taken with or without food, although taking it with food may reduce the chance of stomach upset. Swallow the tablet whole; do not crush or chew unless directed by a healthcare professional.

The most serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, renal impairment, and increased cardiovascular events in susceptible individuals. Patients should seek immediate medical attention if they notice signs of serious bleeding, rash, or breathing difficulties.

Ibolex should be avoided in individuals with known hypersensitivity to dexibuprofen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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