Product image of Ibrigan (Timolol Maleate, Bimatoprost) supplied by GNH India

Ibrigan

Active Ingredient:
Timolol Maleate, Bimatoprost
Origin:
EU

Ibrigan (Timolol Maleate, Bimatoprost)

Timolol maleate and bimatoprost, the active ingredients in Ibrigan, are a beta‑blocker and prostaglandin analog presented as an ophthalmic solution for ocular (topical) use. They lower intra‑ocular pressure in patients with primary open‑angle glaucoma or ocular hypertension.

GNH India supplies Ibrigan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Davi Ii - Farmacêutica, S.A.

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Indications & Clinical Uses

Ibrigan is used to manage conditions that involve elevated intra‑ocular pressure within the glaucoma disease family.

  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow optic nerve damage.
  • Ocular hypertension: lowers pressure to prevent progression to glaucoma.
  • Patients at risk of optic‑nerve damage: helps preserve visual field by maintaining normal pressure levels.

How It Works

  • Timolol maleate decreases aqueous humor production by non‑selectively blocking β‑adrenergic receptors in the ciliary body, while bimatoprost mimics prostaglandin F2α to increase uveoscleral outflow of aqueous humor. The combined actions result in a net reduction of intra‑ocular pressure.

Side Effects

Ibrigan may cause ocular and systemic reactions, most of which are mild and transient.

Common Side Effects

  • Eye irritation or burning sensation.
  • Redness of the eye.
  • Blurred vision.
  • Dry eyes.
  • Eyelash growth.
  • Mild headache.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., swelling, rash, difficulty breathing).
  • Significant decrease in heart rate or blood pressure.
  • Worsening of asthma or chronic obstructive pulmonary disease.
  • Persistent eye pain or vision loss.
  • Periorbital skin darkening.
  • Corneal edema.

Precautions & Warnings

Before using Ibrigan, consider the following precautions.

  • Cardiovascular disease: monitor heart rate and blood pressure.
  • Respiratory conditions: avoid use in patients with asthma or COPD.
  • Pregnancy and lactation: discuss risks with a healthcare professional.
  • Concomitant eye medications: separate instillation times to prevent interaction.
  • Contact lens wearers: remove lenses before and wait at least 15 minutes after application.
  • Store at below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Ibrigan can interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers (systemic): may cause additive cardiovascular depression.
  • Sympathomimetic agents (e.g., epinephrine eye drops): can reduce Ibrigan's efficacy.

Moderate Interactions (Monitor Closely)

  • Carbonic anhydrase inhibitors: may enhance intra‑ocular pressure lowering effect.
  • Anticholinergic eye drops: could affect tear film stability.
  • Systemic antihypertensives: monitor for excessive blood pressure reduction.

Frequently Asked Questions

Ibrigan is an ophthalmic solution indicated for lowering intra‑ocular pressure in adults with primary open‑angle glaucoma or ocular hypertension, helping to prevent optic‑nerve damage and preserve vision.

Timolol maleate blocks β‑adrenergic receptors in the eye’s ciliary body, reducing the production of aqueous humor, which contributes to a decrease in intra‑ocular pressure.

The dosing regimen for Ibrigan is determined by the prescribing clinician based on the patient’s condition and response; typical practice involves one drop in the affected eye(s) once daily.

Safety of Ibrigan in pregnancy or lactation has not been established. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks with their healthcare provider before use.

To order Ibrigan, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Ibrigan combines a beta‑blocker (timolol) and a prostaglandin analog (bimatoprost) in a single formulation, offering dual mechanisms of pressure reduction. This can provide comparable or greater efficacy than single‑agent drops while simplifying the treatment regimen.

Ibrigan should be stored at temperatures below 25 °C, in its original container, protected from light and moisture. Do not freeze the solution.

Ibrigan is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, place one drop into the conjunctival sac, and close the eye gently for a few minutes.

Serious risks include severe allergic reactions, significant drops in heart rate or blood pressure, worsening of asthma or COPD, and rare cases of corneal edema or vision loss. Immediate medical attention is required if these occur.

Ibrigan is contraindicated in patients with known hypersensitivity to timolol, bimatoprost, or any component of the formulation, as well as those with severe sinus bradycardia, uncontrolled asthma, or acute pulmonary conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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