Ibu 400 - 1 A Pharma (Ibuprofen)

Ibuprofen acts by inhibiting cyclooxygenase enzymes, reducing prostaglandin‑mediated inflammation and pain.

• Mild to moderate pain: Provides analgesic relief for conditions such as backache, menstrual cramps, or minor injuries.
• Fever: Reduces elevated body temperature associated with infectious or inflammatory processes.
• Headache: Alleviates tension‑type and mild migraine‑related headaches.
• Dental pain: Controls postoperative or dental procedural discomfort.
• Musculoskeletal pain: Decreases inflammation and soreness in joints, muscles and soft tissues.

• Ibuprofen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers fever set‑points in the hypothalamus, and curtails inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
• Heartburn or acid reflux.
• Dizziness or mild vertigo.
• Headache.
• Skin rash or mild itching.
• Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Severe renal impairment or acute kidney injury.
• Anaphylactic or severe allergic reactions.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Hepatotoxicity with marked liver enzyme elevation.
• Hematologic abnormalities such as thrombocytopenia.

Before using ibuprofen, consider the following precautions:

• Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
• Review renal function: avoid in patients with severe kidney disease.
• Monitor cardiovascular status: use cautiously in patients with hypertension or heart disease.
• Check for drug allergies: avoid if known hypersensitivity to ibuprofen or other NSAIDs.
• Avoid use in late pregnancy unless directed by a physician.
• Store at room temperature: keep in the original pack, protect from moisture and heat.

Ibuprofen can interact with several medicines. Review the following categories:

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
• Corticosteroids: synergistic ulcerogenic effect.
• Lithium: elevated lithium serum levels.
• Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: may impair renal perfusion.
• Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.
• Antihypertensives: potential attenuation of blood‑pressure‑lowering effect.
• Alcohol: additive gastrointestinal irritation.