Product image of Ibu-Lysin (Ibuprofen D,l-Lysinate) supplied by GNH India

Ibu-Lysin

Active Ingredient:
Ibuprofen D,l-Lysinate
Origin:
EU

Ibu-Lysin (Ibuprofen D,l-Lysinate)

Ibuprofen D,l-Lysinate, the active ingredient in Ibu-Lysin, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects for mild to moderate pain in adults.

GNH India supplies Ibu-Lysin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Ibu-Lysin (ibuprofen D,l‑lysinate) is used to manage conditions involving pain, fever and inflammation.

  • Mild to moderate pain: reduces pain perception and improves functional ability.
  • Fever: lowers elevated body temperature through prostaglandin inhibition.
  • Arthritis: alleviates inflammatory joint pain and swelling.

How It Works

  • Ibuprofen D,l‑lysinate exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition decreases the synthesis of prostaglandins, which are mediators of pain, fever, and inflammation, thereby providing analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Skin rash: mild erythematous eruption.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment, especially in volume‑depleted patients.
  • Severe allergic reactions such as anaphylaxis or angioedema.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, consider patient‑specific risk factors and monitor appropriately.

  • Gastro‑intestinal risk: assess history of ulcers or bleeding and use gastro‑protective agents if needed.
  • Renal function: monitor serum creatinine in patients with pre‑existing kidney disease.
  • Pregnancy: avoid use in the third trimester due to fetal cardiovascular risks.
  • Concomitant anticoagulants: increase bleeding risk; use caution.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibu-Lysin may interact with several drug classes; clinical judgment is required.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: increased risk of ulceration.
  • ACE inhibitors or ARBs: potential for reduced renal perfusion.
  • Lithium: elevated lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate renal impairment.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ibu-Lysin contains ibuprofen D,l‑lysinate, an NSAID that is used to relieve mild to moderate pain, reduce fever, and treat inflammatory conditions such as arthritis. It works by decreasing the production of prostaglandins, which are chemicals that cause pain, fever, and swelling.

Ibuprofen D,l‑lysinate non‑selectively blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This inhibition reduces the synthesis of prostaglandins, the mediators responsible for pain, fever, and inflammation, thereby providing analgesic, antipyretic, and anti‑inflammatory effects.

The appropriate dose of Ibu-Lysin is determined by the prescribing healthcare professional based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ibu-Lysin is classified as pregnancy category B, indicating no proven risk in animal studies, but it should be used only if clearly needed. It is generally avoided in the third trimester. Breastfeeding mothers should consult their physician, as ibuprofen can be excreted in breast milk.

To order Ibu-Lysin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Ibu-Lysin uses the lysine salt form of ibuprofen, which can improve solubility and may lead to faster absorption compared with standard ibuprofen tablets. Therapeutic effects are similar, but the lysinate formulation may offer a slightly different onset of action or tolerability profile.

Ibu-Lysin should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ibu-Lysin is taken orally, usually with a glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s directions.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, acute kidney injury, and rare but severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of these conditions.

Ibu-Lysin should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, or severe renal impairment. It is also contraindicated in the third trimester of pregnancy and in patients taking certain anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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