Product image of Ibubel (Ibuprofen) supplied by GNH India

Ibubel

Active Ingredient:
Ibuprofen
Origin:
EU

Ibubel (Ibuprofen)

Ibuprofen, the active ingredient in Ibubel, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a rectal suppository for local administration. It provides analgesic, antipyretic and anti‑inflammatory effects, making it suitable for relieving pain, reducing fever and managing inflammation in adults and children when oral routes are unsuitable or contraindicated.

GNH India supplies Ibubel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution channels that meet EU regulatory standards and a reliable logistics network for rectal dosage forms.

Manufacturer / TM Owner

Belupo D.O.O.

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Indications & Clinical Uses

Ibuprofen suppositories are used to manage pain, fever and inflammatory conditions that benefit from systemic COX inhibition.

  • Mild to moderate pain: provides relief from headache, dental pain and postoperative discomfort.
  • Fever: reduces elevated body temperature in adults and children.
  • Inflammatory conditions: alleviates symptoms of musculoskeletal inflammation such as sprains or arthritis flares.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces peripheral sensitisation, lowers the hypothalamic set‑point for temperature, and diminishes inflammatory exudate formation, thereby providing analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Common Side Effects

  • Abdominal discomfort or dyspepsia.
  • Nausea or mild vomiting.
  • Headache or dizziness.
  • Local rectal irritation.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment or failure.
  • Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome.
  • Hepatic dysfunction or elevated liver enzymes.

Precautions & Warnings

Before using Ibubel, consider the following precautions:

  • Assess renal function: avoid in patients with severe renal impairment.
  • Monitor gastrointestinal risk: use with caution in individuals with a history of ulcers or bleeding.
  • Avoid concurrent anticoagulants: increased risk of bleeding.
  • Limit use in pregnancy: consult a healthcare professional before use.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibubel may interact with several medicines. Review the following:

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • High‑dose aspirin: additive gastrointestinal toxicity.
  • Lithium: ibuprofen can raise serum lithium concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • SSRIs (e.g., sertraline): increased potential for bleeding.

Frequently Asked Questions

Ibubel is a rectal suppository containing ibuprofen, an NSAID that provides analgesic, antipyretic and anti‑inflammatory effects. It is indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as musculoskeletal aches when oral administration is not appropriate.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the synthesis of prostaglandins, which are mediators of pain, fever, and inflammation, thereby reducing these symptoms throughout the body.

The appropriate dose of Ibubel is determined by a qualified prescriber based on the patient’s age, weight, clinical condition and response to therapy. Healthcare professionals follow local guidelines and product labeling to select the correct strength and frequency for each individual.

Ibuprofen should be used with caution during pregnancy, especially in the third trimester, because it may affect fetal cardiovascular development. While limited data exist for breastfeeding, ibuprofen does pass into breast milk in small amounts. Consultation with a healthcare provider is essential before use.

To place an order, submit an enquiry on the Ibubel product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibubel delivers ibuprofen systemically via the rectal route, offering an alternative when oral intake is impossible or poorly tolerated. Compared with oral ibuprofen, the suppository may provide faster absorption and fewer gastrointestinal side effects, but the overall efficacy and safety profile remain consistent with other ibuprofen products.

Store Ibubel at room temperature, ideally below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity, which could affect its stability.

Ibubel is inserted rectally, typically with gloved fingers, after the patient has emptied the bowels if possible. The suppository should be placed gently into the rectum, lying on the side, and left in place to dissolve completely for optimal absorption.

Serious risks include gastrointestinal bleeding or ulcer perforation, acute kidney injury, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and liver toxicity. Patients should seek immediate medical attention if they experience signs of bleeding, sudden kidney problems, or severe skin reactions.

Ibubel should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, severe renal or hepatic impairment, and in late‑stage pregnancy without medical advice. Consultation with a healthcare professional is required for all contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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